A study for an essential metabolic shift in glycolytic pathway observed during the transition from cellular senescence to carcinogenesis
| Project/Area Number |
20590696
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kyoto University |
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Principal Investigator |
KONDOH Hiroshi Kyoto University, 医学研究科, 助教 (80402890)
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| Co-Investigator(Kenkyū-buntansha) |
YOKODE Masayuki 京都大学, 医学研究科, 教授 (20252447)
MARUYAMA Takeshi 京都大学, 医学研究科, 研究員 (70467463)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細胞老化 / 癌化 / 解糖系代謝 |
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| Research Abstract |
Stress-induced senescence is recently thought to be a barrier against carcinogensis. We previously cloned the phosphoglycerate mutase (PGM) cDNA as senescence bypassing clone. We addressed the question why and how enhanced glycolysis could affect cellular senescence. We planned to clarify the molecular mechanism of regulation and physiological impact of PGM. During these attempt, we cloned a PGM binding protein as a novel ubiquitin ligase, called UBLX1. Also we established PGM transgenic mice model.
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Report
(4 results)
Research Products
(81 results)
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[Journal Article] HIV-1 Vif interacts with p53 to induce G2 cell cycle arrest and positively regulate viral replication.2011
Author(s)
T Izumi, K Shirakawa, M Matsui, K Io, M Shinohara, M Kawahara, M Kobayashi, H Kondoh, N Misawa, Y Koyanagi, T Uchiyama, A Takaori-Kondo.
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Journal Title
Proc.Nat. Acad. Sci. USA in press
Related Report
Peer Reviewed
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[Journal Article] MDM2 is a novel E3 ligase for HIV-1 Vif.2009
Author(s)
Izumi T, Takaori-Kondo A, Shirakawa K, Higashitsuji H, Itoh K, Io K, Matsui M, Iwai K, Kondoh H, Sato T, Tomonaga M, Ikeda S, Akari H, Koyanagi Y, Fujita J, Uchiyama T.
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Journal Title
NAID
Related Report
Peer Reviewed
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