Development of a biomarker for inflammatory bowel disease by plasma amino acids profile.

• Project/Area Number: 20590749
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: HISAMATSU Tadakazu Keio University, 医学部, 講師 (60255437)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 炎症性腸疾患 / アミノ酸 / ヒスチジン / 炎症性サイトカイン / マクロファージ / アミノインデックス[○!R] / メタボローム / アミノインデックスR / アミノインデックス

Research Abstract

Amino acids in Elental[○!R] directly suppress intestinal inflammation in IL-10 transfer colitis models. Especially, L-histidine suppressed NFkB activation and significantly inhibited the production of pro-inflammatory cytokines by macrophages. In human IBD, plasma amino acids profiles were dramatically changed. Plasma histidine concentration was decreased in active IBD patients and showed inverted correlation with serum CRP. Furthermore, the computer analysis of plasma amino acids profiles developed the AminoIndex[○!R] that is a parameter for diagnosis and assessment of disease activity in IBD.

Research Products

• [Journal Article] Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages. (2011)
  • Author(s): Naruse H, Hisamatsu T, Yamauchi Y, Chang JE, Matsuoka K, Kitazume MT, Arai K, Ando S, Kanai T, Kamada N, Hibi T.
  • Journal Title: Clin Exp Immunol. 164(1) Pages: 137-44
  • Peer Reviewed
• [Journal Article] Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages. 2011 Feb 24. (2011)
  • Author(s): Naruse H, Hisamatsu T, Yamauchi Y, Chang JE, Matsuoka K, Kitazume MT, Arai K, Ando S, Kanai T, Kamada N, Hibi T.
  • Journal Title: Clin Exp Immunol. Volume: Feb 24.
  • Peer Reviewed
• [Journal Article] Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease. (2010)
  • Author(s): Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, Matuzaki Y, Suzuki S, Sugita A, Koganei K, Hisamatsu T, Kanai T, Hibi T.
  • Journal Title: Gastroenterology. 139(3) Pages: 882-92
  • Peer Reviewed
• [Journal Article] Monocyte Chemoattractant Protein-1 Contributes to Gut Homeostasis and Intestinal Inflammation by Composition of IL-10-Producing Regulatory Macrophage Subset. (2010)
  • Author(s): Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T.
  • Journal Title: J Immunol. 184(5) Pages: 2671-6
  • Peer Reviewed
• [Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease. (2010)
  • Author(s): Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
  • Journal Title: Inflamm Bowel Dis. 16(4) Pages: 568-75
  • Peer Reviewed
• [Journal Article] 血漿アミノ酸プロファイルを用いたIBDの診断 (2010)
  • Author(s): 久松理一、日比紀文
  • Journal Title: IBD Research vol.4 no.4 Pages: 308-313
• [Journal Article] アミノ酸と免疫Functinal Food (2010)
  • Author(s): 久松理一、日比紀文
  • Journal Title: 特集『免疫と機能性食品』2010第11号 Vol.4 No.1 Pages: 16-22
• [Journal Article] Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease. (2010)
  • Author(s): Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, Matuzaki Y, Suzuki S, Sugita A, Koganei K, Hisamatsu T, Kanai T, Hibi T.
  • Journal Title: Gastroenterology Volume: Sep;139(3) Pages: 882-892
  • Peer Reviewed
• [Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis. (2010)
  • Author(s): Mikami Y, Kanai T, Sujino T, Ono Y, Hayashi A, Okazawa A, Kamada N, Matsuoka K, Hisamatsu T, Okamoto S, Takaishi H, Inoue N, Ogata H, Hibi T.
  • Journal Title: Eur J Immunol. Volume: Sep;40(9) Pages: 2409-2422
  • Peer Reviewed
• [Journal Article] Monocyte Chemoattractant Protein-1 Contributes to Gut Homeostasis and Intestinal Inflammation by Composition of IL-10-Producing Regulatory Macrophage Subset. (2010)
  • Author(s): Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T
  • Journal Title: J Immunol. Volume: Mar 1;184(5) Pages: 2671-2676
  • Peer Reviewed
• [Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease. (2010)
  • Author(s): Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
  • Journal Title: Inflamm Bowel Dis. Volume: Apr;16(4) Pages: 568-575
  • Peer Reviewed
• [Journal Article] 血漿アミノ酸プロファイルを用いたIBDの診断 (2010)
  • Author(s): 久松理一、日比紀文
  • Journal Title: IBD Research(先端医学社) Volume: 12月号vol.4, no.4 Pages: 38-42
• [Journal Article] アミノ酸と免疫 (2010)
  • Author(s): 久松理一、日比紀文
  • Journal Title: Functinal Food Volume: 第11号Vol.4, No.1 Pages: 16-22
• [Journal Article] Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset (2010)
  • Author(s): Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T.
  • Journal Title: J Immunol 184(5): Pages: 2671-2676
  • Peer Reviewed
• [Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease (2010)
  • Author(s): Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
  • Journal Title: Inflamm Bowel Dis. 16(4) Pages: 568-575
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 久松理一, 日比紀文
  • Journal Title: 炎症性腸疾患と腸管局所免疫 Annual Review 消化器(中外医学社) Pages: 8-15
• [Journal Article] Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen presenting ability. (2009)
  • Author(s): Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Kitazume M, Takayama T, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
  • Journal Title: J Immunol. 183(3) Pages: 1724-31
  • Peer Reviewed
• [Journal Article] Dietary Histidine Ameliorates Murine Colitis by Inhibition of Proinflammatory Cytokine Production from Macrophages. (2009)
  • Author(s): Andou A, Hisamatsu T, Okamoto S, Chinen H, Kamada N, Kobayashi T, Hashimoto M, Okutsu T, Shimbo K, Takeda T, Matsumoto H, Sato A, Ohtsu H, Suzuki M, Hibi T.
  • Journal Title: Gastroenterology. 136(2) Pages: 564-74
  • Peer Reviewed
• [Journal Article] Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability (2009)
  • Author(s): Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Kitazume MT, Takayama T, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T
  • Journal Title: J Immunol. 183(3): Pages: 1724-1731
  • Peer Reviewed
• [Journal Article] Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells (2009)
  • Author(s): Wada Y, Hisamatsu T, Kamada N, Okamoto S, Hibi T.
  • Journal Title: Inflamm Bowel Dis. 15(10) Pages: 1548-1556
  • Peer Reviewed
• [Journal Article] Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages (2009)
  • Author(s): Andou A, Hisamatsu T, Okamoto S, Chinen H, Kamada N, Kobayashi T, Hashimoto M, Okutsu T, Shimbo K, Takeda T, Matsumoto H, Sato A, Ohtsu H, Suzuki M, Hibi T.
  • Journal Title: Gastroenterology 136(2): Pages: 564-574
  • Peer Reviewed
• [Journal Article] Pathogen-Specific Antibody : Cause or Effect? (2009)
  • Author(s): Hisamatsu T, Hibi T
  • Journal Title: Gastroenterology Nov;137(5) Pages: 1570-1573
• [Journal Article] Homeostatic(IL-7)and effector(IL-17)cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease (2009)
  • Author(s): Kanai T, Nemoto Y, Kamada N, Totsuka T, Hisamatsu T, Watanabe M, Hibi T.
  • Journal Title: Curr Opin Gastroenterol Jul;25(4) Pages: 306-313
• [Journal Article] (2009)
  • Author(s): 高山哲朗, 久松理一, 日比紀文
  • Journal Title: 【消化器疾患の分子医学 基礎医学から臨床へ】腸管免疫の分子機構臨床消化器内科 24巻2号(日本メディカルセンター) Pages: 217-223
• [Journal Article] (2009)
  • Author(s): 齊藤理子, 久松理一, 日比紀文
  • Journal Title: マクロファージからのIL-23産生と大腸炎、共生菌の関与臨床免疫・アレルギー科 52巻4号(科学評論社) Pages: 384-388
• [Journal Article] (2009)
  • Author(s): 久松理一, 日比紀文
  • Journal Title: Th-17細胞の機能はどこまで明らかになれたか?IBD Researoh vol.2 no.4(先端医学社) Pages: 308-313
• [Journal Article] (2009)
  • Author(s): 久松理一, 日比紀文
  • Journal Title: 腸管マクロファージとIBD IBD Research vol.3 no.3(先端医学社) Pages: 183-187
• [Journal Article] (2009)
  • Author(s): 久松理一
  • Journal Title: 日本人のヒット作品 ヒスチジンの経口投与がマクロファージからの炎症性サイトカインを抑えることでマウス腸炎を抑制する分子消化器病 vol.6, no.2(先端医学社) Pages: 83-85
• [Journal Article] Dietary Histidine Ameliorates Murine Colitis by Inhibition of Proinflammatory Cytokine Production from Macrophages. (2009)
  • Author(s): Andou A, Hisamatsu T, Okamoto S, Chinen H, Kamada N, Kobayashi T, Hashimoto M, Okutsu T, Shimbo K, Takeda T, Matsumoto H, Sato A, Ohtsu H, Suzuki M, Hibi T.
  • Journal Title: Gastroenterology 136(2) Pages: 564-574
  • Peer Reviewed
• [Journal Article] Retinoic acid contributes to the gut-specific immune tolerance via induction of IL-12-hypoproducing tolerogenic dendritic cells. (2009)
  • Author(s): Wada Y, Hisamatsu T, Kamada N, Okammoto S, Hibi T
  • Journal Title: Inflamm Bowel Dis. (in press)
  • Peer Reviewed
• [Journal Article] Unique CD14-positive intestinal macrophages contribute to the pathogenesis of Crohn's disease via IL-23/IFN-g axis (2008)
  • Author(s): Kamada N, Hisamatsu T, Okamoto S, Chinen H, Kobayashi T, Sato T, Sakuraba A, Kitazume M. T, Sugita A, Koganei K, Akagawa K. S, Toshifumi Hibi T.
  • Journal Title: J. Clin Invest 118(6) Pages: 2269-2280
  • Peer Reviewed
• [Journal Article] IL-23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. (2008)
  • Author(s): Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, Kitazume MT, Nakazawa A, Sugita A, Koganei K, Isobe KI, Hibi T
  • Journal Title: Gut 57(12) Pages: 1682-1689
  • Peer Reviewed
• [Journal Article] Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice. (2008)
  • Author(s): Ichikawa H, Okamoto S, Kamada N, Nagamoto H, Kitazume MT, Kobayashi T, Chinen H, Hisamatsu T, Hibi T.
  • Journal Title: Inflamm Bowel Dis. 14(11) Pages: 1483-1490
  • Peer Reviewed
• [Journal Article] Exacerbating role of gammadelta T cells in chronic colitis of T-cell receptor alpha mutant mice. (2008)
  • Author(s): Nanno M, Kanari Y, Naito T, Inoue N, Hisamatsu T, Chinen H, Sugimoto K, Shimomura Y, Yamagishi H, Shiohara T, Ueha S, Matsushima K, Suematsu M, Mizoguchi A, Hibi T, Bhan A K, Ishikawa H.
  • Journal Title: Gastroenterology 134(2) Pages: 481-490
  • Peer Reviewed
• [Journal Article] Nonpathogenic Escherichia coli strain Nissle 1917 inhibits signal trans duction in intestinal epithelial cells. (2008)
  • Author(s): Kamada N, Maeda K, Inoue N, Hisamatsu T, Okamoto S, Hong KS, Yamada T, Watanabe N, Tsuchimoto K, Ogata H, Hibi T.
  • Journal Title: Infect Immun. 76(1) Pages: 214-220
  • Peer Reviewed
• [Journal Article] Innate immunity in inflammatory bowel disease : state of the art. (2008)
  • Author(s): Hisamatsu T, Ogata H, Hibi T
  • Journal Title: Curr Opin Gastroenterol. 24(4) Pages: 448-454
  • Peer Reviewed
• [Journal Article] 炎症性腸疾患におけるアミノ酸補給の意義
  • Author(s): 久松理一、日比紀文
  • Journal Title: 日本消化吸収学会雑誌 Volume: (総説 in press)
  • NAID: 10029066191
  • Peer Reviewed
• [Presentation] 血漿アミノ酸プロファイルを用いた炎症性腸疾患の診断・活動性モニタリング (2010)
  • Author(s): 久松理一、井上 詠、松岡克善、斉藤理子、筋野智久、米野和明、三好潤、三上洋平、岩男泰、緒方晴彦、金井隆典、日比紀文、安藤朗、藤山佳秀、内山和彦、高木智久、内藤裕二、吉川敏一
  • Organizer: 難治性腸管障害調査研究班
  • Place of Presentation: 東京
  • Year and Date: 2010-07-30
• [Presentation] クローン病に対する成分栄養剤の作用機序-最新の知見を含めて- (2010)
  • Author(s): 久松理一
  • Organizer: 第7回肝・消化器代謝栄養研究会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2010-06-19
• [Presentation] クローン病に対する成分栄養剤の作用機序-最新の知見を含めて- (2010)
  • Author(s): 久松理一
  • Organizer: 第7回肝・消化器代謝栄養 研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-19
• [Presentation] 炎症性腸疾患をアミノ酸代謝から考える (2010)
  • Author(s): 久松理一、目比紀文
  • Organizer: 第8回日本機能性食品医用学会総会シンポジウムI 免疫と機能性食品
  • Place of Presentation: 大津 ピアザ淡海
• [Presentation] クローン病の腸管局所で何が起こっているか?ヒトサンプルを用いた研究から (2009)
  • Author(s): 久松理一
  • Organizer: 箱根山シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-09-15
• [Presentation] INTESTINAL MACROPHAGES AND NK CELLS PLAY A CRUCIAL ROLE FOR THE PATHOGENESIS OF CROHN'S DISEASE (2009)
  • Author(s): 久松理一, 日比紀文
  • Organizer: Industry Symposium, the 9th World Congress on Inflammation
  • Place of Presentation: Tokyo
  • Year and Date: 2009-07-09
• [Presentation] TL-1A and IL-23 from CD14+ macrophages synergistically enhanced production of IL-17 and IFN-γ by lamina propria CD4 memory T cells in Crohn's disease (2009)
  • Author(s): Hisamatsu T, Kamada N, Honda H, Kobayashi T, Okamoto S, Hibi T
  • Organizer: the 110th Annual Meeting of the AGA Institute
  • Place of Presentation: Chicago
  • Year and Date: 2009-06-02
• [Presentation] Bile acids contribute to the differentiation into anti-inflammatory DCs via Tgr5 and cAMP pathway (2009)
  • Author(s): Saito R, Hisamatsu T, Takayama T, Kamada N, Wada Y, Okamoto S, Hibi T
  • Organizer: the 110th Annual Meeting of the AGA Institute
  • Place of Presentation: Chicago
  • Year and Date: 2009-06-02
• [Presentation] アミノ酸が直接炎症を抑える (2009)
  • Author(s): 久松理一
  • Organizer: エレンタール講演会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2009-04-25
• [Presentation] アミノ酸が直接炎症を抑える (2009)
  • Author(s): 久松理一
  • Organizer: エレンタール講演会
  • Place of Presentation: 大阪
  • Year and Date: 2009-04-25
• [Presentation] アミノ酸が直接炎症を抑える (2009)
  • Author(s): 久松理一
  • Organizer: 第2回名古屋栄養セミナー
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2009-03-26
• [Presentation] CD4+Tlymphocytes with high CD26 surface expression are involved in the pathogenesis of inflammatory bowel disease (2009)
  • Author(s): Inoue N, Hisamatsu T, Takayama T, Kamada N, Okamoto S, Yamada T, Hosono O, Morimoto C, Hibi T
  • Organizer: 16th United European Gastroenterology Week
  • Place of Presentation: Austria
• [Presentation] Role of Lamina Propria Macrophages in the Regulation of Both Th1 and Th17 Immunity in Inflammatory Bowel Diseases (2009)
  • Author(s): Kamada N, Hisamatsu T, Kobayashi T, Okamoto S, Inoue N, Kanai T, Hibi T.
  • Organizer: 14th International Congress of Mucosal Immunology
  • Place of Presentation: Boston
• [Presentation] CD4+ T Lymphocytes with High CD26 Surface Expression are Involved in the Pathogenesis of inflammatory Bowel Disease (2009)
  • Author(s): Inoue N, Hisamatsu T, Takayama T, Kamada N, Hibi T
  • Organizer: 14th International Congress of Mucosal Immunology
  • Place of Presentation: Boston
• [Presentation] 自然免疫と消化器疾患 クローン病では腸管マクロファージと腸管NK細胞の interaction がIFNγ産生に関与する (2009)
  • Author(s): 久松理一, 高山哲朗, 日比紀文
  • Organizer: JDDW 2009
  • Place of Presentation: 京都
• [Presentation] ワークショップ1.「ヒト免疫病におけるTh17細胞とTreg細胞」ヒト免疫病における Th17細胞とTreg細胞 ヒト炎症性腸疾患において重要なのはTh1かTh17か? (2009)
  • Author(s): 久松理一, 日比紀文
  • Organizer: 日本臨床免疫学会総会
  • Place of Presentation: 東京
• [Presentation] シンポジウム1 消化器疾患と樹状細胞:病態の解明と治療法の開発 クローン病におけるCD14+腸管マクロファージの抗原提示能について (2009)
  • Author(s): 久松理一, 鎌田信彦, 本田治樹, 北爪美奈, 井上詠, 岡本晋, 金井隆典, 日比紀文
  • Organizer: 第46回日本消化器免疫学会総会
  • Place of Presentation: 愛媛
• [Presentation] 炎症性腸疾患(IBD)における血漿アミノ酸プロファイルを用いた臨床マーカー(アミノインデックス)の確立 (2009)
  • Author(s): 高山哲朗, 久松理一, 岡本晋, 高田康裕, 小林拓, 矢島知治, 長沼誠, 緒方晴彦, 岩男泰, 日比紀文
  • Organizer: 第106回 日本内科学会総会
  • Place of Presentation: 東京
• [Presentation] ベーチェット病における抗サイトカイン療法 (2008)
  • Author(s): 久松理一, 長沼誠, 日比紀文
  • Organizer: 第36回日本臨床免疫学会総会 ミニシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-10-17
• [Presentation] 自然免疫細胞と免疫疾患 (2008)
  • Author(s): 久松理一
  • Organizer: 第36回日本臨床免疫学会総会 ワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2008-10-17
• [Presentation] Pathogenesis of IBD : How much progress did we make? Roles of Macrophages in IBD : Pathogenic or Protective? (2008)
  • Author(s): Tadakazu Hisamatsu (invited speaker)
  • Organizer: The 3rd Japan-Korea IBD Symposium, Seoul
  • Place of Presentation: Korea
  • Year and Date: 2008-09-20
• [Presentation] 炎症性腸疾患におけるアミノ酸代紺モニタリングと誌断への応用 (2008)
  • Author(s): 久松理一, 安藤綾俊, 日比紀文
  • Organizer: JDDW 2008 パネルディスカッション
  • Place of Presentation: 東京
• [Presentation] MCP-1 依存性腸管マクロファージサブセットの腸管免疫恒常性における役割 (2008)
  • Author(s): 高田康裕, 久松理一, 鎌田信彦, 斉藤理子, 高山哲朗, 市川仁志, 小林拓, 知念寛, 井上詠, 岡本晋, 日比紀文
  • Organizer: 第45回日本消化器免疫学会
  • Place of Presentation: 京都
• [Presentation] クローン病における腸管マクロファージの腸内細菌認識異常-IL-23を中心とした慢性炎症サイクル- (2008)
  • Author(s): 久松理一, 鎌田信彦, 小林拓, 岡本晋, 井上詠, 緒方晴彦, 金井隆典, 日比紀文
  • Organizer: 第45回日本消化器免疫学会 シンポジウム
  • Place of Presentation: 京都
• [Book] Th-17細胞の機能はどこまで明らかになれたか? IBD Research vol. 2 no. 4 (2008)
  • Author(s): 久松理一, 日比紀文
  • Publisher: 先端医学社
• [Book] タンパク質・アミノ酸代謝と腸管免疫の関わり合い『栄養一評価と治療』25巻1号 (2008)
  • Author(s): 久松理一, 日比紀文
  • Publisher: メディカルレビュー社
• [Book] 特集「消化器疾患におけるアポトーシスを見直す」4)アポトーシスは炎症性腸疾患とどのようにかかわるか? 分子消化器病vol. 5 no. 2 (2008)
  • Author(s): 久松理一, 日比紀文
  • Publisher: 先端医学社
• [Book] 腸管免疫研究の最前線-腸管の恒常性維持と炎症性腸疾患におけるその破綻-Annual Review消化器2008 (2008)
  • Author(s): 久松理一, 鎌田信彦, 日比紀文
  • Publisher: 中外医学社
• [Remarks]
  • URL: http://web.sc.itc.keio.ac.jp/medicine/ibd/index.html
• [Remarks]
  • URL: http://web.sc.itc.keio.ac.jp/medicine/ibd/index.html
• [Remarks]
  • URL: http://web.sc.itc.keio.ac.jp/medicine/ibd/index.html