Role of Food Intolerance and Protease on Pathophysiology of Irritable Bowel Syndrome
Project/Area Number |
20590693
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | Tohoku University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
FUKUDO Shin 東北大学, 大学院・医学系研究科, 教授 (80199249)
WATANABE Satoshi 東北大学, 大学院・医学系研究科, 非常勤講師 (40431506)
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Co-Investigator(Renkei-kenkyūsha) |
KANO Michiko 東北大学, 大学院・医学系研究科, 助教 (20344658)
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Project Period (FY) |
2008 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 過敏性腸症候群 / 炎症免疫 / 内臓知覚 / 大腸運動 / メシル酸カモスタット / プラセボ / 食物不耐症 / 消化管生理 / 過敏性症候群 / 食物不耐性 / 腹部膨満感 / QOL / 無作為比較化試験 / 直腸知覚 / 直腸平滑筋トーン |
Research Abstract |
Our aims were to determine whether camostat mesilate (600mg/day), a synthetic protease inhibitor, changes visceral pain sensitivity and gastrointestinal motility and whether these changes affect clinical symptom severity in patients with irritable bowel syndrome (IBS). As a result, camostat mesilate has no effect on visceral sensitivity, colonic motility or serum cytokines compared with placebo in IBS patients.
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Report
(6 results)
Research Products
(237 results)
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[Journal Article] Lifestyle and psychological factors related to irritable bowel syndrome in nursing and medical school students2011
Author(s)
Okami Y, Kato T, Nin G, Harada K, Aoi W, Wada S, Higashi A, Okuyama S, Ichikawa H, Kanazawa M, Fukudo S.
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Journal Title
J Gastrointestinal
Volume: 46
Issue: 12
Pages: 1403-1410
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention2009
Author(s)
Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, Aoki M.
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Journal Title
Neuroimage
Volume: 47
Issue: 3
Pages: 946-51
DOI
Related Report
Peer Reviewed
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[Journal Article] Brain activation covari ated with changes in heart rate, heart rate variability and plasma catecholamines during rectal distention2009
Author(s)
Suzuki H, Watanabe S, Hamaguchi T, Mine H, Terui T, Kanazawa M, Oohisa N, Maruyama M, Yambe T, Itoh M, Fukudo S.
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Journal Title
Psychosom Med
Volume: 71
Issue: 6
Pages: 619-626
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of serotonintransporter gene polymorphism on brainactivation by colorectal distention.2009
Author(s)
Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, Aoki M.
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Journal Title
Neuroimage 47
Pages: 946-951
Related Report
Peer Reviewed
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[Journal Article] Brain activationc ovariated with changes in heart rate, heart rate variability and plasma catecholamines during rectal distention.2009
Author(s)
Suzuki H, Watanabe S, Hamaguchi T, Mine H, Terui T, Kanazawa M, Oohisa N, Maruyama M, Yambe T, Itoh M, Fukudo S.
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Journal Title
Psychosom Med 71
Pages: 619-626
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
金澤素, et al.
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Journal Title
Irritable Bowel Syndrome(Nova Science Publishers)
Pages: 1-8
Related Report
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[Journal Article]2009
Author(s)
金澤素, 他
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Journal Title
別冊日本臨床 消化管症候群(第2版)-その他の消化管疾患を含めて-(日本臨床社)
Pages: 214-219
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[Presentation] Increased stomach aches in children are associated with parent IBS status and maladaptive parenting in Japan2011
Author(s)
Kanazawa M, Whitehead WE, Levy, RL Seino S, Tatsuta N, Palsson OS, Turner MJ, Endo Y, Nakai K, Satoh H, Fukudo S.
Organizer
The 112th Annual Meeting of American Gastroenterological Association
Place of Presentation
Chicago, USA
Year and Date
2011-05-08
Related Report
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