Study of Mitochondria dysfunction mechanism caused by HCV infection.

• Project/Area Number: 20590764
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: MORIYA Kyoji The University of Tokyo, 医学部附属病院, 教授 (00272550)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: HCV / ミトコンドリア / C型肝炎 / 肝臓学

Research Abstract

Liver mitochondria proteomics analysis revealed that HCV core protein directly altered amount of several mitochondria proteins. These proteins may be useful targets of not only new hepatitis C therapy but also of hepatocellular carcinogenesis prevention

Research Products

• [Journal Article] Liquid chromatographic separation of proteins derivatized with a fluorogenic reagent at cysteinyl residues on a non-porous column for differential proteomics analysis. (2011)
  • Author(s): Koshiyama A, Ichibangase T, Moriya K, Koike K, Yazawa I, Imai K.
  • Journal Title: J Chromatogr A. 1218(22) Pages: 3447-52
• [Journal Article] Reply to the Letter to the Editor 'Effect of treatment with polyunsatured fatty acids on HCV-or diet-induced fatty liver. (2011)
  • Author(s): Koike K, Miyoshi H, Yotsuyanagi H, Moriya K.
  • Journal Title: J Hepatol. 54(6) Pages: 1326-1326
• [Journal Article] Evaluation of multiplex PCR using dual-priming oligonucleotide for the detection of vanA and vanB in vancomycin-resistant enterococci. (2011)
  • Author(s): Nagai R, Saito R, Koyano S, Okamura N, Yokota H, Kitazawa T, Moriya K.
  • Journal Title: Clin Chem Lab Med. 49(4) Pages: 751-2
• [Journal Article] Pathogenesis of lipid metabolism disorder in hepatitis C : polyunsaturated fatty acids counteract lipid alterations induced by the core protein. (2011)
  • Author(s): Miyoshi H, Moriya K, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Fujinaga H, Goto K, Todoroki T, Suzuki T, Miyamura T, Matsuura Y, Yotsuyanagi H, Koike K.
  • Journal Title: J Hepatol. 54(3) Pages: 432-8
• [Journal Article] Effect of treatment with polynsatured fatty acids on Hcv-ordiet-induced fatty liver. (2011)
  • Author(s): Koike K, Miyoshi H, Yotsuyanagi H, Moriya K.
  • Journal Title: J Hepatol. Volume: 4 Pages: 704-706
  • Peer Reviewed
• [Journal Article] Lipid metabolism and liver disease in hepatitis C viral infection. (2010)
  • Author(s): Koike K, Tsutsumi T, Yotsuyanagi H, Moriya K.
  • Journal Title: Oncology. 1 Pages: 24-30
• [Journal Article] Animal models for hepatitis C and related liver disease. (2010)
  • Author(s): Koike K, Moriya K, Matsuura Y.
  • Journal Title: Hepatol Res. 40(1) Pages: 69-82
  • NAID: 10027406832
• [Journal Article] Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells. (2010)
  • Author(s): Moriya K, Miyoshi H, Shinzawa S, Tsutsumi T, Fujie H, Goto K, Shintani Y, Yotsuyanagi H, Koike K.
  • Journal Title: J Med Virol. Volume: 82(5) Pages: 776-792
  • Peer Reviewed
• [Journal Article] Lipid metabolism and liver disease in hepatitis C viral infection. (2010)
  • Author(s): Koike K, Tsutsumi T, Yotsuyanagi H, Moriya K.
  • Journal Title: Oncology. Volume: 78suppll Pages: 24-30
  • Peer Reviewed
• [Journal Article] Pathogenesis of lipid metabolism disorder in hepatitis C : polyunsaturated fatty acids counteract lipid alterations induced by the core protein. (2010)
  • Author(s): Miyoshi H, Moriya K, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Fujinaga H, Goto K, Todoroki T, Suzuki T, Miyamura T, Matsuura Y, Yotsuyanagi H, Koike K.
  • Journal Title: J Hepatol. Volume: 54(3) Pages: 432-438
  • Peer Reviewed
• [Journal Article] Evaluation of a chromogenic agar medium for the detection of extended-spectrum ss-lactamase-producing Enterobacteriaceae. (2010)
  • Author(s): Saito R, Koyano S, Nagai R, Okamura N, Moriya K, Koike
  • Journal Title: Left Appl Microbiol Volume: 51(6) Pages: 704-706
  • Peer Reviewed
• [Journal Article] Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells. (2010)
  • Author(s): Moriya K, Miyoshi H, Shinzawa S, Tsutsumi T, Fujie H, Goto K, Shintani Y, Yotsuyanagi H, Koike K.
  • Journal Title: J Med Virol. 82(5) Pages: 776-92
  • Peer Reviewed
• [Journal Article] Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein : analysis using mouse model and cultured cells. (2009)
  • Author(s): Moriya K, Miyoshi H, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Yotsuyanagi H, Moriishi K, Matsuura Y, Suzuki T, Miyamura T, Koike K.
  • Journal Title: Am J Pathol. 175(4) Pages: 1515-24
• [Journal Article] Tsutsumi T, Matsuda M, Aizaki H, Moriya K, Miyoshi H, Fujie H, Shintani Y, Yotsuyanagi H, Miyamura T, Suzuki T, Koike K. (2009)
  • Author(s): Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondria) protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein.
  • Journal Title: Hepatology. 50(2) Pages: 378-86
• [Journal Article] Analysis of plasmid-mediated multidrug resistance in Escherichia coli and Klebsiella oxytoca isolates from clinical specimens in Japan. (2009)
  • Author(s): Ode T, Saito R, Kumita W, Sato K, Okugawa S, Moriya K, Koike K, Okamura N.
  • Journal Title: Int J Antimicrob Agents. 34(4) Pages: 347-50
• [Journal Article] Yotsuyanagi H, Kikuchi Y, Tsukada K, Nishida K, Kato M, Sakai H, Takamatsu J, Hige S, Chayama K, Moriya K, Koike K. (2009)
  • Author(s): Chronic hepatitis C in patients co-infected with human immunodeficiency virus in Japan : a retrospective multicenter analysis.
  • Journal Title: Hepatol Res. 39(7) Pages: 657-63
• [Journal Article] Molecular characterizations of carbapenem and ciprofloxacin resistance in clinical isolates of Pseudomonas putida. (2009)
  • Author(s): Kumita W, Saito R, Sato K, Ode T, Moriya K, Koike K, Chida T, Okamura N.
  • Journal Title: J Infect Chemother. 15(1) Pages: 6-12
  • NAID: 10025128068
• [Journal Article] Ichibangase T, Moriya, Koike K, Imai K. (2009)
  • Author(s): Limitation of immunoaffinity column for the removal of abundant proteins froir plasma in quantitative plasma proteomics.
  • Journal Title: Biomed Chromatogr 23(5) Pages: 480-7
• [Journal Article] Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein: analysis using mouse model and cultured cells. (2009)
  • Author(s): Moriya K, Miyoshi H, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Yotsuyanagi H, Moriishi K, Matsuura Y, Suzuki T, Miyamura T, Koike K.
  • Journal Title: Am J Pathol. 175(4) Pages: 1515-24
  • Peer Reviewed
• [Journal Article] Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein. (2009)
  • Author(s): Tsutsumi T, Matsuda M, Aizaki H, Moriya K, Miyoshi H, Fujie H, Shintani Y, Yotsuyanagi H, Miyamura T, Suzuki T, Koike K.
  • Journal Title: Hepatology 50(2) Pages: 378-86
  • Peer Reviewed
• [Journal Article] Analysis of plasmid-mediated multidrug resistance in Escherichia coli and Klebsiella oxytoca isolates from clinical specimens in Japan. (2009)
  • Author(s): Ode T, Saito R, Kumita W, Sato K, Okugawa S, Moriya K, Koike K, Okamura N.
  • Journal Title: Int J Antimicrob Agents 34(4) Pages: 347-50
  • Peer Reviewed
• [Journal Article] Chronic hepatitis C in patients co-infected with human immunodeficiency virus in Japan : a retrospective multicenter analysis. (2009)
  • Author(s): Yotsuyanagi H, Kikuchi Y, Tsukada K, Nishida K, Kato M, Sakai H, Takamatsu J, Hige S, Chayama K, Moriya K, Koike K.
  • Journal Title: Hepatol Res 39(7) Pages: 657-63
  • NAID: 10025326580
  • Peer Reviewed
• [Journal Article] Limitation of immunoaffinity column for the removal of abundant proteins from plasma in quantitative plasma proteomics. (2009)
  • Author(s): Ichibangase T, Moriya K, Koike K, Imai K.
  • Journal Title: Biomed Chromatogr 23(5) Pages: 480-7
  • Peer Reviewed
• [Journal Article] Moleculer characterizations of carbapenem and ciprofloxacin resistance in clinical isolates of Pseudomonas putida (2009)
  • Author(s): Kumita W, Saito R, Sato K, Ode T, Moriya K, Koike K, Chida T, Okamura N
  • Journal Title: Infect Chemother Feb:15(1) Pages: 6-12
  • Peer Reviewed
• [Journal Article] Limitation of immunoaffinity column for the removal of Abundant proteins from plasma in quantitative plasma proteomics. (2009)
  • Author(s): Ichibangase T, Moriya K, Koike K, Imai K.
  • Journal Title: Biomed Chromatogr May;23(5) Pages: 480-487
  • Peer Reviewed
• [Journal Article] Acquisition of methicillin-resistant Staphylococcus aureus after living donor liver transplantation: a retro spective cohort study. (2009)
  • Author(s): Hashimoto M, Sugawara Y,Tamura S, Kaneko J,Matsui Y, Togashi J, Moriya K, Koike K, Makuuchi
  • Journal Title: BMC Infect Dis Nov11;8 Pages: 155-161
  • Peer Reviewed
• [Journal Article] Hashimoto M, Sugawara Y, Tamura S, Kaneko J, Matsui Y, Togashi J, Moriya K, Koike K, Makuuchi M. (2008)
  • Author(s): Acquisition of methicillin-resistant Staphylococcus aureus after living donor liver transplantation : a retrospective cohort study.
  • Journal Title: BMC Infect Dis. 8 Pages: 155-155
• [Journal Article] Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells.
  • Author(s): Moriya K, Miyoshi H, Shinzawa S, Tsutsumi T, Fujie H, Goto K, Shintani Y, Yotsuyanagi H, Koike K.
• [Presentation] HCV and hepatic steatosis (2010)
  • Author(s): Kyoji Moriya
  • Organizer: The JSH single topic conference. Tokyo Japan. 2010
  • Place of Presentation: Tokyo. Japan
  • Year and Date: 2010-11-18
• [Presentation] HCV and hepatic steatosis The JSH single topic conference (2010)
  • Author(s): Kyoji Moriya
  • Organizer: NASH2010
  • Place of Presentation: Tokyo Japan
  • Year and Date: 2010-11-08
• [Presentation] Clinical characteristics and prognostic factors in patients with Stenotrophomonas maltophilia bacteremia. (2010)
  • Author(s): Yoko Nukui Shuji Hatakeyama Kyoji Moriya, et al
  • Organizer: 14th International Congress on Infection Diseases
  • Place of Presentation: U.S.A Miami
  • Year and Date: 2010-03-09
• [Presentation] Decrease in patients acquiring metallo-bata-lactamase-producing Bacteria after introducing mandatory report system of carbapenem use, (2009)
  • Author(s): Takatoshi Kitazawa, Yoko Nukui, Yoshizumi Shintani, Kyoji Moriya
  • Organizer: East Asian Conference on infection control and prevention
  • Place of Presentation: 東京
  • Year and Date: 2009-11-12
• [Presentation] C型慢性肝炎における宿主因子と病態/治療 (2009)
  • Author(s): 四柳宏, 森屋恭爾, 山田典栄, 岡本賢, 小林稔, 松永光太郎, 高橋秀明, 後藤耕司, 三好秀征, 堤武也, 藤江肇, 新谷良澄, 奥瀬千晃, 安田清美, 鈴木通博, 小池和彦
  • Organizer: 日本肝臓学会大会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-14