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Fundamental study for development of a peptide vaccine against hepatitis C virus

Research Project

Project/Area Number 20590799
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKurume University

Principal Investigator

YAMADA Akira  Kurume University, 先端癌治療研究センター, 教授 (50158177)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsウイルス / 感染症 / 免疫学
Research Abstract

Fundamental studies for development of therapeutic and prophylactic vaccines against hepatitis C and liver cancers.
(1) New immuno-potentiator (adjuvant) was developed and its safety and immune-potentiating activity have been demonstrated in both animal and human.
(2) Hepatitis C vaccine applicable for virtually 100% of HLA types of Japanese was developed and its safety and immunological effects have been demonstrated in human clinical trials.
(3) Decrease of virus RNA and normalization of liver function (ALT) were observed in clinical trials. Prophylactic effect of vaccination against carcinogenesis and recurrence of HCV-related liver cancers was also observed.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (73 results)

All 2011 2010 2009 2008 Other

All Journal Article (38 results) (of which Peer Reviewed: 18 results) Presentation (21 results) Remarks (7 results) Patent(Industrial Property Rights) (7 results)

  • [Journal Article] Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination.2011

    • Author(s)
      Noguchi M, Mine T, Komatsu N, Suekane S, Moriya F, Matsuoka K, Yutani S, Shichijo S, Yamada A, Toh U, Kawano K, Azuma K, Uemura H, Okuno K, Matsumoto K, Yanagimoto H, Yamanaka R, Oka M, Todo S, Sasada T, Itoh K.
    • Journal Title

      Cancer Biol Ther. 12;10(12)

      Pages: 1266-79

    • Related Report
      2010 Final Research Report
  • [Journal Article] A phase I study of personalized peptide vaccination using 14 kinds of vaccine in combination with low-dose estramustine in HLA-A24-positive patients with castration-resistant prostate cancer.2011

    • Author(s)
      Noguchi M, Uemura H, Naito N, Akaza H, Yamada A, Itoh K.
    • Journal Title

      Prostate 71(5)

      Pages: 470-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] Characteristics of severe adverse events after peptide vaccination for advanced cancer patients : analysis of 500 cases.2011

    • Author(s)
      Yoshida K, Noguchi M, Mine T, Komatsu N, Yutani S, Ueno T, Yanagimoto H, Kawano K, Itoh K, Yamada A.
    • Journal Title

      Oncol Report 25(1)

      Pages: 57-62

    • Related Report
      2010 Final Research Report
  • [Journal Article] Phase I trial of a personalized Peptide vaccine for patients positive for human leukocyte antigen--A24 with recurrent or progressive glioblastoma multiforme.2011

    • Author(s)
      Terasaki M, Shibui S, Narita Y, Fujimaki T, Aoki T, Kajiwara K, Sawamura Y, Kurisu K, Mineta T, Yamada A, Itoh K.
    • Journal Title

      J Clin Oncol. 20;29(3)

      Pages: 337-44

    • Related Report
      2010 Final Research Report
  • [Journal Article] Phase-I clinical study of a personalized peptide vaccination available for six different HLA (HLA-A2, -A3, -A11, -A24, -A31, and -A33)-positive patients with advanced cancer.2011

    • Author(s)
      Yamada A, Noguchi M, Komatsu N, Suekane S, Yutani S, Moriya F, Mine T, Momozono K, Kawano K, Itoh K.
    • Journal Title

      Exp Ther Med. 2

      Pages: 109-117

    • Related Report
      2010 Final Research Report
  • [Journal Article] Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination.2011

    • Author(s)
      Noguchi M, Mine T, Komatsu N, Suekane S, Moriya F, Matsuoka K, Yutani S, Shichijo S, Yamada A, Toh U, Kawano K, Azuma K, Uemura H, Okuno K, Matsumoto K, Yanagimoto H, Yamanaka R, Oka M, Todo S, Sasada T, Itoh K.
    • Journal Title

      Cancer Biol Ther.

      Volume: 10(12) Pages: 1266-1279

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of personalized peptide vaccination using 14 kinds of vaccine in combination with low-dose estramustine in HLA-A24-positive patients with castration-resistant prostate cancer.2011

    • Author(s)
      Noguchi M, Uemura H, Naito N, Akaza H, Yamada A, Itoh K.
    • Journal Title

      Prostate.

      Volume: 71(5) Pages: 470-479

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of severe adverse events after peptide vaccination for advanced cancer patients : analysis of 500 cases.2011

    • Author(s)
      Yoshida K, Noguchi M, Mine T, Komatsu N, Yutani S, Ueno T, Yanagimoto H, Kawano K, Itoh K, Yamada A.
    • Journal Title

      Oncol Report

      Volume: 25(1) Pages: 57-62

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I trial of a personalized Peptide vaccine for patients positive for human leukocyte antigen--A24 with recurrent or progressive glioblastoma multiforme.2011

    • Author(s)
      Terasaki M, Shibui S, Narita Y, Fujimaki T, Aoki T, Kajiwara K, Sawamura Y, Kurisu K, Mineta T, Yamada A, Itoh K
    • Journal Title

      J Clin Oncol.

      Volume: 29(3) Pages: 337-344

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase-I clinical study of a personalized peptide vaccination available for six different HLA (HLA-A2, -A3, -All, -A24, -A31, and-A33)-positive patients with advanced cancer.2011

    • Author(s)
      Yamada A, Noguchi M, Komatsu N, Suekane S, Yutani S, Moriya F, Mine T, Momozono K, Kawano K, Itoh K.
    • Journal Title

      Exp Ther Med.

      Volume: 2 Pages: 109-117

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomized phase II trial of personalized peptide vaccine plus low dose estramustine (EMP) versus standard dose EMP in patients with hormone refractory prostate cancer.2010

    • Author(s)
      Noguchi M, Kakuma T, Uemura H, Nasu Y, Kumon H, Moriya F, Suekane S, Komatsu N, Yamada A, Itoh K.
    • Journal Title

      Cancer Immunol.Immunother. 59(7)

      Pages: 1001-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] Evaluation of a new oil adjuvant for use in peptide-based cancer vaccination.2010

    • Author(s)
      Iseki K, Matsunaga H, Komatsu N, Suekane S, Noguchi M, Itoh K, Yamada A.
    • Journal Title

      Cancer Sci. 101(10)

      Pages: 2110-4

    • NAID

      10027832060

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prophylactic effect of peptide vaccination against hepatocellular carcinoma associated with hepatitis Cvirus.2010

    • Author(s)
      Komatsu N, Yutani S, Yamada A, Shichijo S, Yoshida K, Itou M, Kuromatsu R, Ide T, Tanaka M, Sata M, Itoh K.
    • Journal Title

      Exp Ther Med. 1(4)

      Pages: 619-626

    • Related Report
      2010 Final Research Report
  • [Journal Article] Overcoming the hurdles of randomised clinical trials of therapeutic cancer vaccines.2010

    • Author(s)
      Sasada T, Komatsu N, Suekane S, Yamada A, Noguchi M, Itoh K.
    • Journal Title

      Eur J Cancer. 46(9)

      Pages: 1514-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] A phase II study of personalized peptide vaccination combined with gemcitabine for non-resectable pancreatic cancer patients.2010

    • Author(s)
      Yanagimoto H, Shiomi H, Satoi S, Mine T, Toyokawa H, Yamamoto T, Tani T, Yamada A, Kwon A, Komatsu N, Itoh K, Noguchi M.
    • Journal Title

      Oncol Rep. 24(3)

      Pages: 795-801

    • Related Report
      2010 Final Research Report
  • [Journal Article] A phase I study of personalized peptide vaccination for advanced urothelial carcinoma patients who failed treatment with methotrexate, vinblastine, adriamycin and cisplatin.2010

    • Author(s)
      Matsumoto K, Noguchi M, Satoh T, Tabata KI, Fujita T, Iwamura M, Yamada A, Komatsu N, Baba S, Itoh K.
    • Journal Title

      BJU Int. 16

    • Related Report
      2010 Final Research Report
  • [Journal Article] A randomized phase II trial of personalized peptide vaccine plus low dose estramustine (EMP) versus standard dose EMP in patients with hormone refractory prostate cancer.2010

    • Author(s)
      Noguchi M, Kakuma T, Uemura H, Nasu Y, Kumon H, Moriya F, Suekane S, Komatsu N, Yamada A, Itoh K.
    • Journal Title

      Cancer Immunol.Immunother.

      Volume: 59(7) Pages: 1001-1009

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a new oil adjuvant for use in peptide-based cancer vaccination.2010

    • Author(s)
      Iseki K, Matsunaga H, Komatsu N, Suekane S, Noguchi M, Itoh K, Yamada A.
    • Journal Title

      Cancer Sci.

      Volume: 101(10) Pages: 2110-2114

    • NAID

      10027832060

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overcoming the hurdles of randomised clinical trials of therapeutic cancer vaccines.2010

    • Author(s)
      Sasada T, Komatsu N, Suekane S, Yamada A, Noguchi M, Itoh K.
    • Journal Title

      Eur J Cancer.

      Volume: 46(9) Pages: 1514-1519

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase II study of personalized peptide vaccination combined with gemcitabine for non-resectable pancreatic cancer patients.2010

    • Author(s)
      Yanagimoto H, Shiomi H, Satoi S, Mine T, Toyokawa H, Yamamoto T, Tani T, Yamada A, Kwon A, Komatsu N, Itoh K, Noguchi M.
    • Journal Title

      Oncol Rep.

      Volume: 24(3) Pages: 795-801

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of personalized peptide vaccination for advanced urothelial carcinoma patients who failed treatment with methotrexate, vinblastine, adriamycin and cisplatin.2010

    • Author(s)
      Matsumoto K, Noguchi M, Satoh T, Tabata KI, Fujita T, Iwamura M, Yamada A, Komatsu N, Baba S, Itoh K.
    • Journal Title

      BJU Int.

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunological evaluation of personalized peptide vaccination in combination with UFT and UZEL for metastatic colorectal carcinoma patients2010

    • Author(s)
      Hattori T, Mine T, Komatu N, Yamada A, Itoh K, Shiozaki H, Okuno K.
    • Journal Title

      Cancer Immunol.Immunother. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomized phase II trial of personalized peptide vaccine pluslow dose estramustine(EMP)versus standard dose EMP in patients with hormone refractory prostate cancer2010

    • Author(s)
      Noguchi M, Kakuma T, Uemura H, Nasu Y, Kumon H, Moriya F, Suekane S, Komatsu N, Yamada A, Itoh K.
    • Journal Title

      Cancer Immunol.Immunother. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunological evaluation of personalized peptide vaccination in combination with UFT and UZEL for metastatic colorectal carcinoma patients.2009

    • Author(s)
      Hattori T, Mine T, Komatu N, Yamada A, Itoh K, Shiozaki H, Okuno K.
    • Journal Title

      Cancer Immunol.Immunother. 58(11)

      Pages: 1843-52

    • Related Report
      2010 Final Research Report
  • [Journal Article] A peptide derived from hepatitis C virus (HCV) core protein inducing cellular responses in patients infected with HCV with various HLA class IA allele.2009

    • Author(s)
      Niu Y, Komatsu N, Komohara Y, Matsueda S, Yutani S, Ishihara Y, Itou M, Yamada A, Itoh K, Shichijo S.
    • Journal Title

      J.Med.Virol. 81(7)

      Pages: 1232-40

    • Related Report
      2010 Final Research Report
  • [Journal Article] Phase I clinical study of a peptide vaccination for hepatitis C virus-infected patients with different HLA-class I-A alleles.2009

    • Author(s)
      Yutani S, Komatsu N, Shichijo S, Yoshida K, Takedatsu H, Itou M, Kuromatu R, Ide T, Tanaka M, Sata M, Yamada A, Itoh K.
    • Journal Title

      Cancer Science 100(10)

      Pages: 1935-42

    • Related Report
      2010 Final Research Report
  • [Journal Article] Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with carboplatin and paclitaxel.2009

    • Author(s)
      Azuma K, Sasada T, Kawahara A, Takamori S, Hattori S, Ikeda J, Itoh K, Yamada A, Kage M, Kuwano M, Aizawa H.
    • Journal Title

      Lung Cancer. 64(3)

      Pages: 326-33

    • Related Report
      2010 Final Research Report
  • [Journal Article] Recent advances in cancer vaccines : an overview.2009

    • Author(s)
      Itoh K, Yamada A, Mine T, Noguchi M.
    • Journal Title

      Jpn J Clin Oncol. 39(2)

      Pages: 73-80

    • Related Report
      2010 Final Research Report
  • [Journal Article] A peptide derived from hepatitis C virus(HCV)core protein inducing cellular responses in patients infected with HCV with various HLA class IA allele2009

    • Author(s)
      Niu Y, Komatsu N, Komohara Y, Matsueda S, Yutani S, Ishihara Y, Itou M, Yamada A, Itoh K, Shichijo S.
    • Journal Title

      J.Med.Virol. 81(7)

      Pages: 1232-1240

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I clinical study of a peptide vaccination for hepatitis C virus-infected patients with different HLA-class I-A alleles2009

    • Author(s)
      Yutani S, Komatsu N, Shichijo S, Yoshida K, Takedatsu H, Itou M, Kuromatu R, Ide T, Tanaka M, Sata M, Yamada A, Itoh K.
    • Journal Title

      Cancer Science 100(10)

      Pages: 1935-1942

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with carboplatin and paclitaxel2009

    • Author(s)
      Azuma K, Sasada T, Kawahara A, Takamori S, Hattori S, Ikeda J, Itoh K, Yamada A, Kage M, Kuwano M, Aizawa H.
    • Journal Title

      Lung Cancer. 64(3)

      Pages: 326-333

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A peptide derived from hepatitis C virus (HCV) core protein including cellular responses in patients infected with HCV with various HLA class IA alleles.2009

    • Author(s)
      Niu Y, Komatsu N, Komohara Y, Matsueda S, Yutani S, Is hihara Y, Itou M, Yamada A, Itoh K, Shichijo S.
    • Journal Title

      J. Med. Virol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arandomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms.2008

    • Author(s)
      Noguchi M, Kakuma T, Tomiyasu K, Yamada A, Itoh K, Konishi F, Kumamoto S, Shimizu K, Kondo R, Matsuoka K.
    • Journal Title

      Asian J.Androl. 10(5)

      Pages: 777-85

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification of EphB6 variant-derived epitope peptides recognized by cytotoxic T-lymphocytes from HLA-A24^+ malignant glioma patients.2008

    • Author(s)
      Jin M, Komohara Y, Shichijo S, Harada M, Yamanaka R, Miyamoto S, Nikawa J, Itoh K, Yamada A.
    • Journal Title

      Oncol.Report 19(5)

      Pages: 1277-83

    • Related Report
      2010 Final Research Report
  • [Journal Article] EphB6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in HLA-A2+ glioma patients.2008

    • Author(s)
      Jin M, Komohara Y, Shichijo S, Nikawa J, Yamanaka R, Itoh K, Yamada A.
    • Journal Title

      Cancer Sci. 99(8)

      Pages: 1656-62

    • Related Report
      2010 Final Research Report
  • [Journal Article] Dexamethasone did not suppress immune boosting by personalized peptide vaccination for advanced prostate cancer patients.2008

    • Author(s)
      Naito M, Itoh K, Komatsu N, Yamashita Y, Shirakusa T, Yamada A, Moriya F, Ayatuka H, Mohamed ER, Matsuoka K, Noguchi M.
    • Journal Title

      Prostate 68

      Pages: 1753-1762

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification of EphB6 variant-derived epitope peptides recognized by cytotoxic T-lymphocytes from HLA-A24^+ malignant glioma patients.2008

    • Author(s)
      Jin M, Komohara Y, Shichijo S, Harada M, Yamanaka R, Miyamoto S, Nikawa J, Itoh K, Yamada A.
    • Journal Title

      Oncol. Report 19(5)

      Pages: 1277-1283

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EphB6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in HLA-A2+ glioma patients.2008

    • Author(s)
      Jin M, Komohara Y, Shichijo S, Nikawa J, Yamanaka R, Itoh K, Yamada A.
    • Journal Title

      Cancer Scl. 99(8)

      Pages: 1656-1662

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] がんワクチン療法の現状と展望2011

    • Author(s)
      山田亮
    • Organizer
      第29回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      崇城大学市民ホール(熊本県)(招待講演)
    • Year and Date
      2011-01-27
    • Related Report
      2010 Final Research Report
  • [Presentation] がんワクチン療法の現状と展望2011

    • Author(s)
      山田亮
    • Organizer
      第29回日本言腔腫瘍学会総会・学術大会
    • Place of Presentation
      崇城大学市民ホール(熊本県)(招待講演)
    • Year and Date
      2011-01-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of peptide vaccine therapy for cancer2010

    • Author(s)
      山田亮、野口正典、伊東恭悟
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      RIHGA Royal Hotel Osaka(大阪府)
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] テーラーメイドペプチドワクチンの新たな展開2010

    • Author(s)
      山田亮、伊東恭悟
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      KKRホテル熊本(熊本県)
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 胆道がんに対するテーラーメイドペプチドワクチン治療2010

    • Author(s)
      吉富宗宏、由谷茂、吉山康一、峯孝志、山田亮、小松誠和、七條茂樹、伊東恭悟、木下壽文、野口正典
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      KKRホテル熊本(熊本県)
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 標準治療抵抗性肺がんに対するテーラーメイドペプチドワクチン療法第2相臨床試験2010

    • Author(s)
      吉山康一、高森信三、寺崎泰宏、山田亮、由谷茂、小松誠和、七條茂樹、伊東恭悟、野口正典、白水和雄
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      KKRホテル熊本(熊本県)
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 婦人科癌におけるテーラーメイドがんペプチドワクチン療法の第II相臨床試験(中間報告)2010

    • Author(s)
      河野光一郎、津田尚武、牛嶋公生、小松誠和、山田亮、伊東恭悟、嘉村敏治
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      KKRホテル熊本(熊本県)
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ドセタキセル抵抗性再燃前立腺がんに対するテーラーメイドペプチドワクチン第II相臨床試験2010

    • Author(s)
      守屋普久子、末金茂高、山田亮、小松誠和、笹田哲朗、七條茂樹、伊東恭悟、野口正典
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      KKRホテル熊本(熊本県)
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 膵臓癌におけるテーラーメイドペプチドワクチンとゲムシタビンの併用療法第II相臨床試験2009

    • Author(s)
      小松誠和、柳本泰明、山田亮、七條茂樹、伊東恭悟
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] ホルモン不応性再燃前立腺がんに対するテーラーメイドがんペプチドワクチン療法のランダム化比較試験2009

    • Author(s)
      山田亮、野口正典、小松誠和、伊東恭悟
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] がんワクチン開発の現状と展望2009

    • Author(s)
      山田亮
    • Organizer
      第16回薬と医療シンポジウム
    • Place of Presentation
      兵庫医療大学オクタホール(兵庫県)
    • Year and Date
      2009-08-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Immunological and clinical effects of personalized peptide vaccine for advanced cancer2009

    • Author(s)
      山田亮、野口正典、藤堂省、柳本泰明、山中龍也、岡正朗、松本和将、峯孝志、松岡啓、伊東恭悟
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2009-07-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 2年以上の長期テーラーメイド型ペプチドワクチン療法を行った進行再燃前立腺癌患者の免疫学的検討2009

    • Author(s)
      野口正典、末金茂高、守屋普久子、山田亮、伊東恭悟、松岡啓
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2009-07-03
    • Related Report
      2010 Final Research Report
  • [Presentation] テーラーメイドペプチドワクチン療法の現状と展望2009

    • Author(s)
      山田亮
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州(福岡県)
    • Year and Date
      2009-06-24
    • Related Report
      2010 Final Research Report
  • [Presentation] MVAC耐性進行・再発膀胱癌に対するテーラーメイド癌ペプチドワクチン療法の検討2009

    • Author(s)
      松本和将、佐藤威文、岩村正嗣、小松誠和、峯孝志、山田亮、伊東恭悟、馬場志郎
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州(福岡県)
    • Year and Date
      2009-06-24
    • Related Report
      2010 Final Research Report
  • [Presentation] テーラーメイドがんペプチドワクチン:実用化の展望2009

    • Author(s)
      山田亮、野口正典、由谷茂、伊東恭悟
    • Organizer
      第46回日本臨床分子医学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2009-04-12
    • Related Report
      2010 Final Research Report
  • [Presentation] C型肝炎ウイルス感染者に対する治療を目的としたペプチドワクチンの臨床試験2008

    • Author(s)
      山田亮、由谷茂、佐田通夫、伊東恭悟
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2008-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] テーラーメイド癌ペプチドワクチン臨床試験の生存解析:475症例でのアップデート2008

    • Author(s)
      峯孝志、野口正典、藤堂省、柳本泰明、植村天受、山中龍也、嘉村敏治、岡正朗、奥野清隆、松本和将、山田亮、伊東恭悟
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2008-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Clinical trial of therapeutic peptide vaccine of Hepatitis C virus infection.2008

    • Author(s)
      山田亮, 由谷茂, 佐田通夫, 伊東恭悟
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Determination of vaccine candidates for HLA-A26 positive patients with prostate cancer or HCV-related diseases.2008

    • Author(s)
      牛亜梅, 寺崎康展, 小松誠和, 野口正典, 七條茂樹, 山田亮, 伊東恭悟
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] HLA-A26前立腺癌患者およびHCV感染者に対するワクチン候補ペプチドの解析2008

    • Author(s)
      牛亜梅、寺崎康展、小松誠和、野口正典、七條茂樹、山田亮、伊東恭悟
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2008-10-29
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks] 久留米大学先端癌治療研究センター

    • URL

      http://www.med.kurume-u.ac.jp/med/sentanca/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks] 久留米大学免疫・免疫治療学講座

    • URL

      http://www.med.kurume-u.ac.jp/med/immun/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks] 久留米大学先端癌治療研究センター

    • URL

      http://www.med.kurume-u.ac.jp/med/sentanca/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks] 久留米大学免疫・免疫治療学講座

    • URL

      http://www.med.kurume-u.ac.jp/med/immun/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks] (久留米大学先端癌治療研究センター)

    • URL

      http://www.med.kurume-u.ac.jp/med/sentanca/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks] (久留米大学免疫・免疫治療学講座)

    • URL

      http://www.med.kurume-u.ac.jp/med/immun/index.html

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] C型肝炎ウイルスによる肝癌の発症および再発予防ワクチン2009

    • Inventor(s)
      伊東恭悟,佐田通夫,山田亮,由谷茂
    • Industrial Property Rights Holder
      久留米大学
    • Filing Date
      2009-10-27
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] C型肝炎ウイルス由来ペプチド2009

    • Inventor(s)
      山田亮、伊東恭悟、佐田通夫、由谷茂
    • Industrial Property Rights Holder
      (株)グリーンペプタイド
    • Acquisition Date
      2009-07-17
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] C型肝炎ウイルス由来ペプチド2009

    • Inventor(s)
      山田亮、伊東恭悟、佐田通夫、由谷茂
    • Industrial Property Rights Holder
      (株)グリーンペプタイド
    • Acquisition Date
      2009-07-17
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] C型肝炎ウイルス由来ペプチド2008

    • Inventor(s)
      山田亮、伊東恭悟、佐田通夫、由谷茂
    • Industrial Property Rights Holder
      (株)グリーンペプタイド
    • Filing Date
      2008-09-16
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] C型肝炎ウイルス由来ペプチド2008

    • Inventor(s)
      山田亮、伊東恭悟、佐田通夫、由谷茂
    • Industrial Property Rights Holder
      (株)グリーンペプタイド
    • Filing Date
      2008-12-15
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] C型肝炎ウイルスによる肝癌の発症および再発予防ワクチン2008

    • Inventor(s)
      伊東恭悟,佐田通夫,山田亮,由谷茂
    • Industrial Property Rights Holder
      久留米大学
    • Industrial Property Number
      2008-276163
    • Filing Date
      2008-10-27
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] C型肝炎ウイルスによる肝癌の発症および再発予防ワクチン2008

    • Inventor(s)
      伊東恭悟, 佐田通夫, 山田亮, 由谷茂
    • Industrial Property Rights Holder
      久留米大学
    • Industrial Property Number
      2008-276163
    • Filing Date
      2008-10-27
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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