| Project/Area Number |
20590744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKAMURA Shotaro Kyushu University, 大学病院, 助教 (10243932)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Takayuki 九州大学, 大学病院, 講師 (10278955)
IIDA Mitsuo 九州大学, 大学院・医学研究院, 教授 (00127961)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 消化管リンパ腫 / 濾胞性リンパ腫 / FISH / 染色体転座 / BCL2 / IGH / MALTリンパ腫 / DLBCL / トリソミー / MALT1 |
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| Research Abstract |
Background : Chromosomal translocation t(14;18)(q32;q21)/IGH-BCL2 is found in 60-90% of nodal follicular lymphomas (FL). The prevalence and clinical significance of the translocation have not been examined in gastrointestinal FL. Methods & Results : Clinicopathologic and molecular features were investigated in 48 patients with gastrointestinal FL. The site of involvement was the duodenum (54%), the jejunum (52%), the ileum (52%), the stomach (29%), and the colorectum (15%). t(14;18) was detected in 39 (81%) cases by the interphase fluorescence in situ hybridization. The involvement of multiple sites (69% vs. 0%), a manifestation of lymphomatous polyposis type (72% vs. 22%) and a histological grade of 1 or 2 (92% vs. 56%) were more frequent in the t(14;18)-positive group than in the negative group. In addition, the rate of complete remission was lower in the t(14;18)-positive group than in the negative group (56% vs. 100%, P=0.018) with a trend towards poorer event-free survival in the former group (P=0.089). Conclusions : t(14;18)/IGH-BCL2 occurs frequently in gastrointestinal follicular lymphomas. This translocation may be a predictor for the adverse clinical course.
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