| Project/Area Number |
20590692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
TANAKA Noriyuki University of Occupational and Environmental Health, Japan, 医学部, 教授 (60126597)
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| Co-Investigator(Kenkyū-buntansha) |
KITA Toshiro 産業医科大学, 医学部, 准教授 (00131912)
TANAKA Toshiko 産業医科大学, 医学部, 講師 (80141745)
SATO Hiroaki 産業医科大学, 医学部, 講師 (50441845)
KASAI Kentaro 産業医科大学, 医学部, 助教 (40169397)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 社会医学 / 法医学 / ショック / サイトカイン / 出血性ショック / BUN / クレアチニン |
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| Research Abstract |
The role of neutrophils was studied by quantitatively grading four groups of hemorrhaging rats, focused on the kidney, so-called shock organ. As the amount of bleeding increased, the initial activation of p38 mitogen activated protein kinase(MAPK) and the expression of proinflammatory cytokines, such as tumor necrosis factor(TNF)-α and interleukin(IL)-1β, were progressively enhanced. The severity of renal dysfunction, manifested by serum creatinine concentration, was well correlated with the degree of neutrophils accumulation in the kidney. The present results confirmed that the frequency of activated neutrophils recruited into the kidney might be a useful for morphological diagnosis on the severity of renal dysfunction and that the increase of initial p38 MAPK activation following hemorrhagic shock quantitatively enhanced the ensuing inflammatory renal dysfunction in response to the degree and the progression of hemorrhagic shock.
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