| Project/Area Number |
20590704
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Nagasaki University |
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Principal Investigator |
TAKESHIMA Fuminao Nagasaki University, 医歯薬学総合研究科, 准教授 (70284693)
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| Co-Investigator(Kenkyū-buntansha) |
SEIKO Nakamichi 長崎大学, 医歯薬学総合研究科, 講師 (60457520)
KEITA Inoue 長崎大学, 大学病院, 助教 (20515829)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 禁煙 / 体重増加 / 動脈硬化 / アディポネクチン / インスリン抵抗性 / 血管内皮機能 |
|---|
| Research Abstract |
Fifty habitual male smokers were treated for 2 months, and the 28 subjects who successfully quit smoking were analyzed. Patients were divided into two sub-groups according to their weight change: weight maintainers (n=18) and weight gainers(n=10). In weight gainers, serum adiponection levels were significantly decreased at 9 weeks after the end of treatment. In weight maintainers, adiponectin levels increased gradually after smoking cessation, but changes were not significant. In weight gainers, HOMA-R index was significantly increased at 9 weeks after the end of treatment, while in weight maintainers, HOMA-R index showed no differences throughout the study. Our findings suggest that the adverse effects of weight gain attenuate some of the beneficial effects of smoking cessation.
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