| Project/Area Number |
20590765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
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| Research Institution | University of Toyama |
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Principal Investigator |
MINEMURA Masami University of Toyama, 大学病院, 講師 (10313602)
|
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHARA Terumi 富山大学, 大学院・医学薬学研究部(医学), 准教授 (60240777)
SUGUYAMA Toshiro 富山大学, 大学院・医学薬学研究部(医学), 教授 (00196768)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
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| Keywords | 超音波力学 / 多剤耐性遺伝子 / 肝癌 / 分子標的薬 |
|---|
| Research Abstract |
When the multidrug resistance gene is frequently induced during the chemotherapy of cancer, it is a significant obstacle to successful treatment. In the present study, it has been shown that combination with chemotherapeutic agents and ultrasound (US) causes a synergistic enhancement in killing multidrug-resistant cancer cells, including hepatoma cells. Although the mechanism of the enhanced cytotoxicity using US has not been fully clarified, the possibility exists that increased uptake of drugs is caused by US and enhanced sensitivity to US is related to increased membrane rigidity in the multidrug resistant phenotype.
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