| Project/Area Number |
20590733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
ITO Takahiro Asahikawa Medical College, 医学部, 特任助教 (30396361)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
TANABE Hiroki 旭川医科大学, 医学部, 助教 (50396363)
|
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 免疫学 / 感染症 / 蛋白質 / ストレス |
|---|
| Research Abstract |
The amount of HD5 and HD6 secreted from a single small bowel crypt was estimated. In Crohn's disease patients, the ileal expression of HD5 mRNA was significantly reduced compared with controls. Protein disulfide isomerase (PDI) was expressed in Paneth cells. This study suggested that it was important for disulfide bond formation of defensin. The Paneth cell secretions induced IL-8, TNF-α,IL-1β, IL-13, RANTES and TGF-β1 from T84 cells. Human Paneth cells contribute to innate as well as adaptive immunity by defensin-dependent and -independent processes, which appear to be mediated by induction of pro-inflammatory cytokines. A deficiency of the α-defensins derived from Paneth cells is considered to be associated with various gut diseases, including Crohn's disease.
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