Diagnosis of early Parkinson's disease in a community-dwelling population sample

• Project/Area Number: 20590698
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tottori University
• Principal Investigator: NAKASHIMA Kenji Tottori University, 医学部, 教授 (70144673)
• Co-Investigator(Renkei-kenkyūsha): WADA Kenji 鳥取大学, 医学部付属病院, 講師 (60346351) ; UEMURA Yusuke 鳥取大学, 医学部付属病院, 助教 (30464291)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 老年医学 / 脳神経疾患 / パーキンソン病 / 早期診断 / アクチグラフ / 高齢者 / 地域 / 質問紙

Research Abstract

Mild parkinsonian signs (MPS) may represent the mild end of a disease spectrum that spans from normal aging to Parkinson's disease or dementia. We conducted a population-based study in a rural island town, Ama-cho. Of the examined subjects, 178 (22.1%) were classified as demonstrating MPS. We established the prevalence of MPS in a community-dwelling elderly population sample in Japan.

Research Products

• [Journal Article] Mild parkinsonian signs in a community-dwelling elderly population sample in Japan. (2011)
  • Author(s): Uemura Y, Wada-Isoe K, Nakashita S, Nakashima K.
  • Journal Title: Journal of the Neurological Sciences. Vol304 Pages: 61-66
  • Peer Reviewed
• [Journal Article] Mild parkinsonian signs in a community-dwelling elderly population sample in Japan (2011)
  • Author(s): Uemura Y, Wada-Isoe K, Nakashita S, Nakashima K
  • Journal Title: Journal of the Neurological Sciences Volume: 304 Pages: 61-66
  • Peer Reviewed
• [Journal Article] Relationship between ^<123>I-MIBG scintigrams and REM sleep behavior disorder in Parkinson's disease (2010)
  • Author(s): Nomura T, Inoue Y, Hogl B, Uemura Y, Kitayama K, Abe T, Miyoshi H, Nakashima K
  • Journal Title: Parkinsonism and Related Disorders Volume: 16 Pages: 683-685
  • Peer Reviewed
• [Journal Article] 認知症/AD/MCIの疫学-現在と将来予測- (2010)
  • Author(s): 和田健二、山脇美香、中島健二
  • Journal Title: Progress in Medicine Volume: 30 Pages: 2081-2086
• [Journal Article] Validation of the Parkinson's disease sleep scale in Japanese patients : A comparison study using the Pittsburgh Sleep Scale Quality Index, the Epworth Sleepiness Scale and Polysomonography. (2009)
  • Author(s): Uemura Y, Nomura T, Inoue Y, Yamawaki M, Yasui K, Nakashima K.
  • Journal Title: Journal of the Neurological Sciences. Vol287 Pages: 36-40
  • Peer Reviewed
• [Journal Article] Prevalence of dementia in the rural island town of Ama-cho, Japan. (2009)
  • Author(s): Wada-Isoe K, Uemura Y, Suto Y, Doi K, Imamura K, Hayashi A, Kitayama M, Watanabe Y, Adachi Y, Nakashima K.
  • Journal Title: Neuroepidemiology Vol32 Pages: 101-106
  • Peer Reviewed
• [Journal Article] Validation of the Parkinson's disease sleep scale in Japanese patients : A comparison study using the Pittsburgh Sleep Scale Quality Index, theEpworth Sleepiness Scale and Polysomonography (2009)
  • Author(s): Uemura Y, Nomura T, Inoue Y, Yamawaki M, Yasui K, Nakashima K
  • Journal Title: Journal of the Neurological Sciences 287 Pages: 36-40
  • Peer Reviewed
• [Journal Article] Endogenous catecholamine enhances the dysfunction of unfolded protein response and α-synuclein oligomerization in PC12 cells overe xpressing human α-synuclein (2009)
  • Author(s): Ito S, Nakaso K, Imamura K, Takeshima T, Nakashima K
  • Journal Title: Neuroscience Research 66 Pages: 124-130
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies common variants at fourloci as genetic risk factors for Parkinson's disease (2009)
  • Author(s): Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawashima H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T
  • Journal Title: Nature Genetics 41 Pages: 1303-1307
  • Peer Reviewed
• [Journal Article] Prevalence of dementia in the rural island town of Ama-cho, Japan (2009)
  • Author(s): Wada-Isoe K, Uemura Y, Suto Y, Doi K, Imamura K, Hayashi A, Kitayama M, Watanabe Y, Adachi Y, Nakashima K
  • Journal Title: Neuroepidemiology 32 Pages: 101-106
  • Peer Reviewed
• [Journal Article] Changes in prevalence and incidence of Parkinson's disease in Japan during a quarter of a century (2009)
  • Author(s): Yamawaki M, Kusumi M, Kowa H, Nakashima K
  • Journal Title: Neuroepidemiology 32 Pages: 263-269
  • Peer Reviewed
• [Journal Article] Serum heart-fatty acid binding protein levels in patients with Lewy body disease (2008)
  • Author(s): Wada-Isoe K, Imamura K, Kitamaya M, Kowa H, Nakashima K
  • Journal Title: Journal of Neurological Sciences 266 Pages: 20-24
  • Peer Reviewed
• [Presentation] 地域における老年期の自覚的もの忘れと睡眠障害、うつ状態の実態調査 (2010)
  • Author(s): 植村佑介, ら
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2010-06-24
• [Presentation] 地域におけるパーキンソン病および軽度パーキンソン徴候の疫学的検討 (2010)
  • Author(s): 植村佑介, ら
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2010-05-20
• [Presentation] 地域における健忘型MCIの運動機能評価 (2010)
  • Author(s): 植村佑介, ら
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: ウインク愛知(名古屋)
• [Presentation] 島根県海士町における認知症および健忘型MCIの疫学的検討 (2010)
  • Author(s): 和田健二, ら
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: ウインク愛知(名古屋)
• [Presentation] 地域におけるアクチグラフィーを用いた軽度パーキンソン徴候の疫学的検討 (2009)
  • Author(s): 植村佑介, ら
  • Organizer: 第3回パーキンソン病・運動障害コングレス
  • Place of Presentation: 品川プリンスホテル(東京)
  • Year and Date: 2009-10-09
• [Presentation] 島根県隠岐郡海士町における認知症疫学調査 (2008)
  • Author(s): 和田健二, ら
  • Organizer: 第27回日本認知症学会
  • Place of Presentation: 前橋テルサ(前橋)
  • Year and Date: 2008-10-10
• [Presentation] 島根県隠岐郡海士町における認知症疫学調査 (2008)
  • Author(s): 和田健二, 植村祐介, 周藤豊, 土井浩二, 今村恵子, 林愛, 北山通朗, 渡辺保裕, 足立芳樹, 中島健二
  • Organizer: 第27回日本認知症学会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-10