Significance of HBV integration in clonal proliferation of hepatocytes
Project/Area Number |
20590791
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
MINAMI Masahito Kyoto Prefectural University of Medicine, 医学研究科, 講師 (60326220)
|
Research Collaborator |
MIYAGAWA Masami 京都府立医科大学, 大学院生
SENDO Rei 京都府立医科大学, 大学院生
KATAYAMA Takayuki 京都府立医科大学, 大学院生
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | B型肝炎ウイルス / 肝発癌 / 組み込み / HBV |
Research Abstract |
Hepatitis B virus (HBV) DNA can be integrated into the host genome and co-exist after its replication become decreased. In this study we revealed that HBV integration does not occur randomly, but is preferentially located in the certain region of the host genome. In those regions, there are many human genes related to cell proliferation, suggesting that HBV integration plays some role in modulating cell cycle. This mechanism can be related to viral persistence in the host cells and resulting liver carcinogenesis.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease.2011
Author(s)
Park H, Shima T, Yamaguchi K, Mitsuyoshi H, Minami M, Yasui K, Itoh Y, Yoshikawa T, Fukui M, Hasegawa G, Nakamura N, Ohta M, Obayashi H, Okanoue T.
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Journal Title
J Gastroenterol 46(1)
Pages: 101-107
NAID
Related Report
Peer Reviewed
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[Journal Article] PEG10 is a probable target for the amplification at 7q21 detected in hepatocellular carcinoma.2010
Author(s)
Tsuji K, Yasui K, Gen Y, Endo M, Dohi O, Zen K, Mitsuyoshi H, Minami M, Itoh Y, Taniwaki M, Tanaka S, Arii S, Okanoue T, Yoshikawa T.
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Journal Title
Cancer Genet Cytogenet 198
Pages: 118-125
Related Report
Peer Reviewed
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[Journal Article] Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease.2010
Author(s)
Park H, Ishigami A, Shima T, Mizuno M, Maruyama N, Yamaguchi K, Mitsuyoshi H, Minami M, Yasui K, Itoh Y, Yoshikawa T, Fukui M, Hasegawa G, Nakamura N, Ohta M, Obayashi H, Okanoue T.
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Journal Title
J Gastroenterol 45(4)
Pages: 426-434
NAID
Related Report
Peer Reviewed
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[Journal Article] Steatosis and hepatic expression of genes regulating lipid metabolism in Japanese patients infected with hepatitis C virus.2010
Author(s)
Yasui K, Harano Y, Mitsuyoshi H, Tsuji K, Endo M, Nakajima T, Minami M, Itoh Y, Zen Y, Nakanuma Y, Yoshikawa T, Okanoue T.
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Journal Title
J Gastroenterol 45(1)
Pages: 95-104
NAID
Related Report
Peer Reviewed
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[Journal Article] Relapse of hepatitis C in a pegylated-interferon-alpha-2b plus ribavirin-treated sustained virological responder.2010
Author(s)
Fujii H, Itoh Y, Ohnishi N, Sakamoto M, Ohkawara T, Sawa Y, Nishida K, Nishimura T, Yamaguchi K, Yasui K, Minami M, Okanoue T, Ohkawara Y, Yoshikawa T.
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Journal Title
Hepatol Res 40(6)
Pages: 654-660
Related Report
Peer Reviewed
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[Journal Article] The fatty acid composition of plasma cholesteryl esters and estimated desaturase activities in patients with nonalcoholic fatty liver disease and the effect of long-term ezetimibe therapy on these levels.2010
Author(s)
Park H, Hasegawa G, Shima T, Fukui M, Nakamura N, Yamaguchi K, Mitsuyoshi H, Minami M, Yasui K, Itoh Y, Yoshikawa T, Kitawaki J, Ohta M, Obayashi H, Okanoue T.
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Journal Title
Clin Chim Acta 411(21-22)
Pages: 1735-1740
Related Report
Peer Reviewed
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[Journal Article] Lower circulating levels of dehydroepiandrosterone, independ- ent of insulin resistance, is an important determinant of severity of non-alcoholic steatohepatitis in Japanese patients.2010
Author(s)
Sumida Y, Yonei Y, Kanemasa K, Hara T, Inada Y, Sakai K, Imai S, Hibino S, Yamaguchi K, Mitsuyoshi H, Yasui K, Minami M, Itoh Y, Naito Y, Yoshikawa T, Okanoue T.
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Journal Title
Hepatol Res 40(9)
Pages: 901-910
Related Report
Peer Reviewed
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[Journal Article] PEG10 is a probable target for the amplification at 7q21 detected in hepatocellular carcinoma.2010
Author(s)
Tsuji K, Yasui K, Gen Y, Endo M, Dohi O, Zen K, Mitsuyoshi H, Minami M, Itoh Y, Taniwaki M, Tanaka S, Arii S, Okanoue T, Yoshikawa T.
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Journal Title
Cancer Genet Cytogenet
Volume: 198
Pages: 118-125
Related Report
Peer Reviewed
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[Journal Article] Infrequent amplification of JUN in hepatocellular carcinoma.2009
Author(s)
Endo M, Yasui K, Nakajima T, Gen Y, Tsuji K, Dohi O, Zen K, Mitsuyoshi H, Minami M, Itoh Y, Taniwaki M, Tanaka S, Arii S, Okanoue T, Yoshikawa T.
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Journal Title
Anticancer Res 29
Pages: 4894-4898
Related Report
Peer Reviewed
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[Journal Article] ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry.2009
Author(s)
Zen K, Yasui K, Nakajima T, Zen Y, Zen K, Gen Y, Mitsuyoshi H, Minami M, Mitsufuji S, Tanaka S, Itoh Y, Nakanuma Y, Taniwaki M, Arii S, Okanoue T, Yoshikawa T.
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Journal Title
Genes Chromosomes Cancer 48(2)
Pages: 109-120
Related Report
Peer Reviewed
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[Journal Article] Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C : a Japanese multi-center study.2009
Author(s)
Okanoue T, Itoh Y, Hashimoto H, Yasui K, Minami M, Takehara T, Tanaka E, Onji M, Toyota J, Chayama K, Yoshioka K, Izumi N, Akuta N, Kumada H.
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Journal Title
J Gastroenterol 44(9)
Pages: 952-963
NAID
Related Report
Peer Reviewed
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[Journal Article] Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C : a Japanese multi-center study.2009
Author(s)
Miyagawa M, Minami M, Fujii K, Sendo R, Mori K, Shimizu D, Nakajima T, Yasui K, Itoh Y, Taniwaki M, Okanoue T, Izumi N, Akuta N, Kumada H.
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Journal Title
J Gastroenterol 44(9)
Pages: 952-963
NAID
Related Report
Peer Reviewed
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[Journal Article] Infrequent amplification of JUN in hepatocellular carcinoma2009
Author(s)
Endo M, Yasui K, Nakajima T, Gen Y, Tsuji K, Dohi O, Zen K, Mitsuyoshi H, Minami M, Itoh Y, Taniwaki M, Tanaka S, Arii S, Okanoue T, Yoshikawa T.
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Journal Title
Anticancer Res 29
Pages: 4989-4994
Related Report
Peer Reviewed
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[Journal Article] Molecular characterization of a variant virus that caused de novo hepatitis B without elevation of hepatitis B surface antigen after chemotherapy with rituximab.2008
Author(s)
Miyagawa M, Minami M, Fujii K, Sendo R, Mori K, Shimizu D, Nakajima T, Yasui K, Itoh Y, Taniwaki M, Okanoue T, Yoshikawa T.
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Journal Title
J Med Virol 80
Pages: 2069-2078
Related Report
Peer Reviewed
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[Journal Article] CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon frequently detected in hepatocellular carcinoma.2008
Author(s)
Inagaki Y, Yasui K, Endo M, Nakajima T, Zen K, Tsuji K, Minami M, Tanaka S, Taniwaki M, Itoh Y, Arii S, Okanoue T.
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Journal Title
Cancer Genet Cytogenet 180(1)
Pages: 30-36
Related Report
Peer Reviewed
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[Journal Article] Activation of B-Myb by E2F1 in hepatocellular carcinoma.2008
Author(s)
Nakajima T, Yasui K, Zen K, Inagaki Y, Fujii H, Minami M, Tanaka S, Taniwaki M, Itoh Y, Arii S, Inazawa J, Okanoue T.
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Journal Title
Hepatol Res 38(9)
Pages: 886-895
NAID
Related Report
Peer Reviewed
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[Journal Article] A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells.2008
Author(s)
Gen Y, Yasui K, Zen K, Nakajima T, Tsuji K, Endo M, Mitsuyoshi H, Minami M, Itoh Y, Tanaka S, Taniwaki M, Arii S, Okanoue T, Yoshikawa T.
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Journal Title
Cancer Lett 275(1)
Pages: 27-34
Related Report
Peer Reviewed
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[Journal Article] Non-prescription supplement-induced hepatitis with hyperferritinemia and mutation (H63D) in the HFE gene.2008
Author(s)
Fujii H, Takagaki N, Yoh T, Morita A, Ohkawara T, Yamaguchi K, Minami M, Sawa Y, Okanoue T, Ohkawara Y, Itoh Y.
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Journal Title
Hepatol Res 38(3)
Pages: 319-323
NAID
Related Report
Peer Reviewed
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[Journal Article] Guidelines for the antiviral therapy of hepatitis C virus carriers with normal serum aminotransferase based on platelet counts.2008
Author(s)
Okanoue T, Itoh Y, Minami M, Hashimoto H, Yasui K, Yotsuyanagi H, Takehara T, Kumada T, Tanaka E, Nishiguchi S, Izumi N, Sata M, Onji M, Yamada G, Okita K, Kumada H.
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Journal Title
Hepatol Res 38(1)
Pages: 27-36
NAID
Related Report
Peer Reviewed
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[Journal Article] Molecular characterization of a variant virus that caused de novo hepatitis B without elevation of hepatitis Bsurface antigen after chemotherapy with rituximab.2008
Author(s)
Miyagawa M, Minami M, Fujii K, Sendo R, Mori K, Shimizu D, Nakajima T, Yasui K, Itoh Y, Taniwaki M, Okanoue T, Yoshikawa T.
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Journal Title
Journal of Medical Virology 80(12)
Pages: 2069-2078
Related Report
Peer Reviewed
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