Role of autophagy in liver diseases
| Project/Area Number |
20590797
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Juntendo University |
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Principal Investigator |
YAMASHINA Shunhei Juntendo University, 医学部, 准教授 (30338412)
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| Co-Investigator(Kenkyū-buntansha) |
UENO Takashi 順天堂大学, 医学部, 先任准教授 (10053373)
IKEJIMA Kenichi 順天堂大学, 医学部, 准教授 (20317382)
TAKASHIMA Motoki 順天堂大学, 医学部, 非常勤助教
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | オートファジー / 肝障害 / 肝再生 / 細胞死 / 炎症 / 薬物性肝障害 / アポトーシス / ネクローシス / ROS / TNFα / 血管新生 |
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| Research Abstract |
We found that autophagy-deficiency enhances liver injury after ischemia-reperfusion or acetaminophen treatment, moreover, loss of autophagy blunts regeneration of the liver after partial hepatectomy. These findings indicate that autophagy plays a pivotal role on maintaining liver homeostasis in various liver diseases.
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Report
(4 results)
Research Products
(12 results)
