The significance of nuclear translocation of transcriptional regulatory factor & tumor suppressor, ATBF1, for the malignant nature of gastric cancer.

• Project/Area Number: 20590731
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagoya City University
• Principal Investigator: KATAOKA Hiromi Nagoya City University, 大学院・医学研究科, 准教授 (40381785)
• Co-Investigator(Kenkyū-buntansha): MIURA Yutaka 名古屋市立大学, 大学院・医学研究科, 准教授 (90285198) ; KAWAGUCHI Makoto 名古屋市立大学, 大学院・医学研究科, 研究員 (50204699) ; JOU Takashi 名古屋市立大学, 大学院・医学研究科, 教授 (30231369)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 胃癌 / 転写因子 / 癌抑制因子 / ATBF1 / p53 / 転写制御因子 / RUNX3 / 核・細胞質移行

Research Abstract

Transcriptional regulatory factor, ATBF1 associates with RUNX3. The molecular complex of ATBF1 and RUNX3 translocates to the nucleus in response to TGF-β・ signal transduction. ATBF1 and RUNX3 activate the promoter of p21. ATBF1 and RUNX3 complex might function in the nucleus as tumor suppressor and transcriptional regulator.

Research Products

• [Journal Article] Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF・β signal transduction. (2010)
  • Author(s): Mabuchi M, Kataoka H, Miura Y, Kim TS, Kawaguchi M, Ebi M, Tanaka M, Mori Y, Kubota E, Mizushima T, Shimura T, Mizoshita T, Tanida S, Kamiya T, Asai K, Joh T.
  • Journal Title: Biochem Biophys Res Commun. 23;398(2) Pages: 321-325
  • Peer Reviewed
• [Journal Article] 胃癌の胃型腸型粘液形質制御における転写因子型癌抑制因子ATBF1の役割 (2010)
  • Author(s): 片岡洋望, 三浦裕, 馬淵元志, 森義徳, 志村貴也, 溝下勤, 谷田諭史, 神谷武, 川口誠, 城卓志
  • Journal Title: PROGRESS IN MEDICINE Vol.30(3) Pages: 787-790
• [Journal Article] Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF β signal transduction. (2010)
  • Author(s): Mabuchi M, Kataoka H, et al
  • Journal Title: Biochem Biophys Res Commun. Volume: 23;398(2) Pages: 321-325
  • Peer Reviewed
• [Journal Article] 胃癌の胃型粘液腸型粘液形質発現における転写制御因子型癌抑制因子ATBF1の役割 (2010)
  • Author(s): 片岡洋望, 三浦裕, 他
  • Journal Title: PROGRESS IN MEDICINE 30(3) Pages: 787-790
• [Journal Article] Lentinan with S-1 and Paclitaxel for gastric cancer chemotherapy improve patient quality of life (2009)
  • Author(s): 片岡洋望, et al.
  • Journal Title: Hepato-Gastroenterology 56(90) Pages: 547-550
  • Peer Reviewed
• [Journal Article] EGFR ligands and their signaling scissors, ADAMs, as new molecular targets for anticancer treatments (2009)
  • Author(s): 片岡洋望
  • Journal Title: J Dermatol Sci. 56(3) Pages: 148-153
  • NAID: 10027398567
• [Journal Article] Lentinan with S-1 and Paclitaxel for gastric cancer chemotherapy improve patient quality of life (2009)
  • Author(s): Kataoka H, et al.
  • Journal Title: Hepato-Gastroenterology (in press)
  • Peer Reviewed
• [Journal Article] Suppression of proHB-EGF carboxy-terminal fragment nuclear translocation : a new molecular target therapy for gastric cancer. (2008)
  • Author(s): Shimura. T, Kataoka H, et al.
  • Journal Title: Clin Cancer Res. 15 ; 14(12) Pages: 3956-3965
  • Peer Reviewed
• [Journal Article] ING2 as a novel mediator of TGF-beta -dependent responses in epithelial cells. (2008)
  • Author(s): Sarker KP, Kataoka H, et al.
  • Journal Title: J Biol Chem 283(19) Pages: 13269-13279
  • Peer Reviewed
• [Presentation] 胃癌細胞における転写因子型癌抑制因子ATBF1のTGFbetaによる活性化メカニズム (2011)
  • Author(s): 馬渕元志, 片岡洋望, 他
  • Organizer: 第7回日本消化管学会総会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2011-02-19
• [Presentation] 胃癌細胞における転写因子型癌抑制因子ATBF1のTGFβによる活性化メカニズム (2011)
  • Author(s): 馬渕元志, 片岡洋望, 他
  • Organizer: 第7回日本消化管学会総会学術集会
  • Place of Presentation: 京都(国立京都国際会議場)
  • Year and Date: 2011-02-19
• [Presentation] Tumor suppressor, AT-motif binding factor 1 (ATBF1), translocates to the nucleus with Runt domain transcription factor 3 (RUNX3) in cooperation with TGF-beta signal transduction.(Oncology III) (2010)
  • Author(s): 馬渕元志, 片岡洋望, et al.
  • Organizer: 18^<th> United European Gastroenterology Week.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-10-27
• [Presentation] Tumor suppressor, AT-motif binding factor 1 (ATBF1), translocates to the nucleus with Runt domain transcription factor 3 (RUNX3) in cooperation with TGF-beta signal transduction. (2010)
  • Author(s): Mabuchi M, Kataoka H., et al
  • Organizer: 18^<th> United European Gastroenterology Week
  • Place of Presentation: Barcelona, Spain (Centre Convencion Internacional Barcelona)
  • Year and Date: 2010-10-27
• [Presentation] 胃癌における転写因子型癌抑制因子ATBF1の役割-核・細胞質移行の意義- (2009)
  • Author(s): 片岡洋望, 馬渕元志, 他
  • Organizer: 第28回消化器病態生理勉強会
  • Place of Presentation: 東京
  • Year and Date: 2009-08-08
• [Presentation] 胃癌における転写因子型癌抑制因子ATBF1の役割-TGFβシグナル伝達系でのRUNX3との共役 (2009)
  • Author(s): 馬渕元志, 片岡洋望, 他
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-08
• [Presentation] 胃癌における転写因子型癌抑制因子ATBF1, RUNX3複合体のTGF-beta1刺激による核・細胞質移行の意義 (2009)
  • Author(s): 馬淵元志, 片岡洋望, 他
  • Organizer: 第5回日本消化管学会総会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-02-12
• [Presentation] 胃癌における転写因子型癌抑制因子ATBFl, RUNX3複合体のTGF-beta1刺激による核・細胞質移行の意義 (2009)
  • Author(s): 馬淵元志, 片岡洋望ら
  • Organizer: 第5回日本消化管学会総会学術総会
  • Place of Presentation: 東京, 京王プラザホテル
  • Year and Date: 2009-02-12