A study on the effects of HBV-DNA integration on non-B non-C hepatocellular carcinoma

• Project/Area Number: 20590762
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: YOSHIDA Haruhiko The University of Tokyo, 医学部附属病院, 講師 (60240305)
• Co-Investigator(Kenkyū-buntansha): GOTO Tadashi 東京大学, 医学部附属病院, 助教 (40444088)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肝細胞癌 / 非B非C肝癌 / HBV-DNA / 非B非C肝障害 / HBV-DNA量 / ラジオ波焼灼療法 / 多変量解析 / HBV既感染 / C型慢性肝炎 / HBc抗体 / Cox比例ハザードモデル / 内臓脂肪 / 非アルコール性脂肪肝炎

Research Abstract

We evaluated the influence of HBc antibody seropositivity in (1) the recurrence of non-B non-C hepatocellular carcinoma (HCC) after curative treatment, (2) in the development of HCC among patients with non-B non-C chronic liver disease, and (3) in the development of HCV-related HCC. HBc antibody positivity was found to be a significant risk factor in none. Serum HBV load was associated with the risk of recurrence of HBV-related HCC.

Research Products

• [Journal Article] Influence of serum HBV DNA load on recurrence of hepatocellular carcinoma after treatment with percutaneous radiofrequency ablation (2011)
  • Author(s): Goto T, Yoshida H, 他10名
  • Journal Title: Hepatology International Volume: (Published Online,掲載確定)
  • Peer Reviewed
• [Journal Article] Influence of HBcAb seropositivity on the risk of hepatocellular carcinoma in HCV infected patients. (2010)
  • Author(s): Ohki T, Tateishi R, Goto E, Sato T, Masuzaki R, Imamura J, Goto T, Kanai F, Shiina S, Yoshida H, Kawabe T, Omata M
  • Journal Title: J Viral Hepatitis. 17 Pages: 91-7
  • Peer Reviewed
• [Journal Article] Influence of anti-HBc seropositivity on the risk of hepatocellular carcinoma in HCV-infected patients after adjusting for confounding factors. (2010)
  • Author(s): Ohki T, Goto T, Yoshida H, 他10名
  • Journal Title: Journal of Viral Hepatitis 17 Pages: 91-97
  • Peer Reviewed
• [Journal Article] Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment inpatients with suspected NASH. (2009)
  • Author(s): Ohki T, Tateishi R, Shiina S, Goto E, Sato T, Nakagawa H, Masuzaki R, Goto T, Hamamura K, Kanai F, Yoshida H, Kawabe T, Omata M
  • Journal Title: Gut 58 Pages: 839-44
  • Peer Reviewed
• [Journal Article] Obesity is an independent risk factor for hepatocellular carcinoma (2008)
  • Author(s): Ohki T, Goto T, Yoshida H 他11名
  • Journal Title: Clinical Gastroenterology and Hepatology 6 Pages: 459-464
  • Peer Reviewed
• [Journal Article] Risk assessment of hepatocellular carcinoma in chronic hepatitis C patients by transient elastography (2008)
  • Author(s): Masuzaki R, Yoshida H 他10名
  • Journal Title: Journal of Clinical Gastroenterology 42 Pages: 839-843
  • Peer Reviewed
• [Journal Article] 「NASH由来肝癌はわが国に存在するか」わが国のNASH関連肝癌発生率を推定する (2008)
  • Author(s): 吉田晴彦、五藤忠他7名
  • Journal Title: 日本消化器病学会雑誌 105 Pages: 1577-1583
  • Peer Reviewed
• [Journal Article] Serum level of adiponectin and the risk of liver cancer development.
  • Author(s): Arano T, Nakagawa H, Tateishi R, Ikeda H, Uchino K, Enooku K, Goto E, Masuzaki R, Asaoka Y, Kondo Y, Goto T, Shiina S, Omata M, Yoshida H, Koike K
  • Journal Title: Int J Cancer Epub
  • Peer Reviewed
• [Journal Article] Influence of serum HBV DNA load on recurrence of hepatocellular carcinoma after treatment with percutaneous radiofrequency ablation.
  • Author(s): Goto T, Yoshida H, Tateishi R, Enooku K, Goto E, Sato T, Ohki T, Masuzaki R, Imamura J, Shiina S, Koike K, Omata M
  • Journal Title: Hepatol Int
  • Peer Reviewed
• [Presentation] RISK FACTORS FOR HEPATOCARCINOGENESIS IN NON-VIRAL, NO N-ALCOHOLIC HEPATITIS AND CIRRHOSIS (2011)
  • Author(s): Enooku K, Yoshida H, 他12名
  • Organizer: EASL2011
  • Place of Presentation: ベルリン、ドイツ
  • Year and Date: 2011-04-01
• [Presentation] 脂肪肝の消失は発癌のリスクファクターである (2010)
  • Author(s): 榎奥健一郎、建石良介、新野徹、内野康志、後藤絵里子、中川隼人、増崎亮太、近藤祐嗣、五藤忠、椎名秀一朗、吉田晴彦、小池和彦
  • Organizer: JDDW2010
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] Visceral fat accumulation is an independent risk factor of hepatocellular carcinoma recurrence after curative treatment in NASH suspected patients. (2008)
  • Author(s): Ohki T, Goto T, Yoshida H他
  • Organizer: AASLD 2008
  • Place of Presentation: Los Angeles
  • Year and Date: 2008-11-03
• [Presentation] Visceral fat accumulation is an independent risk factor f hepatcellular carcinoma recurrence after curative treatment in NASH suspected patients. (2008)
  • Author(s): 大木隆正, 建石良介, 椎名秀一朗, 後藤絵里子, 佐藤隆久, 増崎亮太, 五藤忠, 浜村啓介, 金井文彦, 吉田英雄, 川辺隆夫, 小俣政男
  • Organizer: 59th AASLD Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2008-10-31
• [Presentation] HBc抗体陽性はC型慢性肝炎患者の肝発癌に影響を与えない (2008)
  • Author(s): 大木隆正、建石良介、後藤絵里子、佐藤隆久、増崎亮太、五藤忠、浜村啓介、吉田英雄、金井文彦、加藤直也、椎名秀一朗、吉田晴彦、川辺隆夫、小俣政男
  • Organizer: 第44回日本肝臓学会総会
  • Place of Presentation: 松山
  • Year and Date: 2008-06-05
• [Presentation] NASHと肝細胞癌 非B非C肝癌の特徴と予後 (2008)
  • Author(s): 大木隆正、建石良介、後藤絵里子、佐藤隆久、増崎亮太、五藤忠、浜村啓介、吉田英雄、金井文彦、椎名秀一朗、吉田晴彦、川辺隆夫、小俣政男
  • Organizer: 第44回日本肝癌研究会
  • Place of Presentation: 大阪
  • Year and Date: 2008-05-22
• [Book] 肝胆膵エキズパートマニュアル (2008)
  • Author(s): 小俣政男、伊佐山浩通、吉田晴彦、椎名秀一朗
  • Total Pages: 441
  • Publisher: 羊土社