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The role of endoplasmic reticulum (ER) stress in non-alcoholic steatohepatitis

Research Project

Project/Area Number 20590758
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionGunma University

Principal Investigator

SATO Ken  Gunma University, 医学部, 助教 (40396619)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords発現制御 / ストレス / シグナル伝達 / 遺伝子 / 病理学
Research Abstract

The role of endoplasmic reticulum (ER) stress in nonalcoholic steatohepatitis has not been fully elucidated. Because CHOP is one of the ER stress-related molecules, we compared CHOP knock out (KO) mice and wild type (WT) mice in steatohepatitis mice model using a methionine-choline (MCD) deficient diet. Steatosis and neutrophil infiltration, and apoptosis in liver tissue were significantly attenuated in KO mice compared with WT mice at 1 week after the administration of MCD diet. But these significant differences were transient. The time to peak level of the expression of PPAR γ was different between KO mice and WT mice. This may be one of the causes of the difference of pathophysiologic change between KO mice and WT mice.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2011 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Transforming growth factor-α attenuates hepatic fibrosis : possible involvement of matrix metalloproteinase-1.2011

    • Author(s)
      Ohyama T, Yamazaki Y, Sato K, Horiguchi N, Ichikawa T, Kakizaki S, Takagi H, Mori M.
    • Journal Title

      Liver Int. 31(4)

      Pages: 572-84

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transforming growth factor-α attenuates hepatic fibrosis : possible involvement of matrix metalloproteinase-1.2011

    • Author(s)
      Ohyama T, Sato K, et al.
    • Journal Title

      Liver Int.

      Volume: 31 Pages: 572-584

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Werner syndrome as a possible cause of non-alcoholic steatohepatitis.2009

    • Author(s)
      Hashizume H, Sato K, Takagi H, Kanda D, Kashihara T, Kiso S, Mori M.
    • Journal Title

      J Clin Pathol 62(11)

      Pages: 1043-5

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Transforming growth factor-α attenuates hepatic fibrosis : possible involvement of matrix metalloproteinase-1.2011

    • Organizer
      DDW
    • Place of Presentation
      Mccormick place (Chicago, USA).
    • Year and Date
      2011-05-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Werner syndrome as a possible cause of non-alcoholic steatohepatitis.2010

    • Organizer
      The 9^<th> JSH Single Conference.
    • Place of Presentation
      グランドプリンス高輪(東京、日本)
    • Year and Date
      2010-11-25
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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