Elucidating mechanism of protection of saponins from Ginseng Panax against oxidative stress.
Project/Area Number |
20590701
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | Ehime University |
Principal Investigator |
SUZUKI Yoji Ehime University, 大学院・医学系研究科, 講師 (20226567)
|
Co-Investigator(Kenkyū-buntansha) |
MITSUDA Noriaki 愛媛大学, 大学院・医学系研究科, 教授 (10314329)
OKUBO Nobutaka 愛媛大学, 大学院・医学系研究科, 講師 (10432791)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 老年医学 / 酸化ストレス / 赤血球 / 紅参由来サポニン / 血液レオロジー / アンチエイジング |
Research Abstract |
Circulating erythrocytes are constantly exposed to oxidative stress as a result of the high cellular concentration of oxygen and hemoglobin, which is a source of the reactive oxygen species. Exposure to oxidative stress dramatically alters the function of the erythrocyte membrane, such as elevation of viscosity, decrease of deformability. Saponins (especially ginsenosides Rg2 & Rh1) from Ginseng Panax protect the rheological functions of erythrocytes against oxidative stress by preventing the oxidation of SH-groups in band 3 protein. The glucose metabolism were suggested to participate in mechanism of protections.
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Report
(4 results)
Research Products
(12 results)