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Involvement of interstitial cells of Cajal in gut movement, especially in type2 diabetes mellitus.

Research Project

Project/Area Number 20590741
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionOsaka University

Principal Investigator

TSUTSUI Shusaku  Osaka University, 医学系研究科, 助教 (10359846)

Co-Investigator(Kenkyū-buntansha) WATABE Kenji  大阪大学, 医学系研究科, 助教 (50379244)
KISO Shinnichi  大阪大学, 医学系研究科, 助教 (40335352)
YOSHIDA Yuichi  大阪大学, 医学系研究科, 助教 (30457014)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsカハール介在細胞 / 消化管運動 / 糖尿病 / IGF-1 / KIT / db/dbマウス / db / dbマウス / 消化管運動障害 / 2型糖尿病
Research Abstract

Recently, interstitial cells of Cajal (ICC) are recognized as one of fundamental factors that regulates gut movement.
1) We first analyzed db/db mice as a model of type 2 diabetes mellitus and found that gut movement was disturbed and the area of ICC was decreased in stomach, small intestine and colon in these mice. The results suggest that ICC may be involved in the disturbed gut motility in type 2 diabetes mellitus.
2) We then attempted to reduce damage in ICC in db/db mice pharmacologically. Because IGF-1 was reported to support the survival of ICC in tissue culture, we started the delivery of IGF-1 continuously into db/db mice before the onset of diabetes and continued its infusion for 7 weeks. However, the area of ICC was comparable to control mice (saline infusion). The method to reduce damage in ICC remains to be solved.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (21 results)

All 2011 2010 2009 2008

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (1 results)

  • [Journal Article] Short-term outcomes of endoscopic submucosal dissection (ESD) for early gastric neoplasm : multicenter survey by osaka university ESD study group.2011

    • Author(s)
      Akasaka T, Tsutsui S, et al.
    • Journal Title

      Dig Endosc.

      Volume: Jan(23) Pages: 73-77

    • NAID

      10031163751

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic submucosal dissection as a treatment for gastric noninvasive neoplasia : a multicenter study by Osaka University ESD Study Group.2010

    • Author(s)
      Kato M, Tsutsui S, et al.
    • Journal Title

      J.Gastroenterol

      Volume: Nov 25(Published online)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lack of adiponectin promotes formation of cholesterol gallstones in mice.2010

    • Author(s)
      Ogiyama H, Tsutsui S, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: Aug 27 Pages: 352-358

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I trial of gemcitabine dose escalation with concurrent radiotherapy for patients with locally advanced pancreatic cancer.2010

    • Author(s)
      Nishida T, Tsutsui S, et al.
    • Journal Title

      Pancreatology

      Volume: 10(1) Pages: 60-65

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of double-balloon endoscopy in the diagnosis and treatment of Crohn's disease : a multicenter experience.2010

    • Author(s)
      Kondo J, Tsutsui S, et al.
    • Journal Title

      J.Gastroenterol.

      Volume: Jul45(7) Pages: 713-720

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice.2010

    • Author(s)
      Yamada T, Tsutsui S, et al.
    • Journal Title

      J.Gastroenterol.

      Volume: Jul45(7) Pages: 742-749

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Esophageal intramural pseudodiverticulosis : a rare cause of esophageal stricture.2010

    • Author(s)
      Yamamoto S, Tsutsui S, et al.
    • Journal Title

      Clin Gastroenterol Hepatol.

      Volume: Jul8(7)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A patient who developed diaphragmatic hernia 20 months after percutaneous radiofrequency ablation for hepatocellular carcinoma2010

    • Author(s)
      Nawa T, Tsutsui S, et al.
    • Journal Title

      Nipponn Shokakibyo Gakkai Zasshi

      Volume: Jul,107(7) Pages: 1167-1174

    • NAID

      10026530296

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of double-balloon endoscopy in the diagnosis and treatment of Crohn's disease : a multicenter experience2010

    • Author(s)
      Kondo j, Tsutsui S, et al.
    • Journal Title

      J Gastroenterol Feb 20

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice2010

    • Author(s)
      Yamada T, Tsutsui S, et al.
    • Journal Title

      J Gastroenterol Feb 13

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Restoration of gut motility in Kit-deficient mice by bone marrow transplantation.2009

    • Author(s)
      Ishii S, Tsuji S, Tsujii M, Nishida T, Watabe K, et. al.
    • Journal Title

      J Gastro 44(8)

      Pages: 834-41

    • NAID

      10025176591

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel therapeutic strategy with anti-CD9 antibody in gastric cancers2009

    • Author(s)
      Nakamoto T, Tsutsui S, et al.
    • Journal Title

      J Gastroenterol 44(9)

      Pages: 889-96

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salvage cystic duct anastomosis using a magnetic compression technique for incomplete bile duct reconstruction in living donor liver transplantation2009

    • Author(s)
      Maruhashi S, Tsutsui S, et al.
    • Journal Title

      Liver Transpl 16(1)

      Pages: 33-37

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization2009

    • Author(s)
      Fukushima J, Tsutsui S, et al.
    • Journal Title

      Hepatol Res 39(7)

      Pages: 724-38

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visceral obesity and hypoadiponectinemia are significant determinants of hepatic dysfunction : An epidemiologic study of 3827 Japanese subjects2009

    • Author(s)
      Kamada Y, Yoshida Y, et al.
    • Journal Title

      J Clin Gastroenterol 43(10)

      Pages: 995-1000

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice2009

    • Author(s)
      Kamada Y, Kiso S, et al.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 296(2)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice.2009

    • Author(s)
      Kamada Y, Yoshida Y, etal
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 296

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delayed liver regeneration after partial hepatectomy inadiponectin knockout mice.2009

    • Author(s)
      Ezaki H, Yoshida Y, et al
    • Journal Title

      Biochem Biophys Res Commun. 378

      Pages: 68-72

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disturbed gastrointestinal motility and decreased interstitial cells of Cajal in diabetic db/db mice.2008

    • Author(s)
      Yamamoto T, Watabe K, Nakahara M, Ogiyama H, Kiyohara T, Tsutsui S, et. al.
    • Journal Title

      J Gastroenterol Hepatol 23(4)

      Pages: 660-667

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disturbed gastrointestinal motility and decreased interstitial cells of Cajal in diabetic db/db mice.2008

    • Author(s)
      Yamamoto T, Watabe K, et al
    • Journal Title

      J Gastroenterol Hepatol. 23

      Pages: 660-667

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Adipose tissue derived stromal ce11(ADSC)を用いた肝再生療法開発へ向けた検討2008

    • Author(s)
      鎌田佳宏, 木曽真一, など
    • Organizer
      JDDW 2008
    • Place of Presentation
      JDDW 2008
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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