| Project/Area Number |
20590724
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
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| Research Institution | Shimane University |
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Principal Investigator |
ISHIMURA Norihisa Shimane University, 医学部, 講師 (40346383)
|
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| Research Collaborator |
TAMAGAWA Yuji 島根大学, 医学部, 助教 (20609341)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | シグナル伝達 / 癌 / Notch / Cdx2 / バレット食道 |
|---|
| Research Abstract |
The roles of Notch signaling in the development of Barrett's esophagus remain obscure. In this study, we have demonstrated that Notch related molecule, Hath-1, played an important role in the development of Barrett's esophagus. In the esophageal squamous epithelium, Hes-1, a downstream target of Notch signaling, was upregulated and blocked Hath-1 expression to maintain homeostasis. However, Cdx2 induced by bile acid exposure to the lower esophagus, leaded to Hes-1 downregulation and Hath-1 upregulation. We have shown that Hath-1 was closely associated with goblet cell differentiation in the development of Barrett's esophagus.
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