| Project/Area Number |
20590712
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kitasato University |
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Principal Investigator |
HANAWA Toshihiko Kitasato University, 東洋医学総合研究所, 所長 (40164892)
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| Co-Investigator(Kenkyū-buntansha) |
HYUGA Sumiko 北里大学, 東洋医学総合研究所・臨床研究部, 室長 (60353471)
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| Co-Investigator(Renkei-kenkyūsha) |
HYUGA Msashi 国立医薬品食品衛生研究所, 生物薬品部, 主任研究官 (50251658)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 漢方薬 / 東洋医学 / 薬剤耐性 / 癌 / 膠原病 / 抗癌剤 / ステロイド / MDR-1 |
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| Research Abstract |
Drug resistance is a problem in the treatment of diseases, such as autoimmune disease and malignancy. MDR-1, a member of drug transporters, causes drug resistance via the exclusion of intracellular drugs. In this study, the kampo medicines suppressed the efflux function of MDR-1, suggesting that the resistance to anticancer drugs or steroidal antiinflammatory drugs may be overcomes by the medicines. The combined application of modern and traditional medicines is expected to be useful for the treatment of drug-refractory diseases.
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