Inhibitory effects of natural products on UVB irradiation-induced carcinogenesis and its mechanism
| Project/Area Number |
20590700
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Ehime University |
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Principal Investigator |
KIMURA Yoshiyuki Ehime University, 大学院・医学系研究科, 講師 (20294796)
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| Co-Investigator(Renkei-kenkyūsha) |
SUMIYOSHI Maho 愛媛大学, 大学院・医学系研究科, 研究員 (60444767)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 癌 / 植物成分 / 薬理学 / 老化 / UVB / 天然薬物 / MMP類発現 / VEGF産生 / DNA損傷 / COX-2発現 / NF-κB発現 / 発癌 / 光老化 / MMP-2発現 / MMP-9発現 / 皮膚障害 / アポトーシス / 皮膚の肥厚 / TGF-β1 |
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| Research Abstract |
Red Ginseng (ginsenoside Rb_1), turmeric, olive leaf extract (main component, oleuropein), Scutellariae radix (main component, baiclein and wogonin) inhibited the increase in skin thickness and wrinkle, and the reduction in skin elasticity induced by UVB irradiation. It is clarified that the inhibitory action of these substances may be due to the inhibition of the levels of MMPs and COX-2 expression, VEGF production, and DNA damage. Among these substances, we found that oleuropein inhibited the chronic UVB irradiation-induced skin carcinogenesis.
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Report
(4 results)
Research Products
(27 results)
