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Development of genomics-based prophylaxis strategy for NSIAD ulcer

Research Project

Project/Area Number 20590718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

FURUTA Takahisa  Hamamatsu University School of Medicine, 医学部付属病院, 准教授 (10303546)

Co-Investigator(Kenkyū-buntansha) IKUMA Mutsuhiro  浜松医科大学, 医学部付属病院, 講師 (00275108)
NISHINO Masafumi  浜松医科大学, 医学部, リサーチアシスタント (10436975)
YAMADE Mihoko  浜松医科大学, 医学部, リサーチアシスタント (10464124)
WATANABE Hiroshi  浜松医科大学, 医学部, 教授 (50262803)
OGAWA Noriyoshi  浜松医科大学, 医学部付属病院, 講師 (80308618)
NANBA Hiroki  浜松医科大学, 医学部, 教授 (60198405)
小平 知世  浜松医科大学, 医学部, リサーチアシスタント (40436960)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsNSAID / CYP2C9 / 胃粘膜傷害 / 遺伝子多型 / 個別化療法 / H2S
Research Abstract

We found that CYP2C9^*3 allele was the risk factor for NSAID ulcer. We also developed the ^<13>C-naproxen breath test, which could easily estimate the activity of CYP2C19 in each subject and be a predictive marker of NSAID-induced gastric lesion.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (81 results)

All 2011 2010 2009 Other

All Journal Article (46 results) (of which Peer Reviewed: 20 results) Presentation (30 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Triple therapy with ecabet sodium, amoxicillin and lansoprazole for 2 weeks as the rescue regimen for H.pylori infection.2011

    • Author(s)
      Furuta T, Kato M, Sugimoto M, Sasaki M, Kamoshida T, Furukawa K., Inaba T, Tomita T, Shirai T, Ishii N, Nomura H, Konda Y, Asaka M, the JAPAN GAST STUDY GROUP.
    • Journal Title

      Intern Med 50

      Pages: 369-374

    • Related Report
      2010 Final Research Report
  • [Journal Article] Influence of different proton pump inhibitors on activity of cytochrome P450 assessed by [^<13>C]-aminopyrine breath test.2011

    • Author(s)
      Kodaira C, Shinya Uchida S, Yamade M, Nishino M, Ikuma M, Namiki N, Sugimoto M, Watanabe H, Hishida A, Furuta T.
    • Journal Title

      J Clin Pharmacol [Epub ahead of print].

    • Related Report
      2010 Final Research Report
  • [Journal Article] Randomised clinical trial : a multicentre, double-blind, placebo-controlled study on the efficacy and safety of rabeprazole 5 mg or 10 mg once daily in patients with non-erosive reflux disease.2011

    • Author(s)
      Kinoshita Y, Ashida K, Hongo M, Japan Rabeprazole Study Group for NERD., Takeda H, Kato M, Shimizu Y, Nakagawa S, Nishi K, Yamauchi M, Eda Y, Ohara S, Koike T, Iijima K, Abe Y, Kusano M, Kawamura O, Shimoyama Y, Sekine C, Miwa J, Uemura N, Akiyama J, Furuta T, Shirai N, Niwa Y, Joh T, Kataoka H, Sasaki M, Wada T, Tanida S, Oshima T, Kasugai K, Konagaya T, Tokura Y, Mitsufuji S, Senoo H, Fujiwara Y, Ashida K, Fukuchi T, Habu Y, Sakaguchi M, Inoue K, Adachi K, Furuta K, Tari A, Tani H, Ishii Y, Shimatani T, Inoue M, Tanaka S, Kitadai Y, Ito M, Hiyama T, Yoshida S, Oka S, Manabe N, Ueno Y, Yoshida T, Ryozawa S, Harada T, Fuji T, Harima K, Murakami A, Nishimura S, Kawamura S, Kuniyoshi N, Kuniyoshi K, Matsui T, Noda T, Umezu T, Koganemaru F, Fujimoto K, Iwakiri R.
    • Journal Title

      Aliment Pharmacol Ther. 33(2)

      Pages: 213-224

    • Related Report
      2010 Final Research Report
  • [Journal Article] Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy.2011

    • Author(s)
      Sugimoto M, Nishino M, Kodaira C, Yamade M, Uotani T, Ikuma M, Umemura K, Furuta T.
    • Journal Title

      World J Gastroenterol. 17(14)

      Pages: 1858-1865

    • Related Report
      2010 Final Research Report
  • [Journal Article] Successful treatment of ulcerative colitis complicated by Sweet's syndrome by corticosteroid therapy and leukocytapheresis.2011

    • Author(s)
      Terai T, Sugimoto M, Osawa S, Sugimoto K, Furuta T, Kanaoka S, Ikuma M.
    • Journal Title

      Clin J Gastroenterol 4

      Pages: 151-156

    • Related Report
      2010 Final Research Report
  • [Journal Article] Triple therapy with ecabet sodium, amoxicillin and lansoprazole for 2 weeks as the rescue regimen for H.pylori infection2011

    • Author(s)
      Furuta T*, Kato M, Sugimoto M, Sasaki M, Kamoshida T, Furukawa K, Inaba T, Tomita T, Shirai T, Ishii N, Nomura H, Konda Y, Asaka M
    • Journal Title

      Intern Med

      Volume: 50 Pages: 369-374

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between low-dose aspirin-induced gastric mucosal injury and intragastric pH in healthy volunteers2011

    • Author(s)
      Nishino M, Sugimoto, Kodaira C, Yamade M, Shirai N, Mutsuhiro Ikuma Tanaka T, Sugimura H, Hishida A, Furuta T*
    • Journal Title

      Dig Dis Sci

      Volume: 55 Pages: 1627-1636

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of inflammatory cytokine polymorphisms of IL-2, 4, 6 and 8 on development of gastric cancer and peptic ulcer.2011

    • Author(s)
      Sugimoto M, Yamaoka Y, Furuta T
    • Journal Title

      World J Gastroenterol

      Volume: 16 Pages: 1188-200

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of different proton pump inhibitors on activity of cytochrome P450 assessed by [^<13>C]-aminopyrine breath test2011

    • Author(s)
      Kodaira C, Shinya Uchida S, Yamade M, Nishino M, Ikuma M, Namiki N, Sugimoto M, Watanabe H, Hishida A, Furuta T*
    • Journal Title

      J Clin Pharmacol

      Volume: Mar 17(Epub ahead of prin)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Randomised clinical trial : a multicentre, double-blind, placebo-controlled study on the efficacy and safety of rabeprazole 5mg or 10mg once daily in patients with non-erosive reflux disease.2011

    • Author(s)
      Kinoshita Y, Furuta T, et al.
    • Journal Title

      Aliment Pharmacol Ther

      Volume: 33 Pages: 213-224

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] [13C]-Pantoprazole breath test as the predictor of anti-platelet function of clopidogrel.2010

    • Author(s)
      Furuta T, Iwaki T, Umemura K.
    • Journal Title

      Eur J Clin Pharmacol 66(5)

      Pages: 457-463

    • Related Report
      2010 Final Research Report
  • [Journal Article] Influences of different proton pump inhibitors on the anti-platelet function of clopidogrel in relation to CYP2C19 genotype status.2010

    • Author(s)
      Furuta T, Iwaki T, Umemura K.
    • Journal Title

      Br J Clin Pharmacol. 70(3)

      Pages: 383-392

    • Related Report
      2010 Final Research Report
  • [Journal Article] The dual therapy with 4 times daily dosing of rabeprazole and amoxicillin as the 3rd rescue regimen for eradication of H.pylori2010

    • Author(s)
      Furuta T, Sugimoto M, Kodaira, Nishino M, Yamade M, Uotani T, Ikuma M, Shirai N.
    • Journal Title

      Hepato-Gastroenterology 57(102-103)

      Pages: 1314-1319

    • Related Report
      2010 Final Research Report
  • [Journal Article] Pharmacological aspects of eradication therapy for H.pylori infection.2010

    • Author(s)
      Furuta T, Graham DY.
    • Journal Title

      Gastroenterol Clin North Ame (IF : 2.558) 39

      Pages: 465-480

    • Related Report
      2010 Final Research Report
  • [Journal Article] Esophageal mucosal injury with low-dose aspirin and its prevention by rabeprazole.2010

    • Author(s)
      Sugimoto M, Nishino M, Kodaira C, Yamade M, Ikuma M, Tanaka T, Sugimura H, Hishida A, Furuta T.
    • Journal Title

      J Clin Pharmacol 50(3)

      Pages: 320-330

    • Related Report
      2010 Final Research Report
  • [Journal Article] Relationship between low-dose aspirin-induced gastric mucosal injury and intragastric pH in healthy volunteers.2010

    • Author(s)
      Nishino M, Sugimoto, Kodaira C, Yamade M, Shirai N, Mutsuhiro Ikuma Tanaka T, Sugimura H, Hishida A, Furuta T.
    • Journal Title

      Dig Dis Sci 55(6)

      Pages: 1627-1636

    • Related Report
      2010 Final Research Report
  • [Journal Article] Influence of inflammatory cytokine polymorphisms of IL-2, 4, 6 and 8 on development of gastric cancer and peptic ulcer.2010

    • Author(s)
      Sugimoto M, Yamaoka Y, Furuta T.
    • Journal Title

      World J Gastroenterol 16

      Pages: 1188-1200

    • Related Report
      2010 Final Research Report
  • [Journal Article] Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells.2010

    • Author(s)
      Yamada T, Osawa S, Hamaya Y, Furuta T, Hishida A, Kajimura M, Ikuma M.
    • Journal Title

      Anticancer Res. 30(6)

      Pages: 1953-1960

    • Related Report
      2010 Final Research Report
  • [Journal Article] Preventive Effects of Lansoprazole and Famotidine on Gastric Mucosal Injury Induced by Low-Dose Aspirin in Helicobacter pylori-Negative Healthy Volunteers.2010

    • Author(s)
      Nishino M, Sugimoto M, Kodaira C, Yamade M, Uotani T, Shirai N, Ikuma M, Tanaka T, Sugimura H, Hishida A, Furuta T.
    • Journal Title

      J Clin Pharmacol [Epub ahead of print]

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cecal vanishing tumor associated with cytomegalovirus infection in an immunocompetent elderly adult.2010

    • Author(s)
      Kawasaki S, Osawa S, Sugimoto K, Uotani T, Nishino M, Yamada T, Sugimoto M, Furuta T, Ikuma M.
    • Journal Title

      World J Gastrointest Oncol 2(11)

      Pages: 417-420

    • Related Report
      2010 Final Research Report
  • [Journal Article] Influences of different proton pump inhibitors on the anti-platelet function of clopidogrel in relation to CYP2C19 genotype status.2010

    • Author(s)
      Furuta T*, Iwaki T, Umemura K.
    • Journal Title

      Br J Clin Pharmacol

      Volume: 70 Pages: 383-392

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The dual therapy with 4 times daily dosing of rabeprazole and amoxicillin as the 3rd rescue regimen for eradication of H.pylori2010

    • Author(s)
      Furuta T*, Sugimoto M, Kodaira, Nishino M, Yamade M, Uotani T, Ikuma M, Shirai N.
    • Journal Title

      Hepato-Gastroenterology

      Volume: 57 Pages: 1314-1319

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells2010

    • Author(s)
      Yamada T, Osawa S, Hamaya Y, Furuta T, Hishida A, Kajimura M, Ikuma M.
    • Journal Title

      Anticancer Res.

      Volume: 30 Pages: 953-960

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventive Effects of Lansoprazole and Famotidine on Gastric Mucosal Injury Induced by Low-Dose Aspirin in Helicobacter pylori-Negative Healthy Volunteers.2010

    • Author(s)
      Nishino M, Sugimoto M, Kodaira C, Yamade M, Uotani T, Shirai N, Ikuma M, Tanaka T, Sugimura H, Hishida A, Furuta T*
    • Journal Title

      J Clin Pharmacol

      Volume: Jul 27(Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Esophageal mucosal injury with low-dose aspirin and its prevention by rabeprazole2010

    • Author(s)
      Sugimoto M, Nishino M, Kodaira C, Yamade M, Ikuma M, Tanaka T, Sugimura H, Hishida A, Furuta T
    • Journal Title

      J Clin Pharmacol 50

      Pages: 320-330

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CYP2C19 genotype is associated with symptomatic recurrence of GERD during maintenance therapy with low-dose lansoprazole.2009

    • Author(s)
      Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Ikuma M, Shirai N, Watanabe H, Umemura K, Kimura M, Hishida A.
    • Journal Title

      Eur J Clin Pharmacol 65

      Pages: 693-698

    • Related Report
      2010 Final Research Report
  • [Journal Article] [13C]-pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor, lansoprazole.2009

    • Author(s)
      Furuta T, Kodaira C, Nishino M, Yamade M, Sugimoto M2), Ikuma M, Hishida A, Watanabe H, Umemura K.
    • Journal Title

      Aliment Pharmacol Ther 30

      Pages: 294-300

    • Related Report
      2010 Final Research Report
  • [Journal Article] Helicobacter pylori and Non-malignant Diseases.2009

    • Author(s)
      Furuta T, Delchier CM.
    • Journal Title

      Helicobacter 14(Suppl.1)

      Pages: 29-35

    • Related Report
      2010 Final Research Report
  • [Journal Article] Risk and benefit of proton pump inhibitor for patients undergoing anti-platelet therapy including clopidogrel.2009

    • Author(s)
      Furuta T.
    • Journal Title

      Intern Med 48(21)

      Pages: 1847-1848

    • NAID

      130000122195

    • Related Report
      2010 Final Research Report
  • [Journal Article] Pharmacogenomics in chemotherapy for GI tract cancer.2009

    • Author(s)
      Furuta T.
    • Journal Title

      J Gastroenterol 44

      Pages: 1016-1025

    • NAID

      10025581703

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects.2009

    • Author(s)
      Kodaira C, Sugimoto M, Nishino M, Yamade M, Shirai N, Uchida S, Ikuma M, Yamada S, Watanabe H, Hishida A, Furuta T.
    • Journal Title

      Eur J Clin Pharmacol 65

      Pages: 593-600

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cytokine responses of intraepithelial lymphocytes are regulated by histamine H(2) receptor.2009

    • Author(s)
      akagaki K, Osawa S, Horio Y, Yamada T, Hamaya Y, Takayanagi Y, Furuta T, Hishida A, Ikuma M.
    • Journal Title

      J Gastroenterol. 44(4)

      Pages: 285-296

    • Related Report
      2010 Final Research Report
  • [Journal Article] A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy.2009

    • Author(s)
      Kodaira C, Osawa S, Mochizuki C, Sato Y, Nishino M, Yamada T, Takayanagi Y, Takagaki K, Sugimoto K, Kanaoka S, Furuta T, Ikuma M.
    • Journal Title

      World J Gastroenterol. 15(14)

      Pages: 1774-1778

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prospective study of daily low-dose nedaplatin and continuous 5-fluorouracil infusion combined with radiation for the treatment of esophageal squamous cell carcinoma.2009

    • Author(s)
      Osawa S, Furuta T, Sugimoto K, Kosugi T, Terai T, Yamade M, Takayanagi Y, Nishino M, Hamaya Y, Kodaira C, Yamada T, Iwaizumi M, Takagaki K, Yoshida K, Kanaoka S, Ikuma M.
    • Journal Title

      BMC Cancer 9

      Pages: 408-408

    • NAID

      120005314219

    • Related Report
      2010 Final Research Report
  • [Journal Article] Influence of inflammatory cytokine polymorphisms on eradication rates of Helicobacter pylori.2009

    • Author(s)
      Sugimoto M, Furuta T, Yamaoka Y.
    • Journal Title

      J Gastroenterol Hepatol. 24(11)

      Pages: 1725-1732

    • Related Report
      2010 Final Research Report
  • [Journal Article] CYP2C19 genotype is associated with symptomatic recurrence of GERD during maintenance therapy with low-dose lansoprazole2009

    • Author(s)
      Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Ikuma M, Shirai N, Watanabe H, Umemura K, Kimura M, Hishida A
    • Journal Title

      Eur J Clin Pharmacol 65

      Pages: 693-698

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] [^<13>C]-pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor, lansoprazole2009

    • Author(s)
      Furuta T, Kodaira C, Nishino M, Yamade M, Sugimoto M2), Ikuma M, Hishida A, Watanabe H, Umemura K.
    • Journal Title

      Aliment Pharmacol Ther 30

      Pages: 294-300

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pylori and Non-malignant Diseases2009

    • Author(s)
      Furuta T, Delchier
    • Journal Title

      Helicobacter 14(Sup. 1)

      Pages: 29-35

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk and benefit of proton pump inhibitor for patients under going anti-platelet therapy including clopidogrel2009

    • Author(s)
      Furuta T.
    • Journal Title

      Intern Med 48

      Pages: 1847-1848

    • NAID

      130000122195

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacogenomics in chemotherapy for GI tract cancer2009

    • Author(s)
      Furuta T
    • Journal Title

      J Gastroenterol 44

      Pages: 1016-1025

    • NAID

      10025581703

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects2009

    • Author(s)
      Kodaira C, Sugimoto M, Nishino M, Yamade M, Shirai N, Uchida S, Ikuma M, Yamada S, Watanabe H, Hishida A, Furuta T
    • Journal Title

      Eur J Clin Pharmacol 65

      Pages: 593-600

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective study of daily low-dose nedaplatin and continuous 5-fluorouracil infusion combined with radiation for the treatment of esophageal squamous cell carcinoma2009

    • Author(s)
      Osawa S, Furuta T, Sugimoto K, Kosugi T, Terai T, Yamade M, Takayanagi Y, Nishino M, Hamaya Y, Kodaira C, Yamada T, Iwaizumi M, Takagaki K, Yoshida K, Kanaoka S, Ikuma M.
    • Journal Title

      BMC Cancer 22

      Pages: 408-408

    • NAID

      120005314219

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CYP2C19 genotype is associated with symptomatic recurrence of GERD during maintenance therapy with low-dose lansoprazole2009

    • Author(s)
      Furuta T, Sugimoto M, Kodaira C, Nishino M, Ymade M, Ikutna M, Shirai N, Watanabe H, limemura K, Kimura M, Hishida A
    • Journal Title

      Eur J Clin Pharmacol (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] [^<13>C]-pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor, lansoprazole.2009

    • Author(s)
      Furuta T, Kodaira C, Nishino M, Yamade M, Sugiraoto M^<2)>, Ikuma M, Hishida A, Watanabe H, Umeniura K.
    • Journal Title

      Aliment Pharmacol Ther (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of MDRI C3435T polymorphism on lansoprazole in healthy Japanese subjects.2009

    • Author(s)
      Kodaira C, Sugimoto M, Nishino M, Yamade M, Shirai N, Uchida S, Ikuma M, Yamada S, Watanabe H, Hishida A, Furuta T
    • Journal Title

      Eur J Clin Pharmacol (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resistance of Helicobacter pylori to quinolones and clarithromycin assessed by genetic testing in Japan.

    • Author(s)
      Yamade M, Sugimoto M, Uotani T, Nishino M, Kodaira C, Furuta T.
    • Journal Title

      J Gastroenterol Hepatol (in press)

    • Related Report
      2010 Final Research Report
  • [Presentation] [13C]-naproxen breath test as the predictor of naproxen-induced gastric mucosal injury2010

    • Author(s)
      Kodaira C, Furuta T, Uchida S, Uotani T, Yamade M, Nishino M, Namiki N, Ikuma M, Hishida A..AGA 2010, New Orleans
    • Organizer
      米国消化器病週間(DDW)2010
    • Place of Presentation
      New Orleans
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低用量アスピリンによる食道粘膜傷害と胃内pH2010

    • Author(s)
      杉本光繁, 西野眞史, 小平知世, 山出美穂子, 伊熊睦博, 古田隆久
    • Organizer
      ワークショップ8 NSAIDsと消化管病変 第6回日本消化管学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 13C-ナプロキサン呼気試験によるNSAID潰瘍リスクの検討2010

    • Author(s)
      小平知世, 西野眞史, 山出美穂子, 魚谷貴洋, 杉本健, 大澤恵, 杉本光繁, 伊熊睦博, 内田信也, 古田隆久
    • Organizer
      ワークショップ8 NSAIDsと消化管病変 第6回日本消化管学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] PPIのクロピドグレルの血小板凝集抑制作用に対する影響とCYP2C19遺伝子多型2010

    • Author(s)
      古田隆久, 小平知世, 西野眞史, 山出美穂子, 魚谷貴洋, 杉本光繁, 伊熊睦博, 梅村和夫
    • Organizer
      第6回日本消化管学会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] H. pylori 除菌療法の工夫さらなる除菌率の向上を目指して2009

    • Author(s)
      古田隆久
    • Organizer
      第15回日本ヘリコバクター学会 ランチョンセミナー
    • Place of Presentation
      東京
    • Year and Date
      2009-06-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 当科における進行膵癌に対する集学的治療の検討2009

    • Author(s)
      杉本健, 大澤恵, 寺井智宏, 山出美穂子, 高柳泰宏, 西野眞史, 岩泉守哉, 濱屋寧, 山田貴教, 小平知世, 高垣航輔, 吉田賢一, 金岡繁, 古田隆久, 伊熊睦博
    • Organizer
      シンポジウム : 消化器癌に対する集学的治療日本消化器病学会東海支部第110回例会
    • Place of Presentation
      津
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 術後化学療法中に骨髄癌腫症を来した直腸癌の一例2009

    • Author(s)
      松下直哉, 寺井智宏, 川崎真佑, 魚谷貴洋, 山出美穂子, 高柳泰宏, 西野眞史, 濱屋寧, 小平知世, 岩泉守哉, 山田貴教, 高垣航輔, 杉本健, 大澤恵, 吉田賢一, 金岡繁, 古田隆久, 伊熊睦博
    • Organizer
      日本消化器病学会東海支部第110回例会
    • Place of Presentation
      津
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 消化器内科医師からみた抗血小板薬の安全性と対策2009

    • Author(s)
      古田隆久
    • Organizer
      第95回日本消化器病学会総会ランチョンセミナー11
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胃食道逆流症患者の維持療法期のPPI用量とCYP2C19遺伝子多型2009

    • Author(s)
      古田隆久, 小平知世, 西野眞史
    • Organizer
      パネルディスカッション1 : GERDの維持療法のあり方 第95回日本消化器病学会総会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] H. pylori 陰性若年健常ボランティアの低用量アスピリン短期投与による胃粘膜障害に対するPPIの予防効果と胃内pHの検討2009

    • Author(s)
      西野眞史, 杉本光繁, 古田隆久
    • Organizer
      ワークショップ11 アスピリンと消化管病変 : 第77回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] ダブルバルーン内視鏡を用いた小腸腫瘍診断2009

    • Author(s)
      小平知世, 大澤恵, 松浦愛, 寺井智宏, 山出美穂子, 高柳泰宏, 村松明子, 西野眞史, 濱屋寧, 山田貴教, 岩泉守哉, 高垣航輔, 吉田賢一, 杉本健, 金岡繁, 古田隆久, 伊熊陸博
    • Organizer
      プレナリーセッションPL3-3 第77回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] シタフロキサシンを用いたH. pylori 3次除菌法の検討2009

    • Author(s)
      古田隆久, 小平知世, 西野眞史, 山出美穂子, 杉本光繁
    • Organizer
      シンポジウム3 H. pylori 感染症 3次除菌法の検討 第15回日本ヘリコバクター学会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 健常ボランティアの低容量起因胃粘膜傷害に対するH2RA通常量とPPI半量の予防効果と酸分泌抑制との関係の検討2009

    • Author(s)
      西野眞史, 杉本光繁, 古田隆久
    • Organizer
      シンポジウム8. わが国におけるアスピリン、NSAID消化管傷害の現況と対策 S8-02第51回日本消化器病学会大会 (JDDW2009)
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 消化器内科=循環器内科での院内合同ワークショップの試み2009

    • Author(s)
      伊熊睦博, 西野眞史, 古田隆久
    • Organizer
      ワークショップ15: 消化器内視鏡における安全・危機管理の実際 第78回 日本消化器内視鏡学会総会 (JDDW2009)
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] CYP2C19遺伝子多型の問題点-PPI, clopidogrel を中心に-2009

    • Author(s)
      古田隆久, 梅村和夫
    • Organizer
      シンポジウム8 : 薬剤師の武器をみがこう-薬物動態の基礎と臨床-第19回日本医療薬学会
    • Place of Presentation
      長崎
    • Related Report
      2009 Annual Research Report
  • [Presentation] クロピドグレルの血小板凝集抑制作用に対するPPI併用の影響はCYP2C19遺伝子多型により異なる2009

    • Author(s)
      梅村和夫, 古田隆久
    • Organizer
      シンポジウム6 ゲノム創薬の最新動向と展望 第30回 日本臨床薬理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 13C-Pantoprazole 呼気試験によるCYP2C19タイピングとその臨床応用の可能性-PPI, clopidogrel の効果予測-2009

    • Author(s)
      古田隆久, 梅村和夫
    • Organizer
      シンポジウム15 ファーマコゲノミクスの現状と課題 第30回 日本臨床薬理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Use of the 13C-pantoprazole breath test to predict CYP2C19 phenotype and efficacy of proton pump inhibitors2009

    • Author(s)
      古田隆久, 小平知世, 西野眞史, 山出美穂子, 杉本光繁 伊熊睦博
    • Organizer
      DDW 2009
    • Place of Presentation
      Chicago
    • Related Report
      2009 Annual Research Report
  • [Presentation] Correlation between genetic mutations in 23S rRNA and gyrA of H. pylori strains in Japan2009

    • Author(s)
      山出美穂子, 小平知世, 西野眞史, 伊熊睦博, 古田隆久
    • Organizer
      DDW 2009
    • Place of Presentation
      Chicago
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of low-dose administration of lansoprazole on the gastric mucosal lesions induced by low-dose aspirin in relation to intragastric pH in healthy volunteers with different CYP 2C19 genotypes2009

    • Author(s)
      Nishino M, Sugimoto M, Kodaira C, Yamade M, Ikuma M, Hishida A, Furuta T.
    • Organizer
      DDW 2009
    • Place of Presentation
      Chicago
    • Related Report
      2009 Annual Research Report
  • [Presentation] The dual therapy with 4 times daily dosing of rabeprazole and amoxicillin is effective as the 3rd rescue regimen for eradication of H. pylori2009

    • Author(s)
      Furuta T, Kodaira C, Nishino M, Yamade M, Sugimoto M.
    • Organizer
      European Helicobacter Study Group XXIInd International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Porto, Portugal
    • Related Report
      2009 Annual Research Report
  • [Presentation] [13C]-PANTOPRAZOLE BREATH TEST TO PREDICT EFFICACY OF PROTON PUMP INHIBITOR2009

    • Author(s)
      Furuta T, Kodaira C, Nishino M, Yamade M, Sugimoto M, Ikuma M, Hishida A, Watanabe H, Umemura K.
    • Organizer
      UEGW 2009
    • Place of Presentation
      London
    • Related Report
      2009 Annual Research Report
  • [Presentation] CORRELATION BETWEEN GENETIC MUTATIONS IN 23S RRNA AND GYRASEA OF H. PYLORI STRAINS IN JAPAN2009

    • Author(s)
      M.Yamade, C.Kodaira, M.Nishino, M.Sugimoto, M.Ikuma, T.Furuta.
    • Organizer
      UEGW 2009
    • Place of Presentation
      London
    • Related Report
      2009 Annual Research Report
  • [Presentation] 先進医療によるH. pylori 除菌の現状2009

    • Author(s)
      古田隆久, 小平知世, 西野眞史, 山出美穂子, 伊熊睦博, 菱田明
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] 13C-アミノピリン呼気テストをもちいたプロトンポンプ阻害薬の肝代謝能に及ぼす影響について2009

    • Author(s)
      小平知世, 山出美穂子, 西野眞史, 伊熊陸博, 古田隆久
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] H. pylori の gyrA変異と23SrRNAの変異の関連について2009

    • Author(s)
      山出美穂子, 小平知世, 西野眞史, 伊熊睦博, 菱田明, 古田隆久
    • Organizer
      第15回日本ヘリコバクター学会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 13C-Pantoprazole breath test による3剤PPI/AMPC/CAM療法のH. pylori 除菌成否の検討2009

    • Author(s)
      小平知世, 山出美穂子, 西野眞史, 古田隆久
    • Organizer
      第15回日本ヘリコバクター学会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] シタフロキサシンを用いたH. pylori 3次除菌療法の検討2009

    • Author(s)
      古田隆久, 山出美穂子, 西野眞史, 小平知世, 杉本光繁, 伊熊睦博, 菱田明
    • Organizer
      第51回 日本消化器病学会大会 (JDDW2009)
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] カプセル内視鏡胃排出遅延と腸溶カプセル充填13C-アセテート呼気試験による予測2009

    • Author(s)
      小平知世, 山出美穂子, 西野眞史, 杉本光繁, 杉本健, 大澤恵, 伊熊陸博, 古田隆久
    • Organizer
      第78回 日本消化器内視鏡学会総会 (JDDW2009)
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] H. pylori陰性若年健常ボランティアの低容量アスピリン起因性苛粘膜障害に対する低用量PPIの予防効果と胃内pH、CYP2C19多型の検討2009

    • Author(s)
      西野眞史, 杉本光繁, 山出美穂子, 小平知世, 伊熊睦博, 菱田明, 古田隆久
    • Organizer
      第5回日本消化管学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Book] 消化器内科学 渡辺純夫, 編2010

    • Author(s)
      古田隆久(分担執筆)
    • Total Pages
      350
    • Publisher
      シュプリンガー・ジャパン
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 13C-ナプロキセン呼気試験によるNSAID潰瘍リスクの予測法の確立2009

    • Inventor(s)
      古田隆久
    • Industrial Property Rights Holder
      浜松医科大学
    • Filing Date
      2009
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 13C-ナプロキセン呼気試験によるNSAID潰瘍リスクの予測法の確立2009

    • Inventor(s)
      古田隆久
    • Industrial Property Rights Holder
      国立大学法人浜松医科大学
    • Filing Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 13C-ナプロキセン呼気試験によるNSAID潰瘍リスクの予測法の確立

    • Inventor(s)
      古田隆久
    • Industrial Property Rights Holder
      国立大学法人浜松医科大学
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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