| Project/Area Number |
20590775
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
YOSHIDA Yuichi Osaka University, 医学系研究科, 助教 (30457014)
|
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| Co-Investigator(Kenkyū-buntansha) |
KISO Shinichi 大阪大学, 医学系研究科, 助教 (40335352)
WATABE Kenji 大阪大学, 医学系研究科, 助教 (50379244)
TSUTSUI Syusaku 大阪大学, 医学系研究科, 助教 (10359846)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
|
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| Keywords | 肝発癌 / メタボリックシンドローム / アディポネクチン / 大腸癌 / ノックアウトマウス / 非アルコール性脂肪性肝疾患 / 癌化 / 細胞増殖 |
|---|
| Research Abstract |
Recently, the metabolic syndrome, a cluster of metabolic disorders often associated with visceral obesity, is reported to increase the risk of hepatocarcinogenesis. Although adiponectin is a plasma protein secreted from adipose tissue with known anti-diabetic and anti-atherogenic properties, its role in the development of liver cancer has remained unclear. In our current study, we investigated the growth of the transplanted liver tumors in the adiponectin knock out (KO) mice and demonstrated that KO mice showed the increased proliferation of liver tumors. These data indicated the possible anti-tumor role of adiponcetin in the development of liver cancer.
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