ACTION MECHANISM OF A KAMPO MEDICINE "MAOTO" AGAINST INFLUENZA VIRUS INFECTION
| Project/Area Number |
20590705
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kitasato University |
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Principal Investigator |
NAGAI Takayuki Kitasato University, 大学院・感染制御科学府, 講師 (00172487)
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| Co-Investigator(Kenkyū-buntansha) |
KIYOHARA Hiroaki 北里大学, 大学院・感染制御科学府, 准教授 (70161601)
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| Co-Investigator(Renkei-kenkyūsha) |
ODAGUCHI Hiroshi 北里大学, 東洋医学総合研究所, 室長 (40214150)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 漢方薬 / 麻黄湯 / インフルエンザ / 解熱作用 / 自然抗体 / 東洋医学 / ウイルス / 感染症 / 薬学 / 薬理学 / 解熱 |
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| Research Abstract |
Oral administration of a Kampo medicine "maoto" showed antipyretic activity, and reduced influenza virus (IFV) titers in nasal wash and broncho- alveolar lavage fluid (BALF) of mice at 2 days post infection. Maoto increased anti-IFV antibody titers in nasal wash, BALF and serum at 2 days post infection. Maoto also increased IFV-bound antibody titer in BALF and serum of uninfected mice. These results suggest that maoto shows anti-IFV activity through the increment of natural antibody.
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Report
(4 results)
Research Products
(27 results)
