Involvement of peritoneal macrophages and reactive mesothelial cells in pathological status of cirrhotic ascites
| Project/Area Number |
20590793
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nara Medical University |
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Principal Investigator |
YAMAZAKI Masaharu Nara Medical University, 医学部, 講師 (60360054)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Yasuyuki 奈良県立医科大学, 医学部, 教授 (70145879)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 肝硬変 / 腹水 / 腹膜中皮細胞 / 炎症性サイトカイン / VEGF / 酸化窒素 / フローサイトメトリー / 腹腔マクロファージ / 中皮細胞 |
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| Research Abstract |
In this study, we found that high VEGF-A concentration was observed in the medium in a co-culture of peritoneal macrophages and reactive mesothelial cells, which are major cellular components in ascites of cirrhotic patients. Moreover it was revealed that the ratio of peritoneal macrophages and reactive mesothelial cells could influence inflammatory cytokines profile in the culture medium.
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Report
(4 results)
Research Products
(13 results)
