Clarification of the mechanism of EBV-small RNA-mediated gastric carcinogenensis through the activation of innate immune signals.
| Project/Area Number |
20590715
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hokkaido University |
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Principal Investigator |
IWKAIRI Dai Hokkaido University, 遺伝子病制御研究所, 助教 (10307853)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 上部消化管学(食道、胃、十二指腸) / EBV / EBER / 胃がん / TLR3 / 自然免疫 / RLG-I |
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| Research Abstract |
We have demonstrated that EBV-encoded small RNA (EBER) is released by EBV infected lymphocytes and released EBER activates the signaling from toll-like receptor3, a sensor of viral RNA. Our results also suggest that activation of TLR3 signaling by EBER contribute to the pathogenesis of active EBV infection. We also demonstrated that released EBER activates TLR3-mediated signaling in EBV-infected gastric cancer cells.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Editing of EBV-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latency.2010
Author(s)
Iizasa H., Wulff B.E., Alla N.R., Maragkakis M., Megraw M., Hatzigeorgiou A., Iwakiri D., Takada K., Wiedmer A., Showe L., Lieberman P., Nishikura K.
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Journal Title
J Biol Chem. 285
Pages: 33358-70
Related Report
Peer Reviewed
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[Journal Article] Epstein-Barr virus upregulates phosphorylated heat shock protein 27 kDa in carcinoma cells using the phosphoinositide 3-kinase/Akt pathway.2008
Author(s)
Fukagawa Y., Nishikawa J., Kuramitsu Y., Iwakiri D., Takada K., Imai S., Satake M., Okamoto T., Fujimoto M., Okita K., Nakamura K., Sakaida I.
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Journal Title
Electrophoresis 29
Pages: 3192-3200
Related Report
Peer Reviewed
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