| Project/Area Number |
20590739
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
TSUJIKAWA Tomoyuki Shiga University of Medical Science, 医学部, 教授 (80273407)
|
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| Co-Investigator(Kenkyū-buntansha) |
FUJIYAMA Yoshihide 滋賀医科大学, 医学部, 教授 (70111896)
ANDOH Akira 滋賀医科大学, 大学院・医学研究科, 教授 (90252395)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
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| Keywords | 脂肪乳剤 / クローン病 / TNF-α / RT-PCR / タローン病 / 脂肪酸 / 小腸内視鏡 |
|---|
| Research Abstract |
To make clear that a high-fat food intake involves Crohn disease aggravation directly, I scattered fat into the ileum end during small intestinal endoscopy and compared mucosal cytokine (TNF-α) levels in between pre and post fat stimulation. The levels of TNF-α mRNA in many cases decreased after the fat stimulation, contrary to my expectation. Therefore, it was suggested that the immunoresponse in the mucosa control possibility the local inflammation in Crohn disease.
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