The role and crosstalk between nuclear receptors PXR and CAR on the pathogenesis of non-alcoholic steatohepatitis.
| Project/Area Number |
20590759
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YOSHINARI Koichi 東北大学, 薬学研究科(研究院), 准教授 (60343399)
|
|---|
| Project Period (FY) |
2008 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 非アルコール性脂肪性肝炎 / 核内レセプター / CAR / PXR / Cytochrome P450 / 肝線維化 / Ctochrome P450 |
|---|
| Research Abstract |
The roles and crosstalk between nuclear receptors PXR and CAR on the pathogenesis of non-alcoholic steatohepatitis (NASH) were evaluated in this study. CAR accelerated the production of reactive oxygen species (ROS) and worsened the liver injury and fibrosis in the NASH model using methionine-and choline-deficient diet. There were no differences in NASH between PXR knockout and wild-type mice. CAR play a role in the hepatocarcinogenesis of the murine NASH model via the upregulation of cell proliferation.
|
Report
(6 results)
Research Products
(47 results)
