Role of adiponectin in the development of liver cancer
| Project/Area Number |
20590775
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
YOSHIDA Yuichi Osaka University, 医学系研究科, 助教 (30457014)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KISO Shinichi 大阪大学, 医学系研究科, 助教 (40335352)
WATABE Kenji 大阪大学, 医学系研究科, 助教 (50379244)
TSUTSUI Syusaku 大阪大学, 医学系研究科, 助教 (10359846)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
|
|---|
| Keywords | 肝発癌 / メタボリックシンドローム / アディポネクチン / 大腸癌 / ノックアウトマウス / 非アルコール性脂肪性肝疾患 / 癌化 / 細胞増殖 |
|---|
| Research Abstract |
Recently, the metabolic syndrome, a cluster of metabolic disorders often associated with visceral obesity, is reported to increase the risk of hepatocarcinogenesis. Although adiponectin is a plasma protein secreted from adipose tissue with known anti-diabetic and anti-atherogenic properties, its role in the development of liver cancer has remained unclear. In our current study, we investigated the growth of the transplanted liver tumors in the adiponectin knock out (KO) mice and demonstrated that KO mice showed the increased proliferation of liver tumors. These data indicated the possible anti-tumor role of adiponcetin in the development of liver cancer.
|
Report
(4 results)
Research Products
(54 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Adiponectin prevents progression of nonalcoholic steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization.2009
Author(s)
Fukushima J, Kamada Y, Matsumoto H, Yoshida Y, Ezaki H, Takemura T, Igura T, Tsutsui S, Kihara S, Funahashi T, Shimomura I, Tamura s, Kiso s, Hayashi N.
-
Journal Title
Related Report
Peer Reviewed
-
[Journal Article] Visceral obesity and hypoadiponectinemia are significant determinants of hepaticdysfunction. An epidemiological study of 3, 827 Japanese subjects.2009
Author(s)
Kamada Y, Nakamura T, Funahashi T, Ryo M, Nishizawa H, Okauchi Y, Fukushima J, Yoshida Y, Kiso s, Shimomura I, Hayashi N.
-
Journal Title
J Clin Gastroenterol (in press)
Related Report
Peer Reviewed
-
-
[Journal Article] Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice.2009
Author(s)
Ezaki H, Yoshida Y Saji Y, Takemura T, Fukushima J, Matsumoto H, Kamada Y, Wada A, lgura T, Kihara S, Funahashi T, Shimomura I, Tamura S, Kiso S, Hayashi N.
-
Journal Title
Biochem Biophys Res Commun. 378(1)(in press)
Pages: 68-72
Related Report
Peer Reviewed
-
-
[Presentation] Gab1 scaffolding adaptor protein is required for stem/progenitor cell mediated liver regeneration in mice.2010
Author(s)
Yoshida Y, Kizu T, Tsubakio M, Chatani N, Hamano M, Takemura T, Ezaki H, Kamada Y, Kiso S, Hayashi N.
Organizer
AASLD 2010 Boston, MA, USA, Hynes Convention Center
Place of Presentation
Parallel session(口頭発表)
Year and Date
2010-11-01
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 肝特異的HB-EGF欠損マウスを用いた急性肝障害時における肝再生の検討2008
Author(s)
竹村貴代, 吉田雄一, 木曽真一, 佐治雪子, 江崎久男, 福島寿一, 松本仁, 和田朗, 鎌田佳宏, 井倉技, 筒井秀作, 田村信司, 林紀夫
Organizer
第12回日本肝臓病学会大会
Place of Presentation
東京
Year and Date
2008-10-02
Related Report
-
-
-
-
[Presentation] Adipose tissue derived stromal cell (ADSC)を用いた肝再生療法開発に向けた検討2008
Author(s)
鎌田佳宏, 吉田雄一, 佐治雪子, 松本仁, 福島寿一, 江崎久男, 竹村貴代, 和田朗, 井倉技, 田村信司, 木曽真一, 林紀夫
Organizer
第94回日本消化器病学会総会
Place of Presentation
福岡
Year and Date
2008-05-10
Related Report
-
