| Project/Area Number |
20590693
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDO Shin 東北大学, 大学院・医学系研究科, 教授 (80199249)
WATANABE Satoshi 東北大学, 大学院・医学系研究科, 非常勤講師 (40431506)
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| Co-Investigator(Renkei-kenkyūsha) |
KANO Michiko 東北大学, 大学院・医学系研究科, 助教 (20344658)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 過敏性腸症候群 / 炎症免疫 / 内臓知覚 / 大腸運動 / メシル酸カモスタット / プラセボ / 食物不耐症 / 消化管生理 / 過敏性症候群 / 食物不耐性 / 腹部膨満感 / QOL / 無作為比較化試験 / 直腸知覚 / 直腸平滑筋トーン |
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| Research Abstract |
Our aims were to determine whether camostat mesilate (600mg/day), a synthetic protease inhibitor, changes visceral pain sensitivity and gastrointestinal motility and whether these changes affect clinical symptom severity in patients with irritable bowel syndrome (IBS). As a result, camostat mesilate has no effect on visceral sensitivity, colonic motility or serum cytokines compared with placebo in IBS patients.
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