| Project/Area Number |
20590745
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
|---|
| Research Institution | Saga University |
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Principal Investigator |
RYUICHI Iwakiri Saga University, 医学部, 准教授 (70232642)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TODA Shuji 佐賀大学, 医学部, 教授 (80188755)
TSUNADA Seiji 佐賀大学, 医学部, 助教 (70264158)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 大腸癌 / 脂肪摂取 / 脂肪酸 / Wnt signaling / 酸化ストレス / 共役脂肪酸 / Wntシグナル / アラキドン酸カスケード / 共役リノール酸 / 発癌抑制 / アポトーシス / COX-2 / 飽和脂肪酸 / 細胞増殖 |
|---|
| Research Abstract |
We investigated whether various dietary fats affected the colon mucosal growth and tumorigenesis in azoxymethane-treated rats. Rats were supplemented with 10% corn, olive, beef, and fish oil for 44 weeks. Long-term dietary corn oil and beef tallow increased tumor incidence with increased BrdU incorporation. In contrast, both olive and fish oil inhibited them. BrdU-incorporated cells were often observed at tops of crypts in rats fed with beef tallow. Long-term high intake of corn oil and beef tallow enhanced cell proliferation and modulated distribution of proliferating cells, which might contribute to promoting effect in colon tumorigenesis.
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