A novel method of diagnosis for acute myocardial infarction
| Project/Area Number |
20590679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Niigata University (2009-2011)
Shimane University (2008) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHITA Haruo 島根大学, 医学部, 教授 (90292599)
FUJIHARA Junko 島根大学, 医学部, 助教 (20346381)
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| Co-Investigator(Renkei-kenkyūsha) |
YASUDA Toshihiro 福井大学, 医学部, 教授 (80175645)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心筋梗塞 / DNase I / 司法解剖 / 法医学 / DNaseI / NT-proBNP / DNaseI活性 / BNP / DNase活性 / 遺伝的多型 / 急性心筋梗塞 / 法医病理学 / 病理組織学的診断 / 生化学 |
|---|
| Research Abstract |
The aim of this study was confirm a molecular basis for utilization of Dnase I as a diagnostic marker death due to acute myocardial infarction; (1) SNP of Dnase I exon8, A2317G is the same tendency of Asians, and this SNP affect to heat sensitivity and optimum pH. (2) Detect of Dnase I activity within 10 minutes using microchip electrophoresis. (3) Unable to detect cytokines mRNA of postmortem cardiac tissue. (4) Unable to detect NT-pro-BNP using postmortem blood for novel diagnostic method. (5) SNP of Dnase I, type of 1-2 is the risk factor for myocardial infarction.
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Report
(6 results)
Research Products
(24 results)
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[Journal Article] Functional and genetic survey of all known the SNPs within human deoxyribonuclease I gene in wide-ranging ethnic groups2011
Author(s)
Fujihara J, Ueki M, Yasuda T, Iida R, Soejima M, Koda Y, Kimura-Kataoka K,Kato H, Panduro A, Tongu M, Takeshita H
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Journal Title
DNA and Cell Biol.
Volume: 30(4)
Issue: 4
Pages: 205-217
DOI
Related Report
Peer Reviewed
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[Journal Article] A biochemical and genetic study on all non-synonymous single nucleotide polymorphisms of the gene encoding human deoxyribonuclease I potentially relevant to autoimmunity2010
Author(s)
Yasuda T, Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Tsubota E, Soejima M, Koda Y, Kato H, Panduro A
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Journal Title
Int J Biochem Cell Biol.
Volume: 42(7)
Issue: 7
Pages: 1216-1225
DOI
Related Report
Peer Reviewed
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[Book] NA多型vol.162009
Author(s)
藤原純子, 竹下治男, 高塚尚和, 安田年博, 植木美鈴, 飯田礼子, 河合康幸, 中島たみ子, 小湊慶彦, 副島美貴子, 神田芳郎
Publisher
東洋書店
Related Report
