| Project/Area Number |
20590679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
|
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| Research Institution | Niigata University (2009-2011)
Shimane University (2008) |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHITA Haruo 島根大学, 医学部, 教授 (90292599)
FUJIHARA Junko 島根大学, 医学部, 助教 (20346381)
|
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| Co-Investigator(Renkei-kenkyūsha) |
YASUDA Toshihiro 福井大学, 医学部, 教授 (80175645)
|
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| Project Period (FY) |
2008 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心筋梗塞 / DNase I / 司法解剖 / 法医学 / DNaseI / NT-proBNP / DNaseI活性 / BNP / DNase活性 / 遺伝的多型 / 急性心筋梗塞 / 法医病理学 / 病理組織学的診断 / 生化学 |
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| Research Abstract |
The aim of this study was confirm a molecular basis for utilization of Dnase I as a diagnostic marker death due to acute myocardial infarction; (1) SNP of Dnase I exon8, A2317G is the same tendency of Asians, and this SNP affect to heat sensitivity and optimum pH. (2) Detect of Dnase I activity within 10 minutes using microchip electrophoresis. (3) Unable to detect cytokines mRNA of postmortem cardiac tissue. (4) Unable to detect NT-pro-BNP using postmortem blood for novel diagnostic method. (5) SNP of Dnase I, type of 1-2 is the risk factor for myocardial infarction.
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