Morphological and immunohistochemical study on vascular and lymphatic angiogenesis in rat wound.

• Project/Area Number: 20590686
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Teikyo University
• Principal Investigator: NOGAMI Makoto Teikyo University, 医学部, 教授 (20218291)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Ichiroh 帝京大学, 医学部, 講師 (40091045)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 法医病理学 / VEGF / リンパ管 / ポドプラニン / 血管新生 / 創

Research Abstract

In this research, we clarified the morphological difference in the healing process between the vascular and lymphatic vessels. We also showed the important role of leucocytes in the early stage production of VEGF in the skin wound. As a novel observation, we identified mitotic vascular endothelial cells in the electron microscopy and in immunohistochemistry.

Research Products

• [Journal Article] Vascular endothelial growth factor in the early stage of skin incision wounds in cyclophosphamide-induced leukocytopenic rats (2010)
  • Author(s): Makoto Nogami, Tomoaki Hoshi, Yoko Toukairin, Tomomi Arai
  • Journal Title: Legal Medicine 12 Pages: 128-131
  • NAID: 10027575825
  • Peer Reviewed
• [Journal Article] Vascular endothelial growth factor in the early stage of skin incision wounds in cyclophosphamide-induced leukocytopenic rats. (2010)
  • Author(s): Makoto Nogami, Tomoaki Hoshi, Yoko Toukairin, Tomomi Arai
  • Journal Title: Legal Medicine Volume: 12 Pages: 128-131
  • NAID: 10027575825
  • Peer Reviewed
• [Journal Article] Morphology of lymphatic regeneration in rat incision wound healing in comparison with vascular regeneration (2009)
  • Author(s): Makoto Nogami, Tomoaki Hoshi, Tomomi Arai, Yoko Toukairin, Michiho Takama, Ichiro Takahashi
  • Journal Title: Legal Medicine 11 Pages: 213-218
  • Peer Reviewed
• [Journal Article] Morphology of lymphatic regeneration in rat incision wound healing in comparison with vascular regeneration. (2009)
  • Author(s): Makoto Nogami, Tomoaki Hoshi, Yoko Toukairin, Michiho Takama, Ichiro Takahashi.
  • Journal Title: Legal Medicine 11 Pages: 213-218
  • Peer Reviewed
• [Presentation] 創傷治癒過程における血管新生の微細形態学的検討 (2009)
  • Author(s): 高橋一郎、高間みちほ、星智昭、東海林洋子、新井智美、野上誠
  • Organizer: 日本顕微鏡学会第65回学術講演会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-27
• [Presentation] ラット皮膚創におけるVEGF産生に対するシクロフォスファミドの影響 (2009)
  • Author(s): 星智昭、新井智美、東海林洋子、野上誠
  • Organizer: 第93次日本法医学会学術全国集会(抄録:日本法医学雑誌64(1)、89頁、2009)
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-15
• [Presentation] ラット皮膚創におけるVEGF産生に対するシクロフォスファミドの影響 (2009)
  • Author(s): 野上誠
  • Organizer: 日本法医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-04-24
• [Presentation] 創傷治癒過程における血管新生の微細形態学的検討. (2009)
  • Author(s): 高橋一郎
  • Organizer: 日本顕微鏡学会第65回学術講演会
  • Place of Presentation: 仙台
• [Presentation] ラット皮膚創におけるリンパ管修復過程の検討 (2008)
  • Author(s): 野上 誠
  • Organizer: 日本法医学会総会
  • Place of Presentation: 長崎市
  • Year and Date: 2008-04-24