Development of a biomarker for inflammatory bowel disease by plasma amino acids profile.
Project/Area Number |
20590749
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 炎症性腸疾患 / アミノ酸 / ヒスチジン / 炎症性サイトカイン / マクロファージ / アミノインデックス[○!R] / メタボローム / アミノインデックスR / アミノインデックス |
Research Abstract |
Amino acids in Elental[○!R] directly suppress intestinal inflammation in IL-10 transfer colitis models. Especially, L-histidine suppressed NFkB activation and significantly inhibited the production of pro-inflammatory cytokines by macrophages. In human IBD, plasma amino acids profiles were dramatically changed. Plasma histidine concentration was decreased in active IBD patients and showed inverted correlation with serum CRP. Furthermore, the computer analysis of plasma amino acids profiles developed the AminoIndex[○!R] that is a parameter for diagnosis and assessment of disease activity in IBD.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages.2011
Author(s)
Naruse H, Hisamatsu T, Yamauchi Y, Chang JE, Matsuoka K, Kitazume MT, Arai K, Ando S, Kanai T, Kamada N, Hibi T.
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Journal Title
Clin Exp Immunol. 164(1)
Pages: 137-44
Related Report
Peer Reviewed
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[Journal Article] Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages. 2011 Feb 24.2011
Author(s)
Naruse H, Hisamatsu T, Yamauchi Y, Chang JE, Matsuoka K, Kitazume MT, Arai K, Ando S, Kanai T, Kamada N, Hibi T.
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Journal Title
Clin Exp Immunol.
Volume: Feb 24.
Related Report
Peer Reviewed
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[Journal Article] Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.2010
Author(s)
Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, Matuzaki Y, Suzuki S, Sugita A, Koganei K, Hisamatsu T, Kanai T, Hibi T.
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Journal Title
Gastroenterology. 139(3)
Pages: 882-92
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Peer Reviewed
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[Journal Article] Monocyte Chemoattractant Protein-1 Contributes to Gut Homeostasis and Intestinal Inflammation by Composition of IL-10-Producing Regulatory Macrophage Subset.2010
Author(s)
Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T.
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Journal Title
J Immunol. 184(5)
Pages: 2671-6
Related Report
Peer Reviewed
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[Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.2010
Author(s)
Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
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Journal Title
Inflamm Bowel Dis. 16(4)
Pages: 568-75
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Peer Reviewed
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[Journal Article] Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.2010
Author(s)
Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, Matuzaki Y, Suzuki S, Sugita A, Koganei K, Hisamatsu T, Kanai T, Hibi T.
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Journal Title
Gastroenterology
Volume: Sep;139(3)
Pages: 882-892
Related Report
Peer Reviewed
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[Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.2010
Author(s)
Mikami Y, Kanai T, Sujino T, Ono Y, Hayashi A, Okazawa A, Kamada N, Matsuoka K, Hisamatsu T, Okamoto S, Takaishi H, Inoue N, Ogata H, Hibi T.
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Journal Title
Eur J Immunol.
Volume: Sep;40(9)
Pages: 2409-2422
Related Report
Peer Reviewed
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[Journal Article] Monocyte Chemoattractant Protein-1 Contributes to Gut Homeostasis and Intestinal Inflammation by Composition of IL-10-Producing Regulatory Macrophage Subset.2010
Author(s)
Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T
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Journal Title
J Immunol.
Volume: Mar 1;184(5)
Pages: 2671-2676
Related Report
Peer Reviewed
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[Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.2010
Author(s)
Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
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Journal Title
Inflamm Bowel Dis.
Volume: Apr;16(4)
Pages: 568-575
Related Report
Peer Reviewed
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[Journal Article] Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset2010
Author(s)
Takada Y, Hisamatsu T, Kamada N, Kitazume MT, Honda H, Oshima Y, Saito R, Takayama T, Kobayashi T, Chinen H, Mikami Y, Kanai T, Okamoto S, Hibi T.
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Journal Title
J Immunol 184(5):
Pages: 2671-2676
Related Report
Peer Reviewed
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[Journal Article] TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease2010
Author(s)
Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
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Journal Title
Inflamm Bowel Dis. 16(4)
Pages: 568-575
Related Report
Peer Reviewed
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[Journal Article]2010
Author(s)
久松理一, 日比紀文
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Journal Title
炎症性腸疾患と腸管局所免疫 Annual Review 消化器(中外医学社)
Pages: 8-15
Related Report
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[Journal Article] Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen presenting ability.2009
Author(s)
Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Kitazume M, Takayama T, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.
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Journal Title
J Immunol. 183(3)
Pages: 1724-31
Related Report
Peer Reviewed
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[Journal Article] Dietary Histidine Ameliorates Murine Colitis by Inhibition of Proinflammatory Cytokine Production from Macrophages.2009
Author(s)
Andou A, Hisamatsu T, Okamoto S, Chinen H, Kamada N, Kobayashi T, Hashimoto M, Okutsu T, Shimbo K, Takeda T, Matsumoto H, Sato A, Ohtsu H, Suzuki M, Hibi T.
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Journal Title
Gastroenterology. 136(2)
Pages: 564-74
Related Report
Peer Reviewed
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[Journal Article] Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability2009
Author(s)
Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Kitazume MT, Takayama T, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T
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Journal Title
J Immunol. 183(3):
Pages: 1724-1731
Related Report
Peer Reviewed
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[Journal Article] Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages2009
Author(s)
Andou A, Hisamatsu T, Okamoto S, Chinen H, Kamada N, Kobayashi T, Hashimoto M, Okutsu T, Shimbo K, Takeda T, Matsumoto H, Sato A, Ohtsu H, Suzuki M, Hibi T.
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Journal Title
Gastroenterology 136(2):
Pages: 564-574
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Peer Reviewed
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[Journal Article]2009
Author(s)
高山哲朗, 久松理一, 日比紀文
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Journal Title
【消化器疾患の分子医学 基礎医学から臨床へ】腸管免疫の分子機構臨床消化器内科 24巻2号(日本メディカルセンター)
Pages: 217-223
Related Report
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[Journal Article]2009
Author(s)
齊藤理子, 久松理一, 日比紀文
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Journal Title
マクロファージからのIL-23産生と大腸炎、共生菌の関与臨床免疫・アレルギー科 52巻4号(科学評論社)
Pages: 384-388
Related Report
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[Journal Article]2009
Author(s)
久松理一, 日比紀文
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Journal Title
Th-17細胞の機能はどこまで明らかになれたか?IBD Researoh vol.2 no.4(先端医学社)
Pages: 308-313
Related Report
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[Journal Article]2009
Author(s)
久松理一, 日比紀文
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Journal Title
腸管マクロファージとIBD IBD Research vol.3 no.3(先端医学社)
Pages: 183-187
Related Report
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[Journal Article]2009
Author(s)
久松理一
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Journal Title
日本人のヒット作品 ヒスチジンの経口投与がマクロファージからの炎症性サイトカインを抑えることでマウス腸炎を抑制する分子消化器病 vol.6, no.2(先端医学社)
Pages: 83-85
Related Report
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[Journal Article] Dietary Histidine Ameliorates Murine Colitis by Inhibition of Proinflammatory Cytokine Production from Macrophages.2009
Author(s)
Andou A, Hisamatsu T, Okamoto S, Chinen H, Kamada N, Kobayashi T, Hashimoto M, Okutsu T, Shimbo K, Takeda T, Matsumoto H, Sato A, Ohtsu H, Suzuki M, Hibi T.
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Journal Title
Gastroenterology 136(2)
Pages: 564-574
Related Report
Peer Reviewed
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[Journal Article] Unique CD14-positive intestinal macrophages contribute to the pathogenesis of Crohn's disease via IL-23/IFN-g axis2008
Author(s)
Kamada N, Hisamatsu T, Okamoto S, Chinen H, Kobayashi T, Sato T, Sakuraba A, Kitazume M. T, Sugita A, Koganei K, Akagawa K. S, Toshifumi Hibi T.
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Journal Title
J. Clin Invest 118(6)
Pages: 2269-2280
Related Report
Peer Reviewed
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[Journal Article] IL-23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease.2008
Author(s)
Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, Kitazume MT, Nakazawa A, Sugita A, Koganei K, Isobe KI, Hibi T
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Journal Title
Gut 57(12)
Pages: 1682-1689
Related Report
Peer Reviewed
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[Journal Article] Exacerbating role of gammadelta T cells in chronic colitis of T-cell receptor alpha mutant mice.2008
Author(s)
Nanno M, Kanari Y, Naito T, Inoue N, Hisamatsu T, Chinen H, Sugimoto K, Shimomura Y, Yamagishi H, Shiohara T, Ueha S, Matsushima K, Suematsu M, Mizoguchi A, Hibi T, Bhan A K, Ishikawa H.
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Journal Title
Gastroenterology 134(2)
Pages: 481-490
Related Report
Peer Reviewed
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[Journal Article] Nonpathogenic Escherichia coli strain Nissle 1917 inhibits signal trans duction in intestinal epithelial cells.2008
Author(s)
Kamada N, Maeda K, Inoue N, Hisamatsu T, Okamoto S, Hong KS, Yamada T, Watanabe N, Tsuchimoto K, Ogata H, Hibi T.
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Journal Title
Infect Immun. 76(1)
Pages: 214-220
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Peer Reviewed
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[Presentation] MCP-1 依存性腸管マクロファージサブセットの腸管免疫恒常性における役割2008
Author(s)
高田康裕, 久松理一, 鎌田信彦, 斉藤理子, 高山哲朗, 市川仁志, 小林拓, 知念寛, 井上詠, 岡本晋, 日比紀文
Organizer
第45回日本消化器免疫学会
Place of Presentation
京都
Related Report
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