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Diagnosis of early Parkinson's disease in a community-dwelling population sample

Research Project

Project/Area Number 20590698
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionTottori University

Principal Investigator

NAKASHIMA Kenji  Tottori University, 医学部, 教授 (70144673)

Co-Investigator(Renkei-kenkyūsha) WADA Kenji  鳥取大学, 医学部付属病院, 講師 (60346351)
UEMURA Yusuke  鳥取大学, 医学部付属病院, 助教 (30464291)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords老年医学 / 脳神経疾患 / パーキンソン病 / 早期診断 / アクチグラフ / 高齢者 / 地域 / 質問紙
Research Abstract

Mild parkinsonian signs (MPS) may represent the mild end of a disease spectrum that spans from normal aging to Parkinson's disease or dementia. We conducted a population-based study in a rural island town, Ama-cho. Of the examined subjects, 178 (22.1%) were classified as demonstrating MPS. We established the prevalence of MPS in a community-dwelling elderly population sample in Japan.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (19 results)

All 2011 2010 2009 2008

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (7 results)

  • [Journal Article] Mild parkinsonian signs in a community-dwelling elderly population sample in Japan.2011

    • Author(s)
      Uemura Y, Wada-Isoe K, Nakashita S, Nakashima K.
    • Journal Title

      Journal of the Neurological Sciences. Vol304

      Pages: 61-66

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mild parkinsonian signs in a community-dwelling elderly population sample in Japan2011

    • Author(s)
      Uemura Y, Wada-Isoe K, Nakashita S, Nakashima K
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 304 Pages: 61-66

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between ^<123>I-MIBG scintigrams and REM sleep behavior disorder in Parkinson's disease2010

    • Author(s)
      Nomura T, Inoue Y, Hogl B, Uemura Y, Kitayama K, Abe T, Miyoshi H, Nakashima K
    • Journal Title

      Parkinsonism and Related Disorders

      Volume: 16 Pages: 683-685

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 認知症/AD/MCIの疫学-現在と将来予測-2010

    • Author(s)
      和田健二、山脇美香、中島健二
    • Journal Title

      Progress in Medicine

      Volume: 30 Pages: 2081-2086

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Validation of the Parkinson's disease sleep scale in Japanese patients : A comparison study using the Pittsburgh Sleep Scale Quality Index, the Epworth Sleepiness Scale and Polysomonography.2009

    • Author(s)
      Uemura Y, Nomura T, Inoue Y, Yamawaki M, Yasui K, Nakashima K.
    • Journal Title

      Journal of the Neurological Sciences. Vol287

      Pages: 36-40

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of dementia in the rural island town of Ama-cho, Japan.2009

    • Author(s)
      Wada-Isoe K, Uemura Y, Suto Y, Doi K, Imamura K, Hayashi A, Kitayama M, Watanabe Y, Adachi Y, Nakashima K.
    • Journal Title

      Neuroepidemiology Vol32

      Pages: 101-106

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Validation of the Parkinson's disease sleep scale in Japanese patients : A comparison study using the Pittsburgh Sleep Scale Quality Index, theEpworth Sleepiness Scale and Polysomonography2009

    • Author(s)
      Uemura Y, Nomura T, Inoue Y, Yamawaki M, Yasui K, Nakashima K
    • Journal Title

      Journal of the Neurological Sciences 287

      Pages: 36-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous catecholamine enhances the dysfunction of unfolded protein response and α-synuclein oligomerization in PC12 cells overe xpressing human α-synuclein2009

    • Author(s)
      Ito S, Nakaso K, Imamura K, Takeshima T, Nakashima K
    • Journal Title

      Neuroscience Research 66

      Pages: 124-130

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies common variants at fourloci as genetic risk factors for Parkinson's disease2009

    • Author(s)
      Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawashima H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T
    • Journal Title

      Nature Genetics 41

      Pages: 1303-1307

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of dementia in the rural island town of Ama-cho, Japan2009

    • Author(s)
      Wada-Isoe K, Uemura Y, Suto Y, Doi K, Imamura K, Hayashi A, Kitayama M, Watanabe Y, Adachi Y, Nakashima K
    • Journal Title

      Neuroepidemiology 32

      Pages: 101-106

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in prevalence and incidence of Parkinson's disease in Japan during a quarter of a century2009

    • Author(s)
      Yamawaki M, Kusumi M, Kowa H, Nakashima K
    • Journal Title

      Neuroepidemiology 32

      Pages: 263-269

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum heart-fatty acid binding protein levels in patients with Lewy body disease2008

    • Author(s)
      Wada-Isoe K, Imamura K, Kitamaya M, Kowa H, Nakashima K
    • Journal Title

      Journal of Neurological Sciences 266

      Pages: 20-24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 地域における老年期の自覚的もの忘れと睡眠障害、うつ状態の実態調査2010

    • Author(s)
      植村佑介, ら
    • Organizer
      第52回日本老年医学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 地域におけるパーキンソン病および軽度パーキンソン徴候の疫学的検討2010

    • Author(s)
      植村佑介, ら
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 地域における健忘型MCIの運動機能評価2010

    • Author(s)
      植村佑介, ら
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      ウインク愛知(名古屋)
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 島根県海士町における認知症および健忘型MCIの疫学的検討2010

    • Author(s)
      和田健二, ら
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      ウインク愛知(名古屋)
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 地域におけるアクチグラフィーを用いた軽度パーキンソン徴候の疫学的検討2009

    • Author(s)
      植村佑介, ら
    • Organizer
      第3回パーキンソン病・運動障害コングレス
    • Place of Presentation
      品川プリンスホテル(東京)
    • Year and Date
      2009-10-09
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 島根県隠岐郡海士町における認知症疫学調査2008

    • Author(s)
      和田健二, ら
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      前橋テルサ(前橋)
    • Year and Date
      2008-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 島根県隠岐郡海士町における認知症疫学調査2008

    • Author(s)
      和田健二, 植村祐介, 周藤豊, 土井浩二, 今村恵子, 林愛, 北山通朗, 渡辺保裕, 足立芳樹, 中島健二
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      前橋
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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