Usefulness of insulin-like growth factor as a therapeutic target for the gastrointestinal malignancies.

• Project/Area Number: 20590740
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: MIYAMOTO Shinichi Kyoto University, 医学研究科, 助教 (90378761)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 分子標的療法 / インスリン様増殖因子 / 中和抗体 / 家族性大腸腺腫症 / 癌 / シグナル伝達 / 分子標的薬 / 増殖因子

Research Abstract

The insulin-like growth factors (IGFs) were multifunctional growth factor involved in the development, growth and survival of tumor cells. Familial adenomatous polyposis (FAP) develops a large number of pre-malignant adenomatous polyps during adolescence which become colon cancers at high rates. IGF-I or IGF-II neutralizing antibody was administered to FAP model mouse and each antibody significantly reduced the number of small intestinal polyp, respectively. Combination administration in the effective dose of each antibody had the synergistic effect. Our findings demonstrate that IGFs in the tumor microenvironment play a crucial role for the colon tumorigenesis and may be the promising therapeutic target.

Research Products

• [Journal Article] Ligand-specific antibodies to insulin-like growth factors suppress intestinal polyp formation in apc+/- mice. (2010)
  • Author(s): Matsunaka T, Miyamoto S, Shitara K, Ochiai A, Chiba T.
  • Journal Title: Mol Cancer Ther. 9(2) Pages: 419-28
  • Peer Reviewed
• [Journal Article] Adenocarcinoma derived from Brunner's gland. (2010)
  • Author(s): Kitagori K, Miyamoto S, Sakurai T.
  • Journal Title: Clin Gastroenterol Hepatol 8(4)
  • Peer Reviewed
• [Journal Article] Ligand-specific antibodies to insulin-like growth factors suppress intestinal polyp formation in apc+/- mice. (2010)
  • Author(s): Matsunaka T, Miyamoto S, Shitara K, Ochiai A, Chiba T.
  • Journal Title: Mol.Cancer Ther. Volume: 9 Pages: 419-428
  • Peer Reviewed
• [Journal Article] Adenocarcinoma derived from Brunner's gland. (2010)
  • Author(s): Kitagori K, Miyamoto S, Sakurai T.
  • Journal Title: Clin Gastroenterol Hepatol Volume: 8
  • Peer Reviewed
• [Journal Article] Adenocarcinoma derived from Brunner's gland. (2010)
  • Author(s): Kitagori K, Miyamoto S, Sakurai T.
  • Journal Title: Clin Gastroenterol Hepatol. (in press)
  • Peer Reviewed
• [Journal Article] Multiple early-stage malignant melanoma of the esophagus with long follow-up period after endoscopic treatment : report of a case. (2009)
  • Author(s): Morita S, Miyamoto S, Matsumoto S, Muto M, Chiba T.
  • Journal Title: Esophagus 6(4) Pages: 249-252
  • Peer Reviewed
• [Journal Article] Barr Virus infection presenting as severe gastroenteritis without infectious mononucleosis-like manifestations. (2009)
  • Author(s): Fujiwara M, Miyamoto S, Iguchi K, Matsunaka T, Sakashita H, Tsuruyama T, Kanegane H, Marusawa H, Nakase H, Chiba1 T. Acute Epstein.
  • Journal Title: Clin J Gastroenterol 2 Pages: 398-403
  • Peer Reviewed
• [Journal Article] Involvement of Lupus Enteritis in a Patient with Lupus Cystitis and Nephritis. (2009)
  • Author(s): Akitake R, Nakase H, Ueno S, Miyamoto S, Iehara N, Chiba T.
  • Journal Title: Digestion 80 Pages: 160-164
  • Peer Reviewed
• [Journal Article] Multiple early-stage malignant melanoma of the esophagus with long follow-up period after endoscopic treatment : report of a case. (2009)
  • Author(s): Morita S, Miyamoto S, Matsumoto S, Muto M, Chiba T.
  • Journal Title: Esophagus 6 Pages: 249-252
  • Peer Reviewed
• [Journal Article] Acute Epstrin-Barr Virus infection presenting as severe gastroenteritis without infectious mononucleosis-like manifestations. (2009)
  • Author(s): Fujiwara M, Miyamoto S, Iguchi K, Matsunaka T, Sakashita H, Tsuruyama T, Kanegane H, Marusawa H, Nakase H, Chiba T.
  • Journal Title: Clin J Gastroenterol 2 Pages: 398-403
  • Peer Reviewed
• [Journal Article] Roles of osteoclasts and bone-derived IGFs in the survival and growth of human breast cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice. (2008)
  • Author(s): Sangai T, Fujimoto H, Miyamoto S, Maeda H, Nakamura M, Ishii G, Nagai K, Nagashima T, Miyazaki M, Ochiai A.
  • Journal Title: Clin Exp Metastasis. 25(4) Pages: 401-10
  • Peer Reviewed
• [Journal Article] Pancreatic Somatostatinoma With von Recklinghausen's Disease. (2008)
  • Author(s): Takai A, Setoyama T, Miyamoto S.
  • Journal Title: Clin Gastroenterol Hepatol. (in press)
  • Peer Reviewed
• [Presentation] Poster Session Tumor Biology 6 : Targets in the Microenvironment Ligand-specific antibody to insulin-like growth factors suppresses the intestinal polyp formation in APC+/- mouse. (2009)
  • Author(s): 宮本心一, et. al.
  • Organizer: 100^<th> American Association for Cancer Research (AACR)
  • Place of Presentation: Denver, Colorado, USA.
  • Year and Date: 2009-04-19
• [Presentation] Ligand-specific antibody to insulin-like growth factors suppresses the intestinal polyp formation in APC+/-mouse (2009)
  • Author(s): Shin'ichi Miyamoto
  • Organizer: 100^<th> American Association for Cancer Research (AACR)
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 2009-04-18
• [Presentation] Ligand-specific antibody to insulin-like growth factors suppresses the intestinal polyp formation in APC+/- mouse. IGF中和抗体は、APC+/-マウスにおけるポリープ形成を抑制する。 (2008)
  • Author(s): 松中寿浩、宮本心一, 他.
  • Organizer: 第67回日本癌学会総会・ワークショップ
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] Ligand-specific Antibodies to Insulin-like Growth Factors Suppress the Intestinal Polyp Formation in APC+/-Mouse. (2008)
  • Author(s): 松中寿浩
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-10-30
• [Remarks] ホームページ等
  • URL: http://www.kuhp.kyoto-u.ac.jp/~gastro/mmuto/