Analysis of iron regulating factors in chronic hepatitis C

• Project/Area Number: 20590787
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Sapporo Medical University
• Principal Investigator: MIYANISHI Kouji Sapporo Medical University, 医学部, 講師 (60372819)
• Co-Investigator(Kenkyū-buntansha): KATO Junji 札幌医科大学, 医学部, 教授 (20244345)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 遺伝子 / ウィルス / 細胞組織 / 内科 / 臨床 / C型慢性肝炎 / 鉄過剰 / ウイルス

Research Abstract

Increased iron absorption from the gastrointestinal tract causes hepatic iron accumulation, resulting in hepatic oxidative damage. We found that hepcidin expression increases and it upregulates FP-1 expression in small intestine in patients with chronic hepatitis C.

Research Products

• [Journal Article] フェロポルチン (2010)
  • Author(s): 小船雅義, 井山諭, 迦藤淳二
  • Journal Title: 日医雑誌 139(2) Pages: 1338-1338
  • Peer Reviewed
• [Journal Article] C型慢性肝炎における肝細胞がん発生と鉄の関係 (2010)
  • Author(s): 加藤淳二, 宮西浩嗣
  • Journal Title: 日医雑誌 136(2) Pages: 307-310
  • Peer Reviewed
• [Presentation] C型慢性肝炎おける鉄代謝異常の発生機序と除鉄療法の肝発癌抑制効果の検討 (2010)
  • Author(s): 宮西浩嗣
  • Organizer: 日本肝臓学会大会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-14
• [Presentation] JDDW2010パネルディスカッション7-3C型慢性肝炎おける鉄代謝異常の発生機序と除鉄療法の肝発癌抑制効果の検討 (2010)
  • Author(s): 宮西浩嗣、加藤淳二
  • Place of Presentation: 東京
• [Presentation] 鉄とC型肝炎 (2009)
  • Author(s): 宮西 浩嗣
  • Organizer: 日本栄養病態学会
  • Place of Presentation: 京都
  • Year and Date: 2009-01-10
• [Remarks] ホームページ等