Mechanisms for hepatitis B virus replication and mutagenesis : investigations using virus-expressing mouse system.
| Project/Area Number |
20590776
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
OHKAWA Kazuyoshi Osaka University, 肝胆膵内科, 副部長 (80432540)
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| Co-Investigator(Kenkyū-buntansha) |
TATSUMI Tomohide 大阪大学, 大学院・医学系研究科・消化器内科学, 助教 (20397699)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肝臓学 / B型肝炎 / B型肝炎ウイルス複製 / B型肝炎ウイルス変異 / 無症候性HBVキャリア / 活動性B型肝炎発症 / HBV増殖活性 / インターフェロン-γ / 核酸アナログ / 薬剤耐性変異ウイルス / B型劇症肝疾患 |
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| Research Abstract |
We studied hepatitis B virus (HBV) replication and mutagenesis using in vitro and in vivo HBV-expressing systems. The findings showed that 1) HBV preS/S protein may not affect HBV replication in a single HBV-infected cell, that 2) interferon-γ may not play a role on the initial eradication of HBV, that 3) the novel type of HBV mutation associated with fulminant hepatic failure was identified, that 4) HBV mutations occurring from immunotolerant phase to immunoactive phase may reduce HBV replication, that 5) precore and preS2 mutations may support replication of lamivudine-resistant HBV, that 6) V1753 and C2189 mutations may result in the improved antiviral efficacy against adefovir, and that 7) the novel HBV mutation that confer resistance to multiple nucleos(t)ide analogs was identified.
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Report
(4 results)
Research Products
(29 results)
