Establishment of cancer surveillance using serum anti-p53 antibody in patients with ulcerative colitis

• Project/Area Number: 20590748
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: IWAO Yasushi Keio University, 医学部, 講師 (40168547)
• Co-Investigator(Kenkyū-buntansha): HIBI Toshifumi 慶應義塾大学, 医学部, 教授 (50129623)
• Co-Investigator(Renkei-kenkyūsha): INOUE Nagamu 慶應義塾大学, 医学部, 講師 (00232546)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 潰瘍性大腸炎 / 大腸癌 / サーベイランス / ELISA / p53 / dysplasia / 内神鏡 / 早期発見 / 清瘍性大腸炎 / 内視鏡

Research Abstract

Here we evaluated clinical usefulness of the measurement of anti-p53 antibodies (Abs) by enzyme-linked immunosorbent assay (ELISA) using sera samples from ulcerative colitis (UC) patients. Serum p53 Ab was positive in 15.0% of UC, while it was positive only in 1.6% of HCs. Eight of 13 (61.5%) UC patients with CRC or dysplasia were positive for serum p53 Abs. This study revealed that p53 Ab developed in the progression of UC-associated CRC but not in all patients with neoplasia, suggesting that it is helpful in salvaging patients who drop from a surveillance program.

Research Products

• [Journal Article] Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis. (2011)
  • Author(s): Kawamata S, Matsuzaki K, Murata M, Seki T, Matsuoka K, Iwao Y, Hibi T, Okazaki K
  • Journal Title: Inflamm Bowel Dis 17(3) Pages: 683-95
  • Peer Reviewed
• [Journal Article] Target biopsy or step biopsy? Optimal surveillance for ulcerative colitis : a Japanese nationwide randomized controlled trial. (2011)
  • Author(s): Watanabe T, Ajioka Y, Matsumoto T, Tomotsugu N, Takebayashi T, Inoue E, Iizuka B, Igarashi M, Iwao Y, Ohtsuka K, Kudo SE, Kobayashi K, Sada M, Matsumoto T, Hirata I, Murakami K, Nagahori M, Watanabe K, Hida N, Ueno F, Tanaka S, Watanabe M, Hibi T
  • Journal Title: J Gastroenterol 46Suppl 1 Pages: 11-6
  • NAID: 10029029994
  • Peer Reviewed
• [Journal Article] Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis. (2011)
  • Author(s): Kawamata S, Iwao Y, et al
  • Journal Title: Inflamm Bowel Dis Volume: 17 Pages: 683-695
  • Peer Reviewed
• [Journal Article] Target biopsy or step biopsy? Optimal surveillance for ulcerative colitis : a Japanese nationwide randomized controlled trial. (2011)
  • Author(s): Watanabe T, Iwao Y, et al
  • Journal Title: J Gastroenterol Volume: 46
  • NAID: 10029029994
  • Peer Reviewed
• [Journal Article] Rapid endoscopic improvement is important for 1-year avoidance of colectomy but not for the long-term prognosis in cyclosporine A treatment for ulcerative colitis. (2010)
  • Author(s): Kobayashi T, Naganuma M, Okamoto S, Hisamatsu T, Inoue N, Ichikawa H, Takayama T, Saito R, Sujino T, Ogata H, Iwao Y, Hibi T
  • Journal Title: J Gastroenterol 45(11) Pages: 1129-37
  • NAID: 10027699761
  • Peer Reviewed
• [Journal Article] Novel endoscopic activity index is useful for choosing treatment in severe active ulcerative colitis patients. (2010)
  • Author(s): Naganuma M, Ichikawa H, Inoue N, Kobayashi T, Okamoto S, Hisamatsu T, Kanai T, Ogata H, Iwao Y, Hibi T
  • Journal Title: J Gastroenterol 45(9) Pages: 936-43
  • NAID: 10027698991
  • Peer Reviewed
• [Journal Article] Novel endoscopic activity index is useful for choosing treatment in severe active ulcerative colitis patients. (2010)
  • Author(s): Naganuma M, Iwao Y, et al
  • Journal Title: J Gastroenterol Volume: 45 Pages: 936-943
  • NAID: 10027698991
  • Peer Reviewed
• [Journal Article] Novel endoscopic activity index is useful for choosing treatment in severe activeulcerative colitis patients (2010)
  • Author(s): Naganuma M, Iwao Y, et al
  • Journal Title: J Gastroenterol (in press)
  • Peer Reviewed
• [Journal Article] Endoscopic and chromoendoscopic atlas featuring dysplastic lesions in surveillance colonoscopy for patients with long-standing ulcerative colitis. (2008)
  • Author(s): Matsumoto T, Iwao Y, Igarashi M, Watanabe K, Otsuka K, Watanabe T, Iizuka B, Hida N, Sada M, Chiba T, Kudo SE, Oshitani N, Nagawa H, Ajioka Y, Hibi T
  • Journal Title: Inflamm Bowel Dis 14(2) Pages: 259-64
  • Peer Reviewed
• [Journal Article] Lower doses of 6-mercaptopurine/azathioprine bring enough clinical efficacy and therapeutic concentration of erythrocyte 6-mercaptopurine metabolite in Japanese IBD patients. (2008)
  • Author(s): Komiyama T, Yajima T, Kubota R, Iwao Y, Sakuraba A, Funakoshi S, Negishi K, Minami I, Tanaka Y, Mae H, Hibi T
  • Journal Title: J Crohns Colitis 2(4) Pages: 315-21
  • Peer Reviewed
• [Journal Article] A pilot open-labeled prospective randomized study between weekly and intensive treatment of granulocyte and monocyte adsorption apheresis for active ulcerative colitis. (2008)
  • Author(s): Sakuraba A, Twao Y, et al
  • Journal Title: J Gastroenterol 43 Pages: 51-56
  • Peer Reviewed
• [Journal Article] Endoscopic and chromoendoscopic atlas featuring dysplastic lesions in surveillance colonoscopy for patients with long-standing ulcerative colitis. (2008)
  • Author(s): Matsumoto T, Twao Y, et al
  • Journal Title: Tnflamm Bowel Dis 14 Pages: 259-264
  • Peer Reviewed
• [Journal Article] Efficacy of infliximab for induction and maintenance of remission in intestinal behcet's disease. (2008)
  • Author(s): Naganuma M, Twao Y, et al
  • Journal Title: Tnflamm Bowel Dis 14 Pages: 1259-1264
  • Peer Reviewed
• [Presentation] 大腸腫瘍性病変に対するESDの工夫 (2010)
  • Author(s): 今枝博之、細江直樹、中溝裕雅、別所理恵子、齋藤理子、小池祐司、井上詠、石井良幸、長谷川博俊、岩男泰、緒方晴彦、北川雄光、日比紀文
  • Organizer: 第79回日本消化器内視鏡学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-15
• [Presentation] 早期大腸癌の内視鏡摘除後における大腸内視鏡サーベイランスの検討 (2009)
  • Author(s): 井田陽介、今枝博之、細江直樹、中溝裕雅、別所理恵子、斉藤理子、小池祐司、井上詠、長谷川博俊、岩男泰、緒方晴彦、杉野吉則、北川雄光、日比紀文
  • Organizer: 第27回日本大腸検査学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-28