Impact of gene silencing on the recurrence of hepatocellular carcinoma after living-donor liver transplantation
| Project/Area Number |
20590772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
NISHIMURA Takafumi (2009-2010) Kyoto University, 医学研究科, 特定講師 (40378732)
福田 善弘 (2008) Kyoto University, 医学研究科, 教授 (50127130)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA Yoshihiro 京都大学, 大学院・医学研究科, 教授 (50127130)
NISHIDA Naoshi 京都大学, 大学院・医学研究科, 助教 (60281755)
UEDA Mikiko 京都大学, 大学院・医学研究科, 講師 (20322159)
西村 貴文 京都大学, 医学研究科, 助教 (40378732)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 肝臓学 / 生物系 / 医歯薬学 / 内科系臨床医学 / 消化器内科学 / 肝細胞癌 / 生体肝移植 / 遺伝子メチル化 |
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| Research Abstract |
This study was conducted to elucidate whether epigenetic silencing of tumor suppressor genes in the tumor predict the recurrence of hepatocellular carcinoma after living-donor liver transplantation. Tumor and non-tumor tissues were obtained from 50 patients and promoter methylations of APC, CDKN2A, RASSF1A, HIC1, GSTP1, RUNX3, PRDM2, and SOCS1 were examined by combined bisulfite restriction analysis method (COBRA). Although higher levels of promoter methylation in tumor than non-tumor were noted, none of these were correlated to the recurrence of hepatocellular carcinoma.
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Report
(4 results)
Research Products
(25 results)
