| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Circulating erythrocytes are constantly exposed to oxidative stress as a result of the high cellular concentration of oxygen and hemoglobin, which is a source of the reactive oxygen species. Exposure to oxidative stress dramatically alters the function of the erythrocyte membrane, such as elevation of viscosity, decrease of deformability. Saponins (especially ginsenosides Rg2 & Rh1) from Ginseng Panax protect the rheological functions of erythrocytes against oxidative stress by preventing the oxidation of SH-groups in band 3 protein. The glucose metabolism were suggested to participate in mechanism of protections.
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