Role of REG protein in the regeneration and carcinogenesis of colorectal epithelial cells

• Project/Area Number: 20590747
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Dokkyo Medical University
• Principal Investigator: FUKUI Hirokazu Dokkyo Medical University, 医学部, 講師 (60378742)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 遺伝子 / 癌 / 再生医学 / 病理学 / 臨床

Research Abstract

REG protein is induced by Interleukins 6 and 22 stimulations in colitis tissues. REG protein has an anti-apoptotic effect on colonic epithelial cells and its effect may play a role in the development of inflammation-related cancers. REG protein is overexpressed in the dysplastic lesion in ulcerative colitis tissues, and therefore, its detection may be an useful tool to not only diagnose but also predict ulcerative colitis-related neoplastic lesions.

Research Products

• [Journal Article] Immunohistochemical analysis of REG I expression in ulcerative colitis-associated neoplastic lesions. (2011)
  • Author(s): Tanaka H, Fukui H, Fujii S, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, Imura J, Yasuda Y, Chiba T, Fujimori T
  • Journal Title: Digestion 83 Pages: 204-209
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of REG Iα expression in ulcerative colitis-associated neoplastic lesions (2011)
  • Author(s): Tanaka H
  • Journal Title: Digestion Volume: 83 Pages: 204-209
  • Peer Reviewed
• [Journal Article] GRO promotes invasion of colorectal cancer cells. (2010)
  • Author(s): Ogata H, Sekikawa A, Fukui H
  • Journal Title: Oncol Rep 24 Pages: 1479-1486
  • Peer Reviewed
• [Journal Article] Expression of -catenin and REG I in relation to cell proliferative ability in salivary gland tumors. (2010)
  • Author(s): Hakata Y, Fukui H, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, Imura J, Kawamata H, Imai Y, Fujimori T
  • Journal Title: Exp Ther Med 1 Pages: 437-443
  • Peer Reviewed
• [Journal Article] Involvement of the IL-22/REG I axis in ulcerative colitis. (2010)
  • Author(s): Sekikawa A, Fukui H, Suzuki K, Karibe T,Fujii S, Ichikawa K, Tomita S, Imura J, Shiratori K, Chiba T, Fujimori T
  • Journal Title: Lab Invest 90 Pages: 496-505
  • Peer Reviewed
• [Journal Article] Involvement of the IL-22/REG Iα axis in ulcerative colitis (2010)
  • Author(s): Sekikawa A
  • Journal Title: Lab Invest Volume: 90 Pages: 496-505
  • Peer Reviewed
• [Journal Article] Expression of β-catenin and REG Iα in relation to cell proliferative ability in salivary gland tumors (2010)
  • Author(s): Hakata Y
  • Journal Title: Exp Ther Med Volume: 1 Pages: 437-443
  • Peer Reviewed
• [Journal Article] GROα promotes invasion of colorectal cancer cells (2010)
  • Author(s): Ogata H
  • Journal Title: Oncol Rep Volume: 24 Pages: 1479-1486
  • Peer Reviewed
• [Journal Article] Expression profile of REG family proteins, REG I and REG IV in advanced gastric cancer : Comparison with mucin phenotype and prognostic markers. (2009)
  • Author(s): Yamagishi H, Fukui H, Sekikawa A
  • Journal Title: Modern Pathol 22 Pages: 906-13
  • Peer Reviewed
• [Journal Article] Involvement of REG I protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjogren's syndrome. (2009)
  • Author(s): Kimura T, Fukui H, Sekikawa A
  • Journal Title: Clin Exp Immunol 155 Pages: 16-20
  • Peer Reviewed
• [Journal Article] Role of Necl-5 in the Pathophysiology of colorectal lesions induced by dimethylhydrazine and/or dextran sodium sulfate. (2009)
  • Author(s): Abe A, Fukui H, Fujimori T
  • Journal Title: J Pathol 217 Pages: 42-53
  • Peer Reviewed
• [Journal Article] Role of Necl-5 in the Pathophysiology of colorectal lesions induced dimethylhydrazine and/or dextran sodium sulfate (2009)
  • Author(s): Abe A
  • Journal Title: J Pathol 217 Pages: 42-53
  • Peer Reviewed
• [Journal Article] Involvement of REG Iα protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjogren's syndrome (2009)
  • Author(s): Kimura T
  • Journal Title: Clin Exp Immunol 155 Pages: 16-20
  • Peer Reviewed
• [Journal Article] Expression profile of REG family proteins, REG Iα and REG IV in advanced gastric cancer (2009)
  • Author(s): Yamagishi H
  • Journal Title: Modern Pathol 22 Pages: 906-913
  • Peer Reviewed
• [Journal Article] EXTL3 promoter methylation down-regulates EXTL3 and heparan sulphate expression in mucinous colorectal cancers. (2008)
  • Author(s): Karibe T, Fukui H, Sekikawa A, Shiratori K, Fujimori T
  • Journal Title: J Pathol 216 Pages: 32-42
  • Peer Reviewed
• [Journal Article] Inhibitory effects of the cyclooxygenase-2 inhibitor, etodolac, on colitis-associated tumorigenesis in p53-deficient mice treated with dextran sulfate sodium. (2008)
  • Author(s): Mukawa K, Fukui H, Fujimori T
  • Journal Title: Oncol Rep 19 Pages: 393-399
  • Peer Reviewed
• [Journal Article] Expression of SDF-1 and nuclear CX predict lymph node metastasis in colorectal cancer. (2008)
  • Author(s): Yoshitake N, Fukui H, Yamagishi H, Sekikawa A, Fujii S, Tomita S, Ichikawa K, Imura J, Hiraishi H, Fujimori T
  • Journal Title: Br J Cancer 98 Pages: 1682-1689
  • Peer Reviewed
• [Journal Article] REG I protein me anti-apoptotic effect of STAT3 signaling in gastric cancer cells. (2008)
  • Author(s): Sekikawa A, Fukui H, Fujii S, Ichikawa K, Tomita S, Imura J, Chiba T, Fujimori T
  • Journal Title: Carcinogenesis 29 Pages: 76-83
  • Peer Reviewed
• [Journal Article] Depth of tumor invasion in locally advanced rectal cancer correlates with the patients' prognosis (2008)
  • Author(s): Katsumata D
  • Journal Title: Surgery Today 38 Pages: 115-122
  • Peer Reviewed
• [Journal Article] REG Ia protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells (2008)
  • Author(s): Sekikawa A
  • Journal Title: Carcinogenesis 29 Pages: 76-83
  • Peer Reviewed
• [Journal Article] Expression of SDF-la and nuclear CXCR4 predict lymph node metastasis in colorectal cancer (2008)
  • Author(s): Yoshitake N
  • Journal Title: Br J Cancer 98 Pages: 1682-1689
  • Peer Reviewed
• [Journal Article] EXTL3 promoter methylation down-regulates EXTL3 and heparan sulphate expression in mucinous colorectal cancers (2008)
  • Author(s): Karibe T
  • Journal Title: J Pathol 216 Pages: 32-42
  • Peer Reviewed
• [Journal Article] The CD155/poliovirus receptor enhances the proliferation of ras-mutated cells (2008)
  • Author(s): Kono T
  • Journal Title: Int Cancer 122 Pages: 317-324
  • Peer Reviewed
• [Journal Article] Inhibitory effects of the cyclooxygenase-2 inhibitor, etodolac, on colitis-associated tumorigenesis in p53-deficient mice treated with dextran sulfate sodium (2008)
  • Author(s): Mukawa K
  • Journal Title: Oncol Rep 19 Pages: 393-399
  • Peer Reviewed
• [Presentation] 潰瘍性大腸炎関連腫瘍におけるREG I発現の意義 (2010)
  • Author(s): 福井広一
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-27
• [Presentation] 潰瘍性大腸炎関連腫瘍におけるREG Iα発現の意義 (2010)
  • Author(s): 福井広一
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-27
• [Presentation] 大腸粘液癌におけるヘパラン硫酸発現とEXTL3プロモーターメチレーションの関連について (2009)
  • Author(s): 福井広一
  • Organizer: Japan DDW 2009 第51回日本消化器病学会大会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] 潰瘍性大腸炎粘膜におけるインターロイキン22およびREG Iαの発現について (2009)
  • Author(s): 福井広一
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] 潰瘍性大腸炎粘膜におけるインターロイキン22おまびREG Iαの発現について (2009)
  • Author(s): 福井広一
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] EXTL3 promoter methylation is involved in the reduction of heparan sulfate expression in mucinous colorectal cancers (2008)
  • Author(s): 福井広一
  • Organizer: 日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] REG Iα gene expression is inducible by IL-6-STAT3 signal pathway in H. pylori-induced gastritis (2008)
  • Author(s): Fukui H
  • Organizer: 7th China-Korea-Japan Joint Conference on Helicobacter Infection
  • Place of Presentation: Kyoto
  • Year and Date: 2008-02-22