Dynamic status of bacterial products transported by OCTNs or MDR-1 in normal and inflamed intestinal epithelia
Project/Area Number |
20590734
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Asahikawa Medical College |
Principal Investigator |
FUJIYA Mikihiro Asahikawa Medical College, 医学部, 准教授 (80322915)
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Co-Investigator(Kenkyū-buntansha) |
OHTAKE Takaaki 旭川医科大学, 医学部, 講師 (10359490)
MAEMOTO Atsuo 旭川医科大学, 医学部, 客員准教授 (40400113)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 腸内細菌とトランスポーター / MDR-1 / OCTN / Bacillus subtilis / Cometence and sorulation factor / 炎症性腸疾患 / Competence and Sporulation factor / Comnetence and soorulation factor |
Research Abstract |
The mammalian intestines maintain intestinal homeostasis by monitoring the intestinal condition through the recognition of the status of commensal bacteria. However, the mechanisms underlying the host-bacterial interaction are insufficiently understood. The present study proposes novel systems to sense bacterial-derived effecters through epithelial membrane transporters and integrins. This investigation demonstrated that a Lactobacillus brevis SBC88-derived effector was recognized through its binding with epithelial integrins, while a Bacillus subtilis-derived effector, competence and sporulation factor (CSF), was taken up by a membrane transporter, OCTN2. Conversely, the up-taken CSF was partially excreted by MDR-1, but most of the CSF in the cytoplasm was though to have been released by other mechanisms. Taken together, the recognition system for intestinal bacteria appears to be regulated by many molecules, including OCTNs, MDRs and integrins.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] An unusual elevated lesion of the esophagus.2011
Author(s)
Sawada K, Ikuta K, Itabashi K, Suzuki Y, Mizukami Y, Fujiya M, , Kubo K, Tamura Y, Torimoto Y, Kohgo Y
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[Journal Article] Collagenous colitis appeared after the 6-year administration of lansoprazole.2010
Author(s)
Sawada K, Fujiya M, Itabashi K, Suzuki Y, Kubo K, Kashima S, Nomura Y, Nata T, Ueno N, Ishikawa C, Inaba Y, Itoh T, Moriichi K, Okamoto K, Ikuta K, Tanabe H, Mizukami Y, Kohgo Y
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Journal Title
Clin J Gastorol 3
Pages: 18-21
Related Report
Peer Reviewed
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[Journal Article] 麦芽乳酸菌(Lbrevis 8803)死菌の腸管組織に対する生理活性の解明.2010
Author(s)
上野伸展, 瀬川修一, 藤谷幹浩,杉山隆治, 奈田利恵, 野村好樹, 嘉島伸, 石川千里, 稲場勇平, 伊藤貴博, 盛一健太郎, 岡本耕太郎,高後裕
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Journal Title
消化器と免疫
Volume: 46
Pages: 164-167
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[Journal Article] Transnasal ultrathin endoscopy for placement of a long intestinal tube in patients with intestinal obstruction.2008
Author(s)
Sato R, Watari J, Tanabe H, Fujiya M, Ueno N, Konno Y, Ishikawa C, Ito T, Moriichi K, Okamoto K, Maemoto A, Chisaka K, Kitano Y, Matsumoto K, Ashida T, Kono T, Kohgo Y
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Journal Title
Gastrointest Endosc 67(6)
Pages: 953-957
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Peer Reviewed
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[Journal Article] Transnasal ultrathin endoscopy for placement of a long intestinal tube in patients with intestinal obstruction2008
Author(s)
Sato R, Watari J, Tanabe H, Fujiya M, Ueno N, Konno Y, Ishikawa C, Ito T, Moriichi K, Okamoto K, Maemoto A, Chisaka K, Kitano Y, Matsumoto K, Ashida T, Kono T, Kohgo Y.
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Journal Title
Gastrointest Endosc 67(6)
Pages: 953-957
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Peer Reviewed
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[Journal Article] Immunoprecipitation of nucleosomal DNA is a novel procedure to improve the sensitivity of serum screening for the p16 hypermethylation associated with colon cancer.
Author(s)
Sakamoto J, Fujiya M, Okamoto K, Nata T, Inaba Y, Moriichi K, Tanabe H, Mizukami Y, Watari J, Ashida T, Kohgo Y.
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Journal Title
Cancer Epidemiology (in press)
Related Report
Peer Reviewed
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[Journal Article] The expression of the anti-microbial peptide α-defensin/cryptdins inintestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10 deficient mice
Author(s)
Inaba Y, Ashida T, Ito T, Ishikawa C, Tanabe H, Maemoto A, Watari J, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y.
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Journal Title
Inflammatory Bowel Diseases (in press)
Related Report
Peer Reviewed
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[Journal Article] Obscure gastrointestinal bleeding from vascular lesions formed by venous and lymphatic congestion due to post-operative adhesion and subsequent mesenteric torsion 50 years after appendectomy.
Author(s)
Kashima S, Nata T, Fujiya M, Moriichi K, Nomura Y, Ueno N, Itabashi K, Ishikawa C, Inaba Y, Ito T, Okamoto K, Mizukami Y, Ebisawa Y, Chisato N, Kono T, Tokusashi Y, Miyokawa N, Yamada M, Kohgo Y.
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Related Report
Peer Reviewed
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[Journal Article] 麦芽乳酸菌(L.brevis 8803)死菌の腸管組織に対する生理活性の解明
Author(s)
上野伸展, 瀬川修一, 藤谷幹浩, 杉山隆治, 奈田利恵, 野村好紀, 嘉島伸, 石川千里, 稲場勇平, 伊藤貴博, 盛一健太郎, 岡本耕太郎, 高後裕
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[Presentation] Competence and Sporulation Factor Derived From Bacillus Subtilis Improves Epithelial Cell Injury in Intestinal Inflammation via Immunomodulation and Cytoprotection.2010
Author(s)
Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H, Mizukami Y, Chang EB, Kohgo Y
Place of Presentation
New Orleans
Year and Date
2010-05-05
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[Presentation] Heat-Killed Body of Lactobacillus brevis SBC8803 Contributes to Maintain Intestinal Homeostasis and Improve Intestinal Injury in a Murine Model of Colitis.2010
Author(s)
Ueno N, Fujiya M, Segawa S, Nata T, Inaba Y, Moriichi K, Tanabe H, Mizukami Y, Kobayashi N, Ito K, Kohgo Y
Organizer
DDW 2010 (AGA)
Place of Presentation
New Orleans
Year and Date
2010-05-04
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[Presentation] Heat-Kiled Body of Lactobacillus brevis SBC8803 Contributes to Maint ain Intestinal Homeostasis and Improve Intestinal Injury in a Murine Model of Colitis.2010
Author(s)
Ueno N, Fuiiya M, Segawa S, Nata T, Inaba Y, Moriichi K, Tanabe H, Mizukami Y, Kobayashi N, Ito K, Kohgo Y
Organizer
DDW 2010(AGA)
Place of Presentation
New Orleans
Year and Date
2010-05-04
Related Report
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[Presentation] Autofluorescence Imaging Can Evaluate the Dysplastic Grade of a Colonic Neoplasm by Detecting the Nucleus Enlargement of Tumor Cells.2010
Author(s)
Moriichi K, Fujiya M, Sato R, Nata T, Nomura Y, Ueno N, Ishikawa C, Inaba Y, Ito T, Okamoto K, Tanabe H, Watari J, Saitoh Y, Kohgo Y
Place of Presentation
New Orleans
Year and Date
2010-05-03
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[Presentation] 新規麦芽乳酸菌の腸管に対する生理活性の解明2009
Author(s)
上野伸展, 瀬川修一, 藤谷幹浩, 杉山隆治, 奈田利恵, 野村好紀, 嘉島伸, 石川千里, 稲場勇平, 伊藤貴博, 盛一健太郎, 岡本耕太郎, 高後裕
Organizer
第46回日本消化器免疫学会総会
Place of Presentation
松山
Year and Date
2009-07-24
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[Presentation] Infliximab may prevent post-operative recurrences in Crohn's disease.2009
Author(s)
K.Okamoto, T.Ashida, R.Sugiyama, T.Nata, Y.Nomura, N.Ueno, C.Ishikawa, Y.Inaba, T.Ito, K.Moriihi, H.Tanabe, M.Fujiya, Y.Kohgo
Organizer
DDW 2009(AGA)
Place of Presentation
Chicago
Year and Date
2009-06-01
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[Patent(Industrial Property Rights)] 腸管保護剤2011
Inventor(s)
高後裕,藤谷幹浩,上野伸展,瀬川修一,小林直之
Industrial Property Rights Holder
国立大学法人旭川医科大学,サッポロビール株式会社
Industrial Property Number
特許権,PCT/JP2011/057689
Filing Date
2011-03-28
Related Report
Overseas
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[Patent(Industrial Property Rights)]2010
Inventor(s)
高後裕,藤谷幹浩,上野伸展,瀬川修一,小林直之
Industrial Property Rights Holder
国立大学法人旭川医科大学,サッポロビール株式会社
Patent Publication Number
特許権,特開2010-083881
Acquisition Date
2010-04-15
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[Patent(Industrial Property Rights)] 特許2010
Inventor(s)
高後裕, 藤谷幹浩, 上野伸展, 瀬川修一, 小林直之
Industrial Property Rights Holder
国立大学法人旭川医科大学,サッポロビール株式会社
Industrial Property Number
特願2010-089469,PCT/JP2011/057689
Filing Date
2010-04-08
Acquisition Date
2011-03-28
Related Report
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