| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Stress-induced senescence is recently thought to be a barrier against carcinogensis. We previously cloned the phosphoglycerate mutase (PGM) cDNA as senescence bypassing clone. We addressed the question why and how enhanced glycolysis could affect cellular senescence. We planned to clarify the molecular mechanism of regulation and physiological impact of PGM. During these attempt, we cloned a PGM binding protein as a novel ubiquitin ligase, called UBLX1. Also we established PGM transgenic mice model.
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