Mechanisms of Mallory body formation and elimination in hepatocytes
| Project/Area Number |
20590798
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
HARADA Masaru University of Occupational and Environmental Health, Japan, 医学部, 教授 (00241175)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 肝臓学 / Mallory-Denk体 / プロテアソーム / 小胞体ストレス / 酸化ストレス / オートファジー / ウイルス性肝炎 / ケラチン / 細胞内凝集体 / 蛋白分解 |
|---|
| Research Abstract |
Formation of Mallory-Denk bodies (MDB) was associated with abnormality of the intracellualr protein degradation system. Both proteasome and autophgy were associated with MDB formation. Endoplasmic reticulum stress and oxidative stress were related with MDB formation. MDB formation may be an adaptive response to these stresses. Modulation of autophagy was one of the therapeutic strategies of inclusion body-associated diseases including various liver diseases.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Late diagnosed Wilson disease with hepatic and neurological manifestations.2011
Author(s)
Honma Y, Harada M, Sato M, Katsuki Y, Hiura M, Shibata M, Narita R, Harada R, Abe S, Tabaru A, Tajiri N, Simajiri S
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Journal Title
Hepatol Res 41
Pages: 270-276
Related Report
Peer Reviewed
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[Journal Article] Copper incorporation into ceruloplasmin is regulated by Niemann-Pick C1 protein.
Author(s)
Yanagimoto C, Harada M, Kumemura H, Abe M, Koga H, Sakata M, Kawaguchi T, Terada K, Hanada S, Taniguchi E, Ninomiya H, Ueno T, Sugiyama T, Sata M
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Journal Title
NAID
Related Report
Peer Reviewed
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