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Involvement of peritoneal macrophages and reactive mesothelial cells in pathological status of cirrhotic ascites

Research Project

Project/Area Number 20590793
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionNara Medical University

Principal Investigator

YAMAZAKI Masaharu  Nara Medical University, 医学部, 講師 (60360054)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Yasuyuki  奈良県立医科大学, 医学部, 教授 (70145879)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords肝硬変 / 腹水 / 腹膜中皮細胞 / 炎症性サイトカイン / VEGF / 酸化窒素 / フローサイトメトリー / 腹腔マクロファージ / 中皮細胞
Research Abstract

In this study, we found that high VEGF-A concentration was observed in the medium in a co-culture of peritoneal macrophages and reactive mesothelial cells, which are major cellular components in ascites of cirrhotic patients. Moreover it was revealed that the ratio of peritoneal macrophages and reactive mesothelial cells could influence inflammatory cytokines profile in the culture medium.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (8 results)

  • [Journal Article] Rapid Detection of Spontaneous Bacterial Peritonitis by Granulocyte Elastase Latex Immunoassay and Reagent Strip.2011

    • Author(s)
      Yamazaki M, Okamoto Y, et al (他6名)
    • Journal Title

      臨床病理 in press

    • NAID

      10029427504

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 劇症肝炎,亜急性肝炎,肝不全,肝性昏睡,肝不全【肝・胆道系症候群(第2版)その他の肝・胆道系疾患を含めて 肝臓編(上)】2010

    • Author(s)
      植村正人, 山崎正晴, 福井博
    • Journal Title

      日本臨床 別冊肝・胆道系症候群I

      Pages: 302-311

    • Related Report
      2010 Final Research Report
  • [Journal Article] 劇症肝炎、亜急性肝炎、肝不全、肝性昏睡 肝不全【肝・胆道系症候群(第2版) その他の肝・胆道系疾患を含めて 肝臓編(上)】2010

    • Author(s)
      植村正人, 山崎正晴, 福井博
    • Journal Title

      日本臨床(0047-1852)別冊肝・胆道系症候群I

      Pages: 302-311

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Determination of advanced glycation end-products on IgG in liver cirrhosis.2009

    • Author(s)
      Tanaka S, Yamazaki M, Okamoto Y.
    • Journal Title

      Hepatogastroenterology. 56

      Pages: 1735-1737

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of advanced glycation end-products on IgG in liver cirrhosis2009

    • Author(s)
      Tanaka S
    • Journal Title

      Hepatogastroenterology 56

      Pages: 1735-1737

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 消化器がん骨転移症例の臨床2010

    • Author(s)
      山崎正晴
    • Organizer
      第52回日本消化器病学会大会(JDDW 2010)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 進行した門脈腫瘍塞栓合併肝細胞癌症例における腹水の病態と治療2009

    • Author(s)
      山崎正晴
    • Organizer
      第38回日本肝臓学会西部会
    • Place of Presentation
      米子コンベンションセンター
    • Year and Date
      2009-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 進行した門脈腫瘍塞栓合併肝細胞癌症例における腹水の病態と治療2009

    • Author(s)
      山崎正晴
    • Organizer
      第38回 日本肝臓学会西部会
    • Place of Presentation
      米子コンベンションセンター
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腹水顆粒球エラスターゼと肝硬変腹水病態2009

    • Author(s)
      山崎正晴
    • Organizer
      第13回日本肝臓学会大会(JDDW 2009)
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-15
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 肝硬変腹水におけるアディポネクチンの検討2009

    • Author(s)
      山崎正晴
    • Organizer
      第56回日本臨床検査医学会学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2009-08-28
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 特発性細菌性腹膜炎が疑われた肝硬変腹水における腹水顆粒球エラスターゼの検討2008

    • Author(s)
      山崎正晴
    • Organizer
      第55回日本臨床検査医学会学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-11-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 非代償性肝硬変腹水におけるアディポネクチンの検討2008

    • Author(s)
      山崎正晴
    • Organizer
      第12回日本肝臓学会大会
    • Place of Presentation
      グランドプリンスホテル高輪、東京
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 顆粒球エラスターゼ定性試験紙を用いた特発性細菌性腹膜炎の迅速診断2008

    • Author(s)
      山崎正晴
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      愛媛県県民文化会館
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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