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Defective autophagy system against bacteria in Crohn's macrophages

Research Project

Project/Area Number 20590750
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKeio University

Principal Investigator

SUSUMU Okamoto  Keio University, 医学部, 講師 (70255446)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsクローン病 / オートファジー / マクロファージ
Research Abstract

The hypothesis of this study was that intestinal macrophages from Crohn's disease may have defect in autophagy system against intestinal bacteria. I performed immunohistochemistry and western blotting for samples both from human and murine Crohn's inflamed intestine using anti-LC-3 antibody. Disappointingly, I could not show any significant difference between normal control and Crohn's specimens in any series of experiments performed in this term. Now I am considering whether other experimental systems such as retroviral vectors or genetically engineered mice may be worth testing.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Remarks (1 results)

  • [Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.2010

    • Author(s)
      Mikami Y, Kanai T, Sujino T, Ono Y, Hayashi A, Okazawa A, Kamada N, Matsuoka K, Hisamatsu T, Okamoto S, Takaishi H, Inoue N, Ogata H, Hibi T
    • Journal Title

      Eur J Immunol. 40(9)

      Pages: 2409-22

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.2010

    • Author(s)
      Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, Matuzaki Y, Suzuki S, Sugita A, Koganei K, Hisamatsu T, Kanai T, Hibi T
    • Journal Title

      Gastroenterology. 139(3)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid endoscopic improvement is important for 1-year avoidance of colectomy but not for the long-term prognosis in cyclosporine A treatment for ulcerative colitis.2010

    • Author(s)
      Kobayashi T, Naganuma M, Okamoto S, Hisamatsu T, Inoue N, Ichikawa H, Takayama T, Saito R, Sujino T, Ogata H, Iwao Y, Hibi T
    • Journal Title

      J Gastroenterol. 45(11)

      Pages: 1129-37

    • NAID

      10027699761

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel endoscopic activity index is useful for choosing treatment in severe active ulcerative colitis patients.2010

    • Author(s)
      Naganuma M, Ichikawa H, Inoue N, Kobayashi T, Okamoto S, Hisamatsu T, Kanai T, Ogata H, Iwao Y, Hibi T
    • Journal Title

      J Gastroenterol. 45(9)

      Pages: 936-43

    • NAID

      10027698991

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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