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Molecular Screening by Microarray analysis for Hepatocarcinogenesis.

Research Project

Project/Area Number 20590752
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHokkaido University

Principal Investigator

CHUMA Makoto  Hokkaido University, 病院, 助教 (30360910)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Takahiko  北海道大学, 大学院・医学研究科, 客員研究員 (80333607)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords癌進展 / RNA結合タンパク / RBM5 / マイクロアレイ / 網羅的探索 / 肝癌発生
Research Abstract

The expression of the RBM5 mRNA is decreased in cancer tissues. Overexpression of RBM5 enhanced p53-mediated inhibition of cancer cell growth and colony formation. RBM5 affected p53 transcriptional activity and levels of mRNA and protein for endogenous p53 target genes. RBM5 influenced protein, but not mRNA, levels of endogenous p53 suggesting that RBM5 contributes to p53 activity through post-transcriptional mechanisms. Our results show that RBM5 contributes to p53 transcriptional activity, and that growth suppression and apoptosis mediated by RBM5 are linked to activity of the tumor suppressor protein p53.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009 2008

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (5 results)

  • [Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.2011

    • Author(s)
      Kobayashi T, Ishida J, Musashi M, Ota S, Yoshida T, Shimizu Y, Chuma M, Kawakami H, Asaka M, Tanaka J, Imamura M, Kobayashi M, Itoh H, Edamatsu H, Sutherland LC, Brachmann RK.
    • Journal Title

      Int J Cancer. 128(2)

      Pages: 304-318

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative turnor suppressor RBM5.2011

    • Author(s)
      Kobayashi T
    • Journal Title

      Int J Cancer

      Volume: 128 Pages: 304-318

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive assay for quantification of hepatitis B virus mutants by use of a minor groovebinder probe and peptide nucleic acids.2010

    • Author(s)
      Hige S
    • Journal Title

      J Cli Microbiol

      Volume: 48 Pages: 4487-4494

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The influence of hepatitis B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma.2009

    • Author(s)
      Chuma M, Hige S, Kamiyama T, Meguro T, Nagasaka A, Nakanishi K, Yamamoto Y, Nakanishi M, Kohara T, Sho T, Yamamoto K, Horimoto H, Kobayashi T, Yokoo H, Matsushita M, Todo S, Asaka M.
    • Journal Title

      J Gastroenterol. 44(9)

      Pages: 991-999

    • NAID

      10025581551

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The influence of hepatitis B DNA level and antiviral therapy on recurrence afterinitial curative treatment in patients with hepatocellular carcinoma.2009

    • Author(s)
      Chuma M
    • Journal Title

      J Gastroenterol. 23

      Pages: 991-999

    • NAID

      10025581551

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunological and mutagenic actions of ribavirin monotherapy preceding combination therapy with interferon for patients with chronic hepatitis C.2009

    • Author(s)
      Ogawa K
    • Journal Title

      Antivir Ther. 14

      Pages: 513-522

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 8-OHdG is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.2008

    • Author(s)
      Chuma M, Hige S, Nakanishi M, Ogawa K, Natsuizaka M, Yamamoto Y, Asaka M.
    • Journal Title

      J Gastroenterol Hepatol. 23(9)

      Pages: 1431-1436

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 8-OHdG is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection2008

    • Author(s)
      Chuma M
    • Journal Title

      J Gastroenterol Hepatol. 23

      Pages: 1431-1436

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abscopal effect on hepatocellular carcinoma2008

    • Author(s)
      Nakanishi M
    • Journal Title

      Am J Gastroenterol 103

      Pages: 1320-1321

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肝細胞癌根治後の再発に関するHBV-DNA量、抗ウイルス薬の影響2010

    • Author(s)
      中馬誠
    • Organizer
      第38回日本肝臓学会東部会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝細胞癌根治後の再発に関するHBV-DNA量、抗ウイルス薬の関与2009

    • Author(s)
      中馬誠
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Influence of Hepatitis B DNA Level and Antiviral Therapy on Recurrence After Initial Curative Treatment in Patients With Hepatocellular Carcinoma.2009

    • Author(s)
      Chuma M.
    • Organizer
      第19回 アジア太平洋肝臓学会
    • Place of Presentation
      香港
    • Year and Date
      2009-02-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 8-OHdG is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.2008

    • Author(s)
      Chuma M.
    • Organizer
      第43回欧州肝臓学会
    • Place of Presentation
      ミラノ
    • Year and Date
      2008-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 8-OHdG is a risk factor for development of hepatocellular carcinoma in natients with chronic hepatitis C virus infection2008

    • Author(s)
      Chuma M
    • Organizer
      第43回欧州肝臓学会
    • Place of Presentation
      イタリア・ミラノ
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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