Involvement of fatty acids and Kupffer cells for development of liver disease

• Project/Area Number: 20590755
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tohoku University
• Principal Investigator: FUKUSHIMA Koji Tohoku University, 病院, 助教 (20400476)
• Co-Investigator(Kenkyū-buntansha): 上野 義之 東北大学, 病院, 准教授 (70282126)
• Research Collaborator: NORIYUKI Obara 東北大学, 大学院・医学系研究科, 大学院生
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 肝臓学 / 非アルコール性脂肪性肝炎 / トランス脂肪酸 / クッパー細胞 / TNFα / 脂肪合成 / 脂肪性肝疾患 / NAFLD / NASH / 脂肪酸 / TNF / 炎症 / 肝臓 / インスリン抵抗性 / Kupffer細胞 / autophagy

Research Abstract

We clarified the pathogenic mechanism of trans-fatty acid to the mouse liver summarized as caused by the upregulation of lipogenesis in the liver and elevated level of free fatty acids accompanied by the secretion of TNF-a by Kupffer cells.

Research Products

• [Journal Article] Possible involvement and the mech anisms of excess trans-fatty acid consumptio n in severe NAFLD in mice. (2010)
  • Author(s): 小原範之, 福島耕治, 上野義之
  • Journal Title: Journal of Hepa tology 53(2) Pages: 326-334
  • Peer Reviewed
• [Journal Article] Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice. (2010)
  • Author(s): 小原範之、福島耕治
  • Journal Title: Journal of Hepatology Volume: 53(2) Pages: 326-34
  • Peer Reviewed
• [Journal Article] Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice (2010)
  • Author(s): Obara, N, Fukushima, K, Ueno, Y, et al
  • Journal Title: J of Hepatology (In press)
  • Peer Reviewed
• [Journal Article] クッパー細胞に対する遊離脂肪酸の生理学的作用 (2008)
  • Author(s): 小原範之, 福島耕治, 上野義之, 下瀬川徹
  • Journal Title: Jpn Pharmacol Ther 36(s2)
• [Journal Article] クッパー細胞に対する遊離脂肪酸の生理学的作用 (2008)
  • Author(s): 小原範之、福島耕治、上野義之
  • Journal Title: 薬理と治療 36
• [Presentation] トランス脂肪酸マウスモデルの病態解析 (2010)
  • Author(s): 福島耕治、小原範之、上野義之
  • Organizer: 日本肝臓学会、消化器病学会、消化吸収学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14
• [Presentation] トランス脂肪酸マウスモデルの病態解析 (2010)
  • Author(s): 福島耕治
  • Organizer: 日本消化器病学会・肝臓学会・消化吸収学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-10-14
• [Presentation] トランス脂肪酸高含有特殊脂肪食による脂肪性肝疾患の惹起と発症機序 (2010)
  • Author(s): 小原範之、福島耕治、上野義之
  • Organizer: 日本消化器病学会
  • Place of Presentation: 山形
  • Year and Date: 2010-05-27
• [Presentation] トランス脂肪酸と肝関連指標に関する検討 (2010)
  • Author(s): 福島耕治、小原範之、上野義之
  • Organizer: 日本静脈経腸栄養学会
  • Place of Presentation: 千葉・幕張
  • Year and Date: 2010-02-26
• [Presentation] トランス脂肪酸と肝関連指標に関する検討(フェローシップ賞受賞者講演) (2010)
  • Author(s): 福島耕治、小原範之、上野義之
  • Organizer: 日本静脈経腸栄養学会
  • Place of Presentation: 幕張
  • Year and Date: 2010-02-25
• [Presentation] Trans fatty acid containing high fat diet induced nonalcoholic fatty liver disease in mice (2009)
  • Author(s): 小原範之, 福島耕治, 上野義之
  • Organizer: AASLD
  • Place of Presentation: アメリカ・ボストン
  • Year and Date: 2009-11-05
• [Presentation] Trans fatty acid containing high fat diet induced nonalcoholic fatty liver disease in mice (2009)
  • Author(s): 小原範之, 福島耕治, 上野義之
  • Organizer: 米国肝臓学会
  • Place of Presentation: ボストン(アメリカ)
  • Year and Date: 2009-11-02
• [Presentation] Mouse model of nonalcoholic fatty liver disease induced by long term feeding of trans-fat rich high-fat diet (2009)
  • Author(s): 小原範之, 福島耕治, 上野義之
  • Organizer: 欧州肝臓学会
  • Place of Presentation: ボローニャ(イタリア)
  • Year and Date: 2009-09-26
• [Presentation] Mouse model of nonalcoholic fatty liver disease induced by long term feeding of trans-fat rich high-fat diet (2009)
  • Author(s): 小原範之, 福島耕治, 上野義之
  • Organizer: EASL
  • Place of Presentation: イタリア・ボローニャ
  • Year and Date: 2009-09-24
• [Presentation] Fatty liver disease model caused by long-term feeding of trans-fatty acids (2009)
  • Author(s): 福島耕治, 小原範之, 上野義之
  • Organizer: ESPEN
  • Place of Presentation: オーストリア・ウイーン
  • Year and Date: 2009-09-02
• [Presentation] Fatty liver disease model caused by long-term feeding of trans-fatty acids (2009)
  • Author(s): 福島耕治, 小原範之, 上野義之
  • Organizer: 欧州経腸栄養学会
  • Place of Presentation: ウイーン(オーストリア)
  • Year and Date: 2009-09-01
• [Presentation] トランス脂肪酸と肝関連指標に関する検討 (2009)
  • Author(s): 福島耕治、小原範之、上野義之
  • Organizer: 日本静脈経腸栄養学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2009-01-29
• [Presentation] Non alcoholic steatohepatitis(NASH)で認められる高脂肪酸血症の病態への意義 (2008)
  • Author(s): 小原範之、福島耕治、上野義之
  • Organizer: 日本肝臓学会
  • Place of Presentation: 松山
  • Year and Date: 2008-06-06