| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Family with sequence similarity 107 (FAM107) consists of two subtypes of FAM107A and B in mammals. Emerging data regarding FAM107A as a candidate tumor suppressor gene have been accumulated, although few biological information is available about the other FAM107 family protein, FAM107B. We have reported that FAM107B expression was downregulated in cancer and induced by heat-shock stimulation, and designated it as heat shock-inducible tumor small protein (HITS). Since forced expression of HITS inhibited tumor growth, HITS would be a potential tumor suppressor gene, which contrasts with previously described oncogenic activities of other heat shock proteins.
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