Relationship between reflux vile acids and fatty acid synthase in the pathogenesis of Barrett's esophagus
| Project/Area Number |
20590722
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shimane University |
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Principal Investigator |
AMANO Yuji Shimane University, 医学部, 准教授 (80284032)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | バレット食道 / 発生・分化 / 癌 / パレット食道 |
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| Research Abstract |
FASn expression in Barrett's esophagus was accelerated by the mixture of bile acids and related the malignant potential of Barrett's carcinogenesis. The predictors of FASn expression were refluc esophagitis, intestinal mucin-phenotype, Cdx2 expression, accelerated cellular proliferation inhibited apoptosis (accepted by J Cilin Gastroenterol). Moreover, in the various kinds of bile acids, hydrophobic ones (LCA, GLCA, TLCA) acted as cytotoxic for Barrett's esophagus, and hydrophilic ones (UDCA, GUDCA, TUDCA) did as cytoprotective. Therefore, UDCA administration may protect the Barrett's carinigenesis (accepted by Digestive Liver Disease).
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Report
(4 results)
Research Products
(23 results)
