Involvement of interstitial cells of Cajal in gut movement, especially in type2 diabetes mellitus.
| Project/Area Number |
20590741
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
TSUTSUI Shusaku Osaka University, 医学系研究科, 助教 (10359846)
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| Co-Investigator(Kenkyū-buntansha) |
WATABE Kenji 大阪大学, 医学系研究科, 助教 (50379244)
KISO Shinnichi 大阪大学, 医学系研究科, 助教 (40335352)
YOSHIDA Yuichi 大阪大学, 医学系研究科, 助教 (30457014)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | カハール介在細胞 / 消化管運動 / 糖尿病 / IGF-1 / KIT / db/dbマウス / db / dbマウス / 消化管運動障害 / 2型糖尿病 |
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| Research Abstract |
Recently, interstitial cells of Cajal (ICC) are recognized as one of fundamental factors that regulates gut movement.
1) We first analyzed db/db mice as a model of type 2 diabetes mellitus and found that gut movement was disturbed and the area of ICC was decreased in stomach, small intestine and colon in these mice. The results suggest that ICC may be involved in the disturbed gut motility in type 2 diabetes mellitus.
2) We then attempted to reduce damage in ICC in db/db mice pharmacologically. Because IGF-1 was reported to support the survival of ICC in tissue culture, we started the delivery of IGF-1 continuously into db/db mice before the onset of diabetes and continued its infusion for 7 weeks. However, the area of ICC was comparable to control mice (saline infusion). The method to reduce damage in ICC remains to be solved.
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Report
(4 results)
Research Products
(21 results)
