• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The significance of nuclear translocation of transcriptional regulatory factor & tumor suppressor, ATBF1, for the malignant nature of gastric cancer.

Research Project

Project/Area Number 20590731
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionNagoya City University

Principal Investigator

KATAOKA Hiromi  Nagoya City University, 大学院・医学研究科, 准教授 (40381785)

Co-Investigator(Kenkyū-buntansha) MIURA Yutaka  名古屋市立大学, 大学院・医学研究科, 准教授 (90285198)
KAWAGUCHI Makoto  名古屋市立大学, 大学院・医学研究科, 研究員 (50204699)
JOU Takashi  名古屋市立大学, 大学院・医学研究科, 教授 (30231369)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords胃癌 / 転写因子 / 癌抑制因子 / ATBF1 / p53 / 転写制御因子 / RUNX3 / 核・細胞質移行
Research Abstract

Transcriptional regulatory factor, ATBF1 associates with RUNX3. The molecular complex of ATBF1 and RUNX3 translocates to the nucleus in response to TGF-β・ signal transduction. ATBF1 and RUNX3 activate the promoter of p21. ATBF1 and RUNX3 complex might function in the nucleus as tumor suppressor and transcriptional regulator.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (17 results)

All 2011 2010 2009 2008

All Journal Article (9 results) (of which Peer Reviewed: 6 results) Presentation (8 results)

  • [Journal Article] Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF・β signal transduction.2010

    • Author(s)
      Mabuchi M, Kataoka H, Miura Y, Kim TS, Kawaguchi M, Ebi M, Tanaka M, Mori Y, Kubota E, Mizushima T, Shimura T, Mizoshita T, Tanida S, Kamiya T, Asai K, Joh T.
    • Journal Title

      Biochem Biophys Res Commun. 23;398(2)

      Pages: 321-325

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胃癌の胃型腸型粘液形質制御における転写因子型癌抑制因子ATBF1の役割2010

    • Author(s)
      片岡洋望, 三浦裕, 馬淵元志, 森義徳, 志村貴也, 溝下勤, 谷田諭史, 神谷武, 川口誠, 城卓志
    • Journal Title

      PROGRESS IN MEDICINE Vol.30(3)

      Pages: 787-790

    • Related Report
      2010 Final Research Report
  • [Journal Article] Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF β signal transduction.2010

    • Author(s)
      Mabuchi M, Kataoka H, et al
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 23;398(2) Pages: 321-325

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胃癌の胃型粘液腸型粘液形質発現における転写制御因子型癌抑制因子ATBF1の役割2010

    • Author(s)
      片岡洋望, 三浦裕, 他
    • Journal Title

      PROGRESS IN MEDICINE 30(3)

      Pages: 787-790

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Lentinan with S-1 and Paclitaxel for gastric cancer chemotherapy improve patient quality of life2009

    • Author(s)
      片岡洋望, et al.
    • Journal Title

      Hepato-Gastroenterology 56(90)

      Pages: 547-550

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EGFR ligands and their signaling scissors, ADAMs, as new molecular targets for anticancer treatments2009

    • Author(s)
      片岡洋望
    • Journal Title

      J Dermatol Sci. 56(3)

      Pages: 148-153

    • NAID

      10027398567

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Lentinan with S-1 and Paclitaxel for gastric cancer chemotherapy improve patient quality of life2009

    • Author(s)
      Kataoka H, et al.
    • Journal Title

      Hepato-Gastroenterology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of proHB-EGF carboxy-terminal fragment nuclear translocation : a new molecular target therapy for gastric cancer.2008

    • Author(s)
      Shimura. T, Kataoka H, et al.
    • Journal Title

      Clin Cancer Res. 15 ; 14(12)

      Pages: 3956-3965

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ING2 as a novel mediator of TGF-beta -dependent responses in epithelial cells.2008

    • Author(s)
      Sarker KP, Kataoka H, et al.
    • Journal Title

      J Biol Chem 283(19)

      Pages: 13269-13279

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 胃癌細胞における転写因子型癌抑制因子ATBF1のTGFbetaによる活性化メカニズム2011

    • Author(s)
      馬渕元志, 片岡洋望, 他
    • Organizer
      第7回日本消化管学会総会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2011-02-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 胃癌細胞における転写因子型癌抑制因子ATBF1のTGFβによる活性化メカニズム2011

    • Author(s)
      馬渕元志, 片岡洋望, 他
    • Organizer
      第7回日本消化管学会総会学術集会
    • Place of Presentation
      京都(国立京都国際会議場)
    • Year and Date
      2011-02-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Tumor suppressor, AT-motif binding factor 1 (ATBF1), translocates to the nucleus with Runt domain transcription factor 3 (RUNX3) in cooperation with TGF-beta signal transduction.(Oncology III)2010

    • Author(s)
      馬渕元志, 片岡洋望, et al.
    • Organizer
      18^<th> United European Gastroenterology Week.
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-10-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Tumor suppressor, AT-motif binding factor 1 (ATBF1), translocates to the nucleus with Runt domain transcription factor 3 (RUNX3) in cooperation with TGF-beta signal transduction.2010

    • Author(s)
      Mabuchi M, Kataoka H., et al
    • Organizer
      18^<th> United European Gastroenterology Week
    • Place of Presentation
      Barcelona, Spain (Centre Convencion Internacional Barcelona)
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃癌における転写因子型癌抑制因子ATBF1の役割-核・細胞質移行の意義-2009

    • Author(s)
      片岡洋望, 馬渕元志, 他
    • Organizer
      第28回消化器病態生理勉強会
    • Place of Presentation
      東京
    • Year and Date
      2009-08-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胃癌における転写因子型癌抑制因子ATBF1の役割-TGFβシグナル伝達系でのRUNX3との共役2009

    • Author(s)
      馬渕元志, 片岡洋望, 他
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 胃癌における転写因子型癌抑制因子ATBF1, RUNX3複合体のTGF-beta1刺激による核・細胞質移行の意義2009

    • Author(s)
      馬淵元志, 片岡洋望, 他
    • Organizer
      第5回日本消化管学会総会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2009-02-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 胃癌における転写因子型癌抑制因子ATBFl, RUNX3複合体のTGF-beta1刺激による核・細胞質移行の意義2009

    • Author(s)
      馬淵元志, 片岡洋望ら
    • Organizer
      第5回日本消化管学会総会学術総会
    • Place of Presentation
      東京, 京王プラザホテル
    • Year and Date
      2009-02-12
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi