Immuno-regulatory dysfunction in development of colitic dysplasia of patients with inflammatory bowel disease

• Project/Area Number: 20590751
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hyogo College of Medicine
• Principal Investigator: MATSUMOTO Takayuki Hyogo College of Medicine, 医学部, 教授 (10209637)
• Co-Investigator(Kenkyū-buntansha): IKEUCHI Hiroki 兵庫医科大学, 医学部, 教授 (80319863) ; HIDA Nobuyuki 兵庫医科大学, 医学部, 講師 (40340963) ; FUKUNAGA Ken 兵庫医科大学, 医学部, 講師 (80333540) ; OHDA Yoshio 兵庫医科大学, 医学部, 助教 (10388811)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 潰瘍性大腸炎 / クローン病 / 炎症性発癌 / 粘膜免疫 / サーベイランス / 発癌 / 免疫監視機構

Research Abstract

In the surveillance of colitic cancer in patients with long-standing inflammatory bowel disease, majority of the lesions were detectable under chromo-endoscopy, however, a part of flat lesions were not detectable. Photo-dynamic diagnosis (PDD) was useful to detect such lesions. Furthermore dysfunction in regulatory T cells and auto-reactive T cells were found in such long-standing cases, suggesting immune-regulatory dysfunction may play significant roles in the development of colitic neoplasia.

Research Products

• [Journal Article] Target biopsy or step biopsy? Optimal surveillance for ulcerative colitis : a Japanese nationwide randomized controlled trial (2011)
  • Author(s): Watanabe T, Ajioka Y, Matsumoto T, Tomotsugu N, Takebayashi T, Inoue E, Iizuka B, Igarashi M, Iwao Y, Ohtsuka K, Kudo S, Kobayashi K, Sada M, Matsumoto T, Hirata I, Murakami K, Nagahori M, Watanabe K, Hida N,, Ueno F, Tanaka S, Watanabe M, Hibi T
  • Journal Title: J Gastroenterol. 46巻(Suppl.1) Pages: 11-16
  • NAID: 10029029994
  • Peer Reviewed
• [Journal Article] Target biopsy or step biopsy? Optimal surveillance for ulcerative colitis : a Japanese nationwide randomized controlled trial. (2011)
  • Author(s): Watanabe T, Ajioka Y, Matsumoto T, Tomotsugu N, Takebayashi T, Inoue E, Iizuka B, Igarashi M, Iwao Y, Ohtsuka K, Kudo S, Kobayashi K, Sada M, Matsumoto T, Hirata I, Murakami K, Nagahori M, Watanabe K, Hida N, Ueno F, Tanaka S, Watanabe M, Hibi T.
  • Journal Title: J Gastroenterol. Volume: 46(Suppl.1) Pages: 11-16
  • NAID: 10029029994
  • Peer Reviewed
• [Journal Article] 直腸炎と癌に関係はあるのか (2010)
  • Author(s): 樋田信幸、松本譽之
  • Journal Title: Intestine 14巻 Pages: 619-622
  • Peer Reviewed
• [Journal Article] Colitic cancer/dysplasiaの内視鏡診断 (2010)
  • Author(s): 樋田信幸、松本譽之
  • Journal Title: Modern Physician 30巻 Pages: 969-972
• [Journal Article] Colitic cancer/dysplasiaの内視鏡診断 (2010)
  • Author(s): 樋田信幸, 松本譽之
  • Journal Title: Modern Physician Volume: 30 Pages: 969-972
• [Journal Article] 直腸炎と癌に関係はあるのか (2010)
  • Author(s): 樋田信幸, 松本譽之
  • Journal Title: Intestine Volume: 14 Pages: 619-622
  • Peer Reviewed
• [Journal Article] Treating ulcerative colitis by Adacolumn therapeutic leucocytapheresis : Clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan. (2009)
  • Author(s): Hibi T, Sameshima Y, Sekiguchi Y, Hisatome Y, Maruyama F, Moriwaki K, Shima C, Saniabadi AR, Matsumoto T.
  • Journal Title: Dig.Liver Dis. 41巻 Pages: 570-577
  • Peer Reviewed
• [Journal Article] 潰瘍性大腸炎長期罹患症例に対するサーベイランスのための腫瘍性病変内視鏡アトラス (2009)
  • Author(s): 樋田信幸、松本譽之
  • Journal Title: Intestine 13巻 Pages: 90-91
  • Peer Reviewed
• [Journal Article] NBIによる潰瘍性大腸炎のサーベイランス (2009)
  • Author(s): 樋田信幸、松本譽之
  • Journal Title: Intestine 13巻 Pages: 283-288
  • Peer Reviewed
• [Journal Article] The expression profile of the functional regulatory T cells, CD4+CD25High+/FOXP3+, in patients with ulcerative colitis during active and quiescent disease. (2009)
  • Author(s): Kamikozuru K, Fukunaga K, Hirota S, Hida N, Ohda Y, Yoshida K, Y Yokoyama, Tozawa K, Kawa K, Iimuro M, Nagase K, Saniabadi AR, Nakamura S, Miwa H, Matsumoto T
  • Journal Title: Clin Exp Immnol 156巻 Pages: 320-327
  • Peer Reviewed
• [Journal Article] 潰瘍性大腸炎長期罹患症例に対するサーベイランスのための腫瘍性病変内視鏡アトラス. (2009)
  • Author(s): 樋田信幸, 松本譽之
  • Journal Title: Intestine 13 Pages: 90-91
  • Peer Reviewed
• [Journal Article] NBIによる潰瘍性大腸炎のサーベイランス. (2009)
  • Author(s): 樋田信幸, 松本譽之.
  • Journal Title: Intestine 13 Pages: 283-288
  • Peer Reviewed
• [Journal Article] Treating ulcerative colitis by Adacolumn therapeutic leucocy tapheresis : Clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan. (2009)
  • Author(s): Hibi T, Sameshima Y, Sekiguchi Y, Hisatome Y, Maruyama F, Moriwaki K, Shima C, Saniabadi AR, Matsumoto T.
  • Journal Title: Dig.Liver Dis. 41 Pages: 570-577
  • Peer Reviewed
• [Journal Article] 炎症性腸疾患と発癌 (2008)
  • Author(s): 松本譽之、樋田信幸
  • Journal Title: 日本内科学会雑誌 97巻 Pages: 503-507
  • NAID: 10021253538
• [Journal Article] 多彩な病理形態を示したColitic Cancerの1例 (2008)
  • Author(s): 内野基、池内浩基、松岡宏樹、田中慶太、久野隆史、大嶋勉、塚本潔、中村光宏、外賀真、中埜廣樹、野田雅史、樋田信幸、松本譽之、竹末芳生、冨田尚裕
  • Journal Title: 日本大腸肛門病学会誌 67巻 Pages: 267-271
  • NAID: 10021941536
  • Peer Reviewed
• [Journal Article] Endoscopic and chromoendoscopic atlas featuring dysplastic lesions in surveillance colonoscopy for patients with long-standing ulcerative colitis (2008)
  • Author(s): Matsumoto T, Iwao Y, Igarashi M., Watanabe K, Otsuka K, Watanabe T, Iizuka B, Hida N, Sada M, Chiba T, Kudo S.E, Oshitani N, Nagawa H, Ajioka Y, Hibi T
  • Journal Title: Inflamm. Bowel Dis. 14巻 Pages: 259-264
  • Peer Reviewed
• [Journal Article] Endoscopic and chromoendoscopic atlas featuring dysplastic lesions in surveillance colonoscopy for patients with long-standing ulcerative colitis. (2008)
  • Author(s): Matsumoto, T., Iwao, Y., Igarashi, M., Watanabe, K., Otsuka, K., Watanabe, T., Iizuka, B., Hida, N., Sada, M., Chiba, T., Kudo, S. E., Oshitani, N., Nagawa, H., Ajioka, Y., Hibi, T.
  • Journal Title: Inflamm. Bowel Dis. 14 Pages: 259-264
  • Peer Reviewed
• [Journal Article] 多彩な病理形態を示したColitic Cancerの1例 (2008)
  • Author(s): 内野基, 池内浩基, 松岡宏樹, 田中慶太, 久野隆史, 大嶋勉, 塚本潔, 中村光宏, 外賀真, 中埜廣樹, 野田雅史, 樋田信幸, 松本譽之, 竹末芳生, 冨田尚裕
  • Journal Title: 日本大腸肛門病学会誌 67 Pages: 267-271
  • NAID: 10021941536
  • Peer Reviewed
• [Journal Article] 炎症性腸疾患と発癌 (2008)
  • Author(s): 松本譽之, 樋田信幸
  • Journal Title: 日本内科学会雑誌 97 Pages: 503-507
  • NAID: 10021253538
• [Presentation] 治癒切除後10年で骨盤内再発をきたしたクローン病直腸mucinous carcinomaの1例 (2010)
  • Author(s): 坂東俊宏,松岡宏樹,内野基,池内浩基,松本譽之,竹末芳生,冨田尚裕
  • Organizer: 第65回日本大腸肛門病学会学術集会
  • Place of Presentation: 浜松
  • Year and Date: 2010-11-27
• [Presentation] 治癒切除後10年で骨盤内再発をきたしたクローン病直腸mucinous carcinomaの1例 (2010)
  • Author(s): 坂東俊宏, 松岡宏樹, 内野基, 池内浩基, 松本譽之, 竹末芳生, 冨田尚裕
  • Organizer: 第65回日本大腸肛門病学会学術集会
  • Place of Presentation: アクトシティ浜松(静岡県)
  • Year and Date: 2010-11-27
• [Presentation] 潰瘍性大腸炎に発生する平坦型dysplasiaの臨床像 (2010)
  • Author(s): 樋田信幸,堀和敏,松本譽之
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-23
• [Presentation] Random or target biopsies for colitic cancer surveillance? (2010)
  • Author(s): Watanabe T, Ajioka Y, Matsumoto T, Hibi T, Watanabe M
  • Organizer: 第96回日本消化器病学会総会 The 2nd International Forum
  • Place of Presentation: 福岡
  • Year and Date: 2010-04-23
• [Presentation] Therapeutic options for ulcerative colitis in Japan (2010)
  • Author(s): 松本譽之
  • Organizer: 第96回日本消化器病学会総会 The 2nd International Forum
  • Place of Presentation: 福岡
  • Year and Date: 2010-04-23
• [Presentation] Therapeutic options for ulcerative colitis in Japan. (2010)
  • Author(s): 松本譽之
  • Organizer: 第96回日本消化器病学会総会The 2^<nd> International Forum
  • Place of Presentation: 福岡国際会議場(福岡県)(指定講演)
  • Year and Date: 2010-04-23
• [Presentation] Random or target biopsies for colitic cancer surveillance? (2010)
  • Author(s): Watanabe T, Ajioka Y, Matsumoto T, Hibi T, Watanabe M.
  • Organizer: 第96回日本消化器病学会総会The 2^<nd> International Forum
  • Place of Presentation: 福岡国際会議場(福岡県)(指定講演)
  • Year and Date: 2010-04-23
• [Presentation] 潰瘍性大腸炎に発生する平坦型dysplasiaの臨床像 (2010)
  • Author(s): 樋田信幸, 堀和敏, 松本譽之
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟県民会館(新潟県)(シンポジウム)
  • Year and Date: 2010-04-23
• [Presentation] A clinical follow-up study of three subtypes of dysplasiaassociated lesions or masses in Japanese patients with chronic ulcerative colitis (2009)
  • Author(s): Hida N,Hori K, Fukunaga K, Ohda Y, Iimuro M, Yoshida K, Yokoyama Y, Kamikozuru K, Nakamura S, 松本譽之
  • Organizer: GASTRO 2009(UEGW/WCOG) 2009
  • Place of Presentation: ロンドン(イギリス)
  • Year and Date: 2009-11-24
• [Presentation] A clinical follow-up study of three subtypes of dysplasiaassociated lesions or masses in Japanese patients with chronic ulcerative colitis. (2009)
  • Author(s): Hida N, Hori K, Fukunaga K, Ohda Y, Iimuro M, Yoshida K, Yokoyama Y, Kamikozuru K, Nakamura S, Matsumoto T.
  • Organizer: GASTRO 2009(UEGW/WCOG)2009.
  • Place of Presentation: ロンドン
  • Year and Date: 2009-11-24
• [Presentation] クローン病の臨床病態と素因-肉芽腫性疾患としての意義 (2009)
  • Author(s): 松本譽之
  • Organizer: 第29回日本サルコイドーシス/肉芽腫性疾患学会総会
  • Place of Presentation: 宇都宮
  • Year and Date: 2009-10-21
• [Presentation] クローン病の臨床病態と素因-肉芽腫性疾患としての意義. (2009)
  • Author(s): 松本譽之.
  • Organizer: 第29回日本サルコイドーシス/肉芽腫性疾患学会総会
  • Place of Presentation: 宇都宮
  • Year and Date: 2009-10-21
• [Presentation] 潰瘍性大腸炎合併腫瘍性病変の取り扱いと経過 (2009)
  • Author(s): 樋田信幸,堀和敏,松本譽之
  • Organizer: 第51回日本消化器病学会大会・第78回日本消化器内視鏡学会総会(JDDW2009)
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] 潰瘍性大腸炎合併腫瘍性病変の取り扱いと経過. (2009)
  • Author(s): 樋田信幸, 堀和敏, 松本譽之
  • Organizer: 第51回日本消化器病学会大会・第78回日本消化器内視鏡学会総会(JDDW2009)
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] 腸結核による慢性炎症から発生したと考えられる早期大腸癌の検討-(UCを背景とするdysplasiaとの比較) (2009)
  • Author(s): 應田義雄,西上隆之,松本譽之
  • Organizer: 第83回日本消化器内視鏡学会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-09
• [Presentation] 腸結核にみる慢性炎症から発生したと考えられる早期大腸癌の検討-(UCを背景とするdysplasiaとの比較). (2009)
  • Author(s): 應田義雄, 西上隆之, 松本譽之
  • Organizer: 第83回日本消化器内視鏡学会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-09
• [Presentation] 潰瘍性大腸炎に発生したdysplasiaの追跡研究 (2009)
  • Author(s): 樋田信幸,堀和敏,松本譽之
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-09
• [Presentation] 潰瘍性大腸炎に発生したdysplasiaの追跡研究. (2009)
  • Author(s): 樋田信幸, 堀和敏, 松本譽之
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-09
• [Presentation] 潰瘍性大腸炎関連腫瘍に対する光線力学的診断法の有用性の検討-invisible flat dysplasiaの視認に向けて- (2008)
  • Author(s): 樋田信幸,渡辺憲治,味岡洋一,堀和敏,押谷伸英,中村志郎,荒川哲男,松本譽之
  • Organizer: 第26回日本大腸検査学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-30
• [Presentation] 潰瘍性大腸炎関連腫瘍に対する光線力学的診断法の有用性の検討-invisible flat dysplasiaの視認に向けて-. (パネルディスカッション) (2008)
  • Author(s): 樋田信幸, 渡辺憲治, 味岡洋一, 堀和敏, 押谷伸英, 中村志郎, 荒川哲男, 松本譽之
  • Organizer: 第26回日本大腸検査学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-30
• [Presentation] Demonstration of low CD25 high+CD4+ and highCD28-CD4+ T-cell subsets in patients with ulcerative colitis (2008)
  • Author(s): Yokoyama Y, Fukunaga K, Kamikozuru K, Nakmaura S, Miwa H, Matsumoto T
  • Organizer: The 16th United European Gastroenterology Week (UEGW2008)
  • Place of Presentation: ウィーン(オーストリア)
  • Year and Date: 2008-10-22
• [Presentation] In patients with active ulcerative colitis, selective depletion of granulocytes and monocytes by extracorporeal adsorption impacts peripheral and mucosal level of CD4+ regulatory T-cells (2008)
  • Author(s): Kamikozuru K, Fukunaga K, Hirota S, Yokoyama Y, Ohda Y, Hida N, Nakamura S, Miwa H, Matsumoto, T
  • Organizer: The 16th United European Gastroenterology Week (UEGW2008)
  • Place of Presentation: ウィーン(オーストリア)
  • Year and Date: 2008-10-22
• [Presentation] In patients with active ulcerative colitis, selective depletion of granulocytes and monocytes by extracorporeal adsorption impacts peripheral and mucosal level of CD4+ regulatory T-cells. (2008)
  • Author(s): Kamikozuru, K., Fukunaga, K., Hirota, S., Yokoyama, Y., Ohda, Y., Hida, N., Nakamura, S., Miwa, H., Matsumoto, T.
  • Organizer: The 16th United European Gastroenterology Week (UEGW2008)
  • Place of Presentation: ウィーン(オーストリア)
  • Year and Date: 2008-10-22
• [Presentation] Demonstration of low CD25 high+CD4+ and highCD28-CD4+ T-cell subsets in patients with ulcerative colitis. (2008)
  • Author(s): Yokoyama, Y., Fukunaga, K., Kamikozuru, K., Nakmaura, S., Miwa, H., Matsumoto, T.
  • Organizer: The 16th United European Gastroenterology Week (UEGW2008)
  • Place of Presentation: ウィーン(オーストリア)
  • Year and Date: 2008-10-22
• [Presentation] Expression of the peripheral CD25high+CD4+ regulatory T-cells define the immunological characteristics of IBD (2008)
  • Author(s): Fukunaga K, Yoshida K, Kamikozuru K, Miwa H, Matsumoto T
  • Organizer: The 16th United European Gastroenterology Week (UEGW2008)
  • Place of Presentation: ウィーン(オーストリア)
  • Year and Date: 2008-10-20
• [Presentation] Expression of the- peripheral CD25high+CD4+ regulatory T-cells define the immunological characteristics of IBD. (2008)
  • Author(s): Fukunaga, K., Yoshida, K., Kamikozuru, K., Miwa, H., Matsumoto, T.
  • Organizer: The 16th United European Gastroenterology Week (UEGW2008)
  • Place of Presentation: ウィーン(オーストリア)
  • Year and Date: 2008-10-20
• [Presentation] For the establishment of surveillance of colitic cancer (2008)
  • Author(s): Watanabe T, Matsumoto T, Watanabe M, Hibi T
  • Organizer: The 3rd Japan-Korea IBD symposium
  • Place of Presentation: ソウル(大韓民国)
  • Year and Date: 2008-09-20
• [Presentation] The Expression of CD25highCD4+ T-cells and CD28-CD4+ T-cells in ulcerative colitis (2008)
  • Author(s): Yokoyama Y, Fukunaga K, Ikeuchi H, Kamikozuru K, Tozawa K, Uchino M, Yoshida K, Hida N, Nakamura S, Miwa H, Matsumoto T
  • Organizer: The 3rd Japan-Korea IBD symposium
  • Place of Presentation: ソウル(大韓民国)
  • Year and Date: 2008-09-20
• [Presentation] The Expression of CD25highCD4+ T-cells and CD28-CD4+ T-cells in ulcerative colitis. (2008)
  • Author(s): Yokoyama, Y., Fukunaga, K., Ikeuchi, H., Kamikozuru, K., Tozawa, K., Uchino, M., Yoshida, K., Hida, N., Nakamura, S., Miwa, H., Matsumoto, T.
  • Organizer: The 3^<rd> Japan-Korea IBD symposium
  • Place of Presentation: ソウル(大韓民国)
  • Year and Date: 2008-09-20
• [Presentation] For the establishment of surveillance of colitic cancer. (2008)
  • Author(s): Watanabe, T., Matsumoto, T., Watanabe, M., Hibi, T.
  • Organizer: The 3^<rd> Japan-Korea IBD symposium
  • Place of Presentation: ソウル(大韓民国)
  • Year and Date: 2008-09-20
• [Presentation] Fluorescence endoscopy for further workup of neoplastic lesions in ulcerative colitis using local 5-aminolaevulinic acid-induced photosensitization (2008)
  • Author(s): Hida N, Watanabe K, Oshitani N, Arakawa T, Matsumoto T
  • Organizer: Digestive Disease Week and the 109th Annual Meeting of the AGA Institute (DDW2008)
  • Place of Presentation: サンディエゴ(アメリカ)
  • Year and Date: 2008-05-20
• [Presentation] Fluorescence endoscopy for further workup of neoplastic lesions in ulcerative colitis using local 5-aminolaevulinic acid-induced photosensitization. (2008)
  • Author(s): Hida, N., Watanabe, K., Oshitani, N., Arakawa, T., Matsumoto, T.
  • Organizer: Digestive Disease Week and the 109th Annual Meeting of the AGA Institute (DDW2008)
  • Place of Presentation: サンデイェゴ(アメリカ)
  • Year and Date: 2008-05-20
• [Book] 炎症性腸疾患(癌化・dysplasiaのサーベイランス) (2010)
  • Author(s): 樋田信幸,松本譽之
• [Book] 炎症性腸疾患 (2010)
  • Author(s): 樋田信幸, 松本譽之
  • Publisher: 癌化・dysplasiaのサーベイランス