Mechanisms of genetic alterations during the process of liver cancer development.
| Project/Area Number |
20590774
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
MARUSAWA Hiroyuki Kyoto University, 医学研究科, 講師 (80324630)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | AID / 肝癌 / 遺伝子変異 / APOBEC2 / 炎症 / p53 |
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| Research Abstract |
Tumorigenesis is a multistep process in which the accumulation of genetic alterations drives the transformation of normal cells into malignant derivatives. Activation-induced cytidine deaminase (AID) contributes to immune system diversity by inducing somatic hypermutations and class-switch recombinations of human immunoglobulin genes. The mutagenic activity of AID, however, can also induce genetic changes including somatic mutations and submicroscopic chromosomal deletions in various gene loci in hepatocytes and gastric epithelial cells and may lead to the development of cancer.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.2009
Author(s)
Takai A, Toyoshima T, Uemura M, Kitawaki Y, Marusawa H, Hiai H, Yamada S, Okazaki IM, Honjo T, Chiba T, Kinoshita K.
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Journal Title
Oncogene 28
Pages: 469-478
Related Report
Peer Reviewed
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