Effect of central nervous system on small intestinal cell growth And apoptosis
Project/Area Number |
20590728
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Saga University |
Principal Investigator |
KAZUMA Fujimoto Saga University, 医学部, 教授 (50181392)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 視床下部 / 食欲 / 代謝調節 / 消化吸収 / 小腸粘膜増殖 / 生理作用 / 迷走神経 / メタボリック症候群 / 生活習慣 / 中枢神経 / 小腸 / 粘膜 / 増殖機構 / アポトーシス / 摂食中枢 / 満腹中枢 / アミン類 / 糖類 / レプチン / グレリン / 小腸培養 |
Research Abstract |
The aim of this study is to examine if the hypothalamus, central nervous system, regulates mucosal cell growth and apoptosis in the small intestine. Epithelial homeostasis is balanced by regulation of cell proliferation and cell death.Intestinal mucosal apoptosis decreased by the ventromedial hypothalamus lesions,which induced hyperphagia and obesity. In contrast, sustained anorexia induced by administration of anorectic agents increased intestinal apoptosis. These results indicate that the central nervous system, in addition to local factors, is related to regulation of mucosal homeostasis in the intestinal mucosa.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Post-allenge hyperglycemia is a significant risk factor for the development of hepatocellular carcinoma in patients with chronic hepatitis C.2011
Author(s)
Takahashi H, Mizuta T, Eguchi Y, Kawaguchi Y, Kuwashiro T, Oeda S, Isoda H, Oza N, Iwane S, Izumi K, Anzai K, Ozaki I, Fujimoto K.
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Journal Title
J Gastroenterol. [Epub ahead of print]
Related Report
Peer Reviewed
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[Journal Article] The pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease.2011
Author(s)
Eguchi Y, Mizuta T, Sumida Y, Ishibashi E, Kitajima Y, Isoda H, Horie H, Tashiro T, Iwamoto E, Takahashi H, Kwashiorkor T, Soejima S, Kawaguchi Y, Oda Y, Emura S, Iwakiri R, Ozaki I, Euchar T, Ono N, Anza K, Fujimoto K, Koizumi S.
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Journal Title
J Gastroenterol. 46Suppl.1
Pages: 70-78
NAID
Related Report
Peer Reviewed
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[Journal Article] Metabolic factors are associated with serum alanine aminotransferase levels in patients with chronic hepatitis C.2010
Author(s)
Kobayashi Y, Kawaguchi Y, Mizuta T, Kwashiorkor T, Ode S, Ooze N, Takahashi H, Inane S, Euchar Y, Anza K, Ozaki I, Fujimoto K.
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Journal Title
J Gastroenterol. [Epub ahead of print]
NAID
Related Report
Peer Reviewed
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[Journal Article] Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow.2010
Author(s)
Shiraishi R, Iwakiri R, Fujise T, Kuroki T, Kakimoto T, Takashima T, Sakata Y, Tsunada S, Nakashima Y, Yanagita T, Fujimoto K.
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Journal Title
J.Gastroenterol. 45
Pages: 625-635
NAID
Related Report
Peer Reviewed
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[Journal Article] Age-related fat deposition in multifidus muscle could be a marker for nonalcoholic fatty liver disease.2010
Author(s)
Kitajima Y, Eguchi Y, Ishibashi E, Nakashita S, Aoki S, Toda S, Mizuta T, Ozaki I, Ono N, Eguchi T, Arai K, Iwakiri R, Fujimoto K.
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Journal Title
J Gastroenterol. 45
Pages: 218-224
NAID
Related Report
Peer Reviewed
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[Journal Article] Higher arterial stiffness, greater peripheral vascular resistance and lower blood flow in lower-leg arteries are associated with long-term hyperglycaemia in type 2 diabetic patients with normal ankle-brachial index.2009
Author(s)
Suzuki E, Yoshimura T, Omura Y, Sakaguchi M, NishioY, Maegawa H, Hisatomi A, Fujimoto K, Takeda J, Kashiwaki A.
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Journal Title
Diabetes Metab Res Rev 25
Pages: 363-369
Related Report
Peer Reviewed
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[Journal Article] Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche.2009
Author(s)
Ootani A, Li X, Sangiorgi E, Ho OT, Ueno H, Toda S, Sugihara H, Fujimoto K, Weissman IL, Capecchi MR, Kuo CJ.
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Journal Title
Nature Med 15
Pages: 701-706
Related Report
Peer Reviewed
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[Journal Article] Hepatitis C virus infection enhances insulin resistance induced by visceral fat accumulation.2009
Author(s)
Eguchi Y, Mizuta T, Ishibashi E, Kitajima Y, Oza N, Nakashita S, Hara M, Iwane S, Takahashi H, Akiyama T, Ario K, Kawaguchi Y, Yasutake T, Iwakiri R, Ozaki I, Hisatomi A, Eguchi T, Ono T, Fujimoto K.
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Journal Title
Liver Int 29
Pages: 213-220
Related Report
Peer Reviewed
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