Molecular mechanism of overlap between chronic liver disease and iron metabolism abnormality
| Project/Area Number |
20590754
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKUTA Katsuya 旭川医科大学, 医学部, 講師 (00396376)
SASAKI Katsunori 旭川医科大学, 医学部, 特任准教授 (60336394)
SATOU Kazuya 旭川医科大学, 医学部, 講師 (50360988)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 非アルコール性脂肪性肝疾患 / アルコール性肝障害 / トランスフェリン受容体 / ヘプシジン / 鉄トランスポーター / 非トランスフェリン結合鉄 / 非アルコール性脂肪性肝炎 |
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| Research Abstract |
Excess iron is frequently accumulated in chronic liver diseases. The pathogenesis and iron metabolism abnormality are overlapped, which may be progressed by the interaction. Non-alcoholic fatty liver disease (NAFLD) also frequently merges with secondary hepatic iron accumulation, which contributes to the development of oxidative stress, liver cell damage, fibrosis and carcinogenesis. In this study, we investigated the expression of iron-related molecules in liver and duodenum tissue in mice fatty liver model and human hepatocellular in vitro model. Obesity and high-fat diet up-regulate TfR1 expression and down-regulate Hepc expression in the liver. Furthermore they up-regulate the iron transporter expressions in the duodenum.
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Report
(6 results)
Research Products
(69 results)
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[Presentation] Alcohol-loading and obesity regulate the expression of transferrin receptor 1 and hepcidin in mice liver2010
Author(s)
Ohtake T, Ikuta K, Hasebe S, Nakajima S, Sawada K, Abe M, Hosoki T, Suzuki Y, Sasaki K, Torimoto Y, Kohgo Y.
Organizer
Falk Workshop
Place of Presentation
Freiburg, Germany.
Related Report
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[Presentation] 非アルコール性脂肪肝における非トランスフェリン結合鉄(NTBI)の検討.2010
Author(s)
大竹孝明, 生田克哉, 長谷部拓夢, 中嶋駿介, 澤田康司, 阿部真美, 鈴木康秋, 田中宏樹, 佐々木勝則, 鳥本悦宏, 高後裕.
Organizer
第34回日本鉄バイオサイエンス学会学術集会
Place of Presentation
東京
Related Report
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[Presentation] Alcohol-loading and obesity regulate the expression of transferrin receptor 1 and hepcidin in mice liver.2010
Author(s)
Ohtake T, Ikuta K, Hasebe S, Nakajima S, Sawada K, Abe M, Hosoki T, Suzuki Y, Sasaki K, Torimoto Y, Kohgo Y.
Organizer
Falk Workshop
Place of Presentation
Freiburg, Germany
Related Report
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[Presentation] Metabolic steatosis and alcohol-loading regulate the expression of transferrin receptor 1 and hepcidin in mice liver2009
Author(s)
Ohtake T, Ikuta K, Sawada K, Abe M, Hosoki T, Miyoshi S, Suzuki Y, Sasaki K, Torimoto Y, Kohgo Y
Organizer
2009 International BioIron Society Meeting
Place of Presentation
Porto, Portugal
Related Report
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[Presentation] Metabolic steatosis and alcohol-loading regulate the expression of transferrin receptor 1 and hepcidin in mice liver.2009
Author(s)
Ohtake T, Ikuta K, Sawada K, Abe M, Hosoki T, Miyoshi S, Suzuki Y, Sasaki K, Torimoto Y, Kohgo Y
Organizer
2009 International BioTron Society Meeting
Place of Presentation
Porto, Portugal
Related Report
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