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Inhibitory effects of natural products on UVB irradiation-induced carcinogenesis and its mechanism

Research Project

Project/Area Number 20590700
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionEhime University

Principal Investigator

KIMURA Yoshiyuki  Ehime University, 大学院・医学系研究科, 講師 (20294796)

Co-Investigator(Renkei-kenkyūsha) SUMIYOSHI Maho  愛媛大学, 大学院・医学系研究科, 研究員 (60444767)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords癌 / 植物成分 / 薬理学 / 老化 / UVB / 天然薬物 / MMP類発現 / VEGF産生 / DNA損傷 / COX-2発現 / NF-κB発現 / 発癌 / 光老化 / MMP-2発現 / MMP-9発現 / 皮膚障害 / アポトーシス / 皮膚の肥厚 / TGF-β1
Research Abstract

Red Ginseng (ginsenoside Rb_1), turmeric, olive leaf extract (main component, oleuropein), Scutellariae radix (main component, baiclein and wogonin) inhibited the increase in skin thickness and wrinkle, and the reduction in skin elasticity induced by UVB irradiation. It is clarified that the inhibitory action of these substances may be due to the inhibition of the levels of MMPs and COX-2 expression, VEGF production, and DNA damage. Among these substances, we found that oleuropein inhibited the chronic UVB irradiation-induced skin carcinogenesis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009 2008

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (8 results)

  • [Journal Article] Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice.2011

    • Author(s)
      Kimura Y, Sumiyoshi M.
    • Journal Title

      Ear J Pharmacol in print

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice2011

    • Author(s)
      Y.Kimura, M.Sumiyoshi
    • Journal Title

      European Journal of Pharmacology

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] French maritime pine bark (Pinus maritime Lam.) extract (flavangenol) prevents chronic UVB radiation-induced skin damage and carcinogenesis in melanin-possessing hairless mice.2010

    • Author(s)
      Kimura Y, Sumiyoshi M.
    • Journal Title

      86

      Pages: 955-963

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of olive leaf extract and its main component oleuropein on acute ultraviolet B irradiation-induced skin changes in C57BL/6J mice.2010

    • Author(s)
      Sumiyoshi M, Kimura Y.
    • Journal Title

      Phytother Res 24

      Pages: 995-1003

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of olive leaf extract and its main component oleuropein on acute ultraviolet B irradiation-induced skin changes in C57BL/6J mice2010

    • Author(s)
      M.Sumiyoshi, Y.Kimura
    • Journal Title

      Phytotherapy Research

      Volume: 24 Pages: 995-1003

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] French maritime pine bark(Pinus maritime Lam.)extract(Flavangenol)prevents chronic UVB radiation-induced skin damage and carcinogenesis in melanin-possessing hairless mice2010

    • Author(s)
      Y.Kimura, M.Sumiyoshi
    • Journal Title

      Photochemistry and Photobiology

      Volume: 86 Pages: 955-963

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a turmeric extract (Curcuma longa)on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice.2009

    • Author(s)
      Sumiyoshi M, Kimura Y.
    • Journal Title

      Phytomed 16

      Pages: 1137-1143

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice.2009

    • Author(s)
      Kimura Y, Sumiyoshi M.
    • Journal Title

      J Nutr 139

      Pages: 2079-2086

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ginseng saponins isolated from red ginseng on ultraviolet B-indued skin aging in hairless mice.2009

    • Author(s)
      Kim YG, Sumiyoshi M, Sakanaka M, Kimura Y.
    • Journal Title

      Ear J Pharmacol 602

      Pages: 148-156

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced photoaging in melanin-possessing hairless mice.2009

    • Author(s)
      Sumiyoshi M, Hayashi T, Kimura Y.
    • Journal Title

      J Nat Med 63

      Pages: 130-136

    • NAID

      10025825902

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a turmeric extract(Curcuma longs)on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice2009

    • Author(s)
      M.Sumiyoshi, Y.Kimura
    • Journal Title

      Phtytomedicine 16

      Pages: 1137-1143

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice2009

    • Author(s)
      Y.Kimura, M.Sumiyoshi
    • Journal Title

      Journal of Nutrition 139

      Pages: 2079-2086

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice2009

    • Author(s)
      Y.G.Kim, M.Sumiyoshi, M.Sakanaka, Y.Kimura
    • Journal Title

      European Journal of Pharmacology 602

      Pages: 148-156

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced photoaging in melanin-possessing hairless mice2009

    • Author(s)
      M.Sumiyoshi, T.Hayashi, Y.Kimura
    • Journal Title

      Journal of Natural Medicine 63

      Pages: 130-136

    • NAID

      10025825902

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of olive leaf extract and its main component oleuropein on acute ultraviolet B irradiation-induced skin changes in C57BL/6J mice2009

    • Author(s)
      M.Sumiyoshi, Y.Kimura
    • Journal Title

      Phytotherapy Research

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Red ginseng exyract on ultraviolet B-irradiated skin change in C57BL mice.2009

    • Author(s)
      Y. G. Kim, M. Sumiyoshi, K. Kawahira, M. Sakanaka, Yoshiyuki Kimura
    • Journal Title

      Phytotherapy Research 22

      Pages: 1423-1427

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice2009

    • Author(s)
      Y. G. Kim, M. Sumiyoshi, M. Sakanaka, Yoshiyuki Kimura
    • Journal Title

      European Journal of Pharmacology 6002

      Pages: 148-156

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the nonsugar fraction of brown sugar on chronic ultraviolet Birradiation-induced photoaging in melanin-possessing hairless mice2009

    • Author(s)
      M. Sumiyoshi, T. Hayashi, Yoshiyuki Kimura
    • Journal Title

      Journal of Natural Medicine 63

      Pages: 130-136

    • NAID

      10025825902

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kim YG, Sumiyoshi M, Kawahira K, Sakanaka M, Kimura Y. Effects of red ginseng extract on ultraviolet B-irradiated skin change in C57BL mice.2008

    • Author(s)
      Kim YG, Sumiyoshi M, Kawahira K, Sakanaka M, Kimura Y.
    • Journal Title

      Phytother Res 22

      Pages: 1423-1427

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 漢薬・黄〓中のFlavonoid成分の急性UVB照射による皮膚障害に対する影響2010

    • Author(s)
      木村善行、住吉真帆
    • Organizer
      第27回和漢医薬学会学術大会
    • Place of Presentation
      京都薬科大学(京都)
    • Year and Date
      2010-08-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 漢薬・黄琴中のFlavonoid成分の急性UVB照射による皮膚障害に対する影響2010

    • Author(s)
      木村善行、住吉真帆
    • Organizer
      第27回和漢医薬学会学術大会
    • Place of Presentation
      京都薬科大学(京都)
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 紫外線B波照射による皮膚発癌および皮膚障害に及ぼす各種食用生薬の影響2009

    • Author(s)
      木村善行、住吉真帆
    • Organizer
      第3回食品薬学シンポジウム
    • Place of Presentation
      近畿大学(大阪)
    • Year and Date
      2009-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 紫外線B波照射による皮膚発癌および皮膚障害に及ぼす各種食用生薬の影響について2009

    • Author(s)
      木村善行, 住吉真帆
    • Organizer
      第3回 食品薬学シンポジウム
    • Place of Presentation
      近畿大学(大阪)
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低用量長期UVB照射による皮膚老化に対する黒砂糖中の非ショ糖分画の影響2008

    • Author(s)
      木村善行、住吉真帆、林輝明
    • Organizer
      日本生薬学会第55回年回
    • Place of Presentation
      長崎大学(長崎)
    • Year and Date
      2008-09-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 低用量長期UVB照射による皮膚老化に対するウコンCurcuma longa L.抽出物の影響2008

    • Author(s)
      住吉真帆、木村善行
    • Organizer
      日本生薬学会第55回年回
    • Place of Presentation
      長崎大学(長崎)
    • Year and Date
      2008-09-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 低用量長期UVB照射による皮膚老化に対する黒砂糖中の非ショ糖分画の影響2008

    • Author(s)
      木村善行, 住吉真帆, 林輝明
    • Organizer
      日本生薬学会(第55回年会)
    • Place of Presentation
      長崎大学
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低用量長期UVB照射による皮膚老化に対するウコンCurcuma longa L. 抽出物の影響2008

    • Author(s)
      住吉真帆, 木村善行
    • Organizer
      日本生薬学会(第55回年会)
    • Place of Presentation
      長崎大学
    • Year and Date
      2008-09-19
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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